Adult onset of ganglioneuroblastoma of the adrenal gland: case report and review of the literature

Bolzacchini, Elena; Martinelli, Barbara; Pinotti, Graziella

doi:10.1186/s40792-015-0062-0

Cited by 22 publications

(28 citation statements)

References 25 publications

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“…[ 8 ] Therefore, the patients should be followed closely (i.e., every 3 months for the first and second years, then every 6 months thereafter). Since high levels of catecholamine are related to recurrence, [ 2 ] Bolzacchini et al [ 18 ] suggested that blood count, urinary catecholamine analysis, and imaging should be performed at every examination. Scintigraphy with 131 iodine-methyliodobenzylguanidine, which can help to detect bone metastasis, is recommended to perform every 6 months, which can help detect bone metastasis, [ 7 , 19 ] .…”

Section: Discussionmentioning

confidence: 99%

Primary cervical ganglioneuroblastoma

et al. 2018

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Rationale:Ganglioneuroblastoma is usually located in the adrenal gland, retroperitoneal ganglia, or posterior mediastinum, but rarely occurs in the parapharyngeal space.Patient concerns:A 4-year-old girl presented with complaint of progressive inspiratory dyspnea and dysphagia, accompanying left-side Horner's syndrome.Diagnose:Computed tomography (CT) scan revealed a giant mass with irregular low density in left oropharyngeal and posterior pharyngeal wall. The left carotid artery sheath was pushed to the right. After enhancement, the central part of the mass was strengthened, and the surrounding bones structures appeard normal. Magnetic resonance imaging (MRI) showed a solid mass in the left parapharyngeal space displacing the left carotid sheath posteriorly and laterally. A ganglioneuroblastoma was diagnosed.Intervations:The girl was treated by surgery.Outcomes:The postoperative course was uneventful. There was no recurrence was observed during the 1-year follow-up.Lessons:The primary cervical ganglioneuroblastoma is rare, we recommended the ganglioneuroblastoma should be considered in the differential diagnosis of a child presenting with a parapharyngeal space mass.

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Section: Discussionmentioning

confidence: 99%

Primary cervical ganglioneuroblastoma

et al. 2018

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“…N-myc amplification was found to occur only in around 2% to 3.1% and 0% of 32 GNBLs and 10 GNs, respectively ( 41 , 52 ). In contrast, adult-onset NBLs and GNBLs are extremely rare, with fewer than 100 cases of these tumors having been reported in adults in the English medical literature to date ( 53 , 54 ). In comparison to pediatric cases, N-myc is less frequently amplified in adult-onset cases ( 53 ).…”

Section: Discussionmentioning

confidence: 99%

Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland

et al. 2016

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Composite pheochromocytoma (cPC) is extremely rare, arising in the adrenal medulla as a mixture of PC and other tumors of neural origin. We herein report on a case of adrenal incidentaloma post-operatively diagnosed as cPC with ganglioneuroblastoma (GNBL). The PC component had 7 points on the PASS, a Ki-67 index of 5.1%, a focal absence of sustentacular cells, and no genetic aberrations in succinate dehydrogenase subunit B. The GNBL component exhibited no N-myc amplification. Tumor cells of both components were stained positively for extracellular signal-regulated kinase 5 and ankyrin repeat domain 1. The aberrant activation of growth signaling may play a role in the marginal malignancy of cPC.

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“…GNBs frequently occur in children, but their onset in adults is extremely rare [ 4 ]. Adult GNBs have a high potential to be malignant, and there have been many reports of distant metastasis to various organs, including the liver and bones [ 5 ].…”

Section: Case Presentationmentioning

confidence: 99%

“…In our case, GNB developed in the adrenal gland. Including this case, there have been only 14 case reports in the English-language literature on GNB in adult adrenal glands [ 4 – 16 ], except for composite types with pheochromocytomas. Among these 14 cases, only four (including the present case) involved catecholamine-producing GNBs [ 6 – 8 ] (Table 2 ).…”

Section: Case Presentationmentioning

confidence: 99%

Surgical strategy for an adult patient with a catecholamine-producing ganglioneuroblastoma and a cerebral aneurysm: a case report

et al. 2018

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BackgroundGanglioneuroblastomas, particularly those that produce catecholamine, are extremely rare in adults. Here, we report an interesting surgical case of an adult patient with a catecholamine-producing ganglioneuroblastomas in her adrenal gland, suspected to be a pheochromocytoma, and with a cerebral aneurysm.Case presentationThe patient was a 73-year-old woman under treatment for hypertension. During a health check-up, a cystic retroperitoneal tumor was incidentally found in the superior pole of her right kidney. Her blood adrenaline level was slightly elevated, and her urinary adrenaline, noradrenaline, and dopamine levels were above the upper reference limits. In addition, 24-h urinary excretion of metanephrine, normetanephrine, and vanillylmandelic acid were all increased. 123I-Meta-iodobenzylguanidine scintigraphy showed an abnormal accumulation of the marker in the cyst wall. She was, therefore, diagnosed with a pheochromocytoma and scheduled for tumor resection. However, preoperatively, 8-mm-diameter cerebral aneurysm was incidentally found in her basilar artery. This required careful preoperative discussion. The aneurysm was difficult to approach and treat, and based on its position, shape, and size, the risk of rupture was low. Because hypertension is a major risk factor for aneurysmal rupture, we decided to proceed with the tumor resection. A lumbar catheter was placed to monitor the cerebral aneurysm for intraoperative rupture, and her transcranial motor-evoked potential and somatosensory-evoked potentials were monitored to track her intraoperative neurological function. During surgery, we carefully monitored fluctuations in blood pressure and resected the tumor with minimal mobilization. Postoperatively, head computed tomography confirmed that there was no sign of rupture. Histopathologically, the tumor was diagnosed as a catecholamine-producing ganglioneuroblastoma. The postoperative course was good, and the patient’s blood pressure improved.ConclusionsCareful perioperative management is needed for a patient with both a catecholamine-producing tumor and cerebral aneurysm.

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Adult onset of ganglioneuroblastoma of the adrenal gland: case report and review of the literature

Cited by 22 publications

References 25 publications

Primary cervical ganglioneuroblastoma

Primary cervical ganglioneuroblastoma

Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland

Surgical strategy for an adult patient with a catecholamine-producing ganglioneuroblastoma and a cerebral aneurysm: a case report

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