Adult-Onset Immunoglobulin A Vasculitis

Chadwick, Matthew; Shamban, Leonid; Macksood, John

doi:10.14309/crj.0000000000000306

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…GI manifestations are due to bowel ischemia and edema in the setting of vasculitis and can mimic the presentation of inflammatory bowel disease. These cases are also treated with IV steroids and cyclophosphamide, although severe cases with bowel perforation or infarction require surgical intervention [5,13]. Generally, adults affected by IgA vasculitis experience a more severe progression of the disease and often require more intense treatment approaches.…”

Section: Discussionmentioning

confidence: 99%

IgA Vasculitis Followed by IgA Nephropathy Without an Identifiable Trigger: The Same Disease or a Spectrum of Related Conditions?

Lapides,

Crespo-Quezada,

Thomas

et al. 2023

Cureus

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IgA vasculitis and IgA nephropathy are characterized by IgA deposition in blood vessels and glomerular mesangium, respectively. The former is far more common in the pediatric population, while the latter presents more often in adulthood. A consensus regarding whether these two conditions are manifestations of the same disease that occurs on a spectrum has not yet been reached, and, to our knowledge, no clinical trials to address this question have been conducted. Here, we describe a 27-year-old patient who presented to the emergency department multiple times before being diagnosed with IgA vasculitis with no identifiable trigger and soon after developed IgA nephropathy. This case highlights the importance of ruling out these conditions, especially IgA vasculitis, in adults presenting with a petechial rash, but also the need for studies that investigate whether and how these conditions are related so that patients can be appropriately diagnosed and treated as efficiently as possible.

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Section: Discussionmentioning

confidence: 99%

IgA Vasculitis Followed by IgA Nephropathy Without an Identifiable Trigger: The Same Disease or a Spectrum of Related Conditions?

Lapides,

Crespo-Quezada,

Thomas

et al. 2023

Cureus

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“…Intestinal wall edema and thickening cause intestinal obstruction and intussusception. It has been reported that the most commonly affected site is the small intestine, of which the descending duodenum is the most susceptible [9] . The study of Eon Jeong Nam et al stated that the terminal ileum is the most vulnerable, but this is based on adult reports [10] .…”

Section: Casementioning

confidence: 99%

IgA vasculitis with terminal ileitis and giant duodenum ulceration and review of the literatures

Wang

2021

Preprint

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BackgroundImmunoglobulin A vasculitis (IgA V), formerly Henoch–Schönlein purpura, is one of the most common self-limiting vasculitis in children. In 15-20% IgA V cases, gastrointestinal symptoms precede the rashes,they no specific gastrointestinal symptoms and often present as acute abdomen, making the diagnosis difficult.Case presentationWe present two female patients, ages 8 years old and 5 years old, who presented to vomiting and abdominal pain, rashes appeared on the lower limbs a few days later, they were subsequently diagnosed with IgA V. Both patients were given IV methylprednisolone, achieved benign clinical results.ConclusionsWhen gastrointestinal symptoms precede the rashes, it is difficult to diagnose IgA vasculitis, resulting in unnecessary surgery. Early recognition and treatment will promote the remission of the children and avoid unnecessary surgery.

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“…IgAV is uncommon in adults but more common in children, accounting for up to 45% of pediatric vasculitides. IgA vasculitis tends to progress more severely in adults, requiring more intensive treatment strategies [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Immunoglobulin A Vasculitis in an Adult Male

Shende,

Reddy,

Faruqi

et al. 2024

Cureus

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A 40-year-old Indian male presented with rash and abdominal pain, leading to a diagnosis of IgA vasculitis, a rare condition in adults. This systemic vasculitis involves IgA immune complex deposition, resulting in inflammation and tissue damage. Diagnosis relies on clinical features and biopsy findings, with management focused on symptom relief and addressing organ involvement. Long-term prognosis varies, emphasizing the importance of multidisciplinary care and patient education for optimal outcomes.

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Adult-Onset Immunoglobulin A Vasculitis

Cited by 3 publications

References 16 publications

IgA Vasculitis Followed by IgA Nephropathy Without an Identifiable Trigger: The Same Disease or a Spectrum of Related Conditions?

IgA Vasculitis Followed by IgA Nephropathy Without an Identifiable Trigger: The Same Disease or a Spectrum of Related Conditions?

IgA vasculitis with terminal ileitis and giant duodenum ulceration and review of the literatures

A Rare Case of Immunoglobulin A Vasculitis in an Adult Male

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