Adult neurogenesis in non‐mammalian vertebrates

Chapouton, Prisca; Jagasia, Ravi; Bally‐Cuif, Laure

doi:10.1002/bies.20615

Cited by 179 publications

(155 citation statements)

References 107 publications

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“…In the adult rodent dentate gyrus, astrocytes with a radial process bordering the subgranular zone (SGZ) serve as the NSCs (Seri et al, 2001(Seri et al, , 2004. Finally, throughout the brain of adult zebrafish Chapouton et al, 2006Chapouton et al, , 2007Grandel et al, 2006), some radial glial cells lining the ventricular zone (VZ) divide and can generate neurons Pellegrini et al, 2007;März et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Notch Activity Levels Control the Balance between Quiescence and Recruitment of Adult Neural Stem Cells

Chapouton¹,

Skupien

Hesl

et al. 2010

Journal of Neuroscience

241

269

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The limited generation of neurons during adulthood is controlled by a balance between quiescence and recruitment of neural stem cells (NSCs). We use here the germinal zone of the zebrafish adult telencephalon to examine how the frequency of NSC divisions is regulated. We show, using several in vivo techniques, that progenitors transit back and forth between the quiescent and dividing state, according to varying levels of Notch activity: Notch induction drives progenitors into quiescence, whereas blocking Notch massively reinitiates NSC division and subsequent commitment toward becoming neurons. Notch activation appears predominantly triggered by newly recruited progenitors onto their neighbors, suggesting an involvement of Notch in a self-limiting mechanism, once neurogenesis is started. These results identify for the first time a lateral inhibition-like mechanism in the context of adult neurogenesis and suggest that the equilibrium between quiescence and neurogenesis in the adult brain is controlled by fluctuations of Notch activity, thereby regulating the amount of adult-born neurons.

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Section: Introductionmentioning

confidence: 99%

Notch Activity Levels Control the Balance between Quiescence and Recruitment of Adult Neural Stem Cells

Chapouton¹,

Skupien

Hesl

et al. 2010

Journal of Neuroscience

241

269

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“…Zebrafish has recently emerged as an anamniote model in adult neural stem cell research due to its high proliferative and regenerative potential in the central nervous system (CNS) that exceeds by far mammalian capabilities (Zupanc, 2001(Zupanc, , 2006Adolf et al, 2006;Grandel et al, 2006;Chapouton et al, 2007). In the adult mammalian brain, two regions display neurogenic potential: The subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus located in the hippocampus harbour neural stem cells with astrocytic features generating predominantly neurons (Doetsch et al, 1999;Gage, 2000;Seri et al, 2001;Alvarez-Buylla and Garcia-Verdugo, 2002;Kempermann, 2002;Garcia et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Expression of the transcription factor Olig2 in proliferating cells in the adult zebrafish telencephalon

März

Schmidt

Rastegar

et al. 2010

Developmental Dynamics

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The telencephalon of the adult zebrafish is highly proliferative: Dividing cells are found along the entire ventricular zone and in the parenchyma. Here, we investigated the relation of proliferating cells in the telencephalic parenchyma to the oligodendrocyte lineage. We find at least three different cell types of the oligodendrocyte lineage (olig2-and sox10-positive) in the parenchyma of the telencephalon: Proliferating progenitors (PCNA-positive), including a subpopulation of slowly dividing progenitors (long term label-retaining), as well as mature oligodendrocytes (Mbp-positive) and presumptive quiescent OPCs (neither Mbppositive nor proliferating). Furthermore, in the ventricular zone (in and ventral to the RMS), two different subpopulations of olig2-positive cell populations are present. Since these ventricular olig2-positive cells do not express the oligodendrocyte marker sox10, it is not clear whether these cells indeed belong to the oligodendrocyte lineage. Taken together, we detected at least five different classes of olig2-positive cells in the telencephalon of the adult zebrafish. Developmental Dynamics 239:3336-3349,

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“…These two "canonical" sites of adult neurogenesis have been found in all animal species studied so far, including humans (reviewed in Lindsey and Tropepe 2006;Bonfanti and Ponti 2008;Kempermann 2012;Grandel and Brand 2013). Although in several classes of vertebrates including fish, amphibians, and reptiles, adult neurogenesis is widespread in many areas of the CNS (Zupanc 2006;Chapouton et al 2007;Grandel and Brand 2013), in mammals, the vast majority of the brain and spinal cord regions out of the germinal-layer-derived neurogenic sites are commonly referred to as "nonneurogenic parenchyma" (Sohur et al 2006;Bonfanti and Peretto 2011;Bonfanti and Nacher 2012). However, this viewpoint has changed during the last few years.…”

mentioning

confidence: 99%

Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain

Feliciano

Bordey

Bonfanti

2015

Cold Spring Harb Perspect Biol

106

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Two decades after the discovery that neural stem cells (NSCs) populate some regions of the mammalian central nervous system (CNS), deep knowledge has been accumulated on their capacity to generate new neurons in the adult brain. This constitutive adult neurogenesis occurs throughout life primarily within remnants of the embryonic germinal layers known as "neurogenic sites." Nevertheless, some processes of neurogliogenesis also occur in the CNS parenchyma commonly considered as "nonneurogenic." This "noncanonical" cell genesis has been the object of many claims, some of which turned out to be not true. Indeed, it is often an "incomplete" process as to its final outcome, heterogeneous by several measures, including regional location, progenitor identity, and fate of the progeny. These aspects also strictly depend on the animal species, suggesting that persistent neurogenic processes have uniquely adapted to the brain anatomy of different mammals. Whereas some examples of noncanonical neurogenesis are strictly parenchymal, others also show stem cell niche-like features and a strong link with the ventricular cavities. This work will review results obtained in a research field that expanded from classic neurogenesis studies involving a variety of areas of the CNS outside of the subventricular zone (SVZ) and subgranular zone (SGZ). It will be highlighted how knowledge concerning noncanonical neurogenic areas is still incomplete owing to its regional and species-specific heterogeneity, and to objective difficulties still hampering its full identification and characterization.

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Adult neurogenesis in non‐mammalian vertebrates

Cited by 179 publications

References 107 publications

Notch Activity Levels Control the Balance between Quiescence and Recruitment of Adult Neural Stem Cells

Notch Activity Levels Control the Balance between Quiescence and Recruitment of Adult Neural Stem Cells

Expression of the transcription factor Olig2 in proliferating cells in the adult zebrafish telencephalon

Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain

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