Adult-Onset Alexander Disease With Late-Presenting Vestibulopathy: A Case Report

Abstract

Alexander disease (AxD) is a progressive astrocytic leukodystrophy, primarily attributed to autosomal dominant or de novo mutations in the GFAP gene. 1 AxD presents differently across age groups, including infantile, juvenile, and adult subtypes, each with its own set of symptoms and prognoses. Adult-onset AxD accompanies bulbar symptoms, ataxia, autonomic dysfunction, and gait disturbance, while juvenile and infantile onset show cognitive