Adult neurogenesis in eight Megachiropteran species

Chawana, Richard; Patzke, Nina; Kaswera, Consolate; Gilissen, Emmanuel; Ihunwo, Amadi O.; Manger, Paul P.R.

doi:10.1016/j.neuroscience.2013.04.020

Cited by 26 publications

(41 citation statements)

References 48 publications

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“…Powers, 2013). It should be noted here that Amrein et al (2007) only studied species from the microchiropteran suborder of bats, and not the megachiropteran suborder, for which two recent reports have detailed the presence of adult hippocampal neurogenesis in a range of megachiropteran species (Gatome et al, 2010;Chawana et al, 2013), making the title and conclusions of the Amrein et al (2007) paper misleading as they use only the generic term bats.…”

Section: Discussionmentioning

confidence: 99%

“…Reports detailing the presence of adult hippocampal neurogenesis across mammalian species are becoming more numerous, and in each case, it would appear that adult hippocampal neurogenesis is present (reviewed in Kempermann, 2012; see also Patzke et al, 2013;Chawana et al, 2013). Thus, at this stage, with the presence of adult hippocampal neurogenesis in the microchiropterans, it would appear that this neural trait is a common feature of mammalian brains; however, as mentioned by Kempermann (2012), certain species, such as cetaceans that live in homogeneous environments, do need to be examined to determine whether there is phylogenetic variability in this trait.…”

Section: Discussionmentioning

confidence: 99%

“…Studies of adult neurogenesis in wild-living mammals are becoming more common due to the need to understand this process in relation to normal life-history parameters (Bartkowska et al 2010;Amrein et al, 2011;Kempermann, 2012;Patzke et al 2013;Chawana et al, 2013;Cavegn et al, 2013). The investigation of wild-living mammals may provide a broader understanding of the dynamics and mechanisms influencing adult neurogenesis for species in their natural habitat and ultimately reveal potential reasons for the presence of adult neurogenesis in the mammalian brain.…”

Section: Introductionmentioning

confidence: 99%

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Microbats appear to have adult hippocampal neurogenesis, but post-capture stress causes a rapid decline in the number of neurons expressing doublecortin

et al. 2014

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Highlights• Clear adult neurogenesis was observed in three species of microchiropterans.• Microchiropteran adult neurogenesis is similar to that of other mammals.• Capture stress causes a rapid decline in detectable hippocampal neurogenesis.• Adult hippocampal neurogenesis appears to be a common mammalian neural trait. Abstract:A previous study looking for evidence of adult hippocampal neurogenesis in microchiropteran bats failed to reveal the strong presence of this neural trait. As microchiropterans have a high metabolic rate and are small, it is possible that 2 capture/handling stress could have led to a decrease in the detectable presence of adult hippocampal neurgenesis. In this study we looked for adult hippocampal neurogenesis using immunohistochemical techniques for the endogenous marker doublecortin in 10 species of microchiropterans euthanized and perfusion fixed at specific time points following capture.Our result indicate that when euthanized and perfused within 15 minutes of capture, abundant adult hippocampal neurogenesis could be detected with doublecortin immunhistochemistry.Between 15 and 30 minutes post-capture, the detectable levels of doublecortin dropped dramatically, and after 30 minutes post-capture, immunohistochemistry for doublecortin could not reveal any significant adult hippocampal neurogenesis. Thus, as with all other mammals studied to date, bats, including both microchiropterans and megachiropterans, exhibit substantial levels of adult hippocampal neurogenesis. The present study underscores the concept that, as with laboratory studies, studies of wild-caught animals need to be cognizant of the fact that stress (capture/handling) can induce major changes in the appearance of specific neural traits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microbats appear to have adult hippocampal neurogenesis, but post-capture stress causes a rapid decline in the number of neurons expressing doublecortin

et al. 2014

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“…In contrast, in megachiropteran species, or fruiteating bats, all animals investigated so far show AHN, albeit at very low levels when compared with rodents. Robust but low numbers of proliferating cells and young neurons were found in wild Wahlberg's epauletted fruit bat (Epomophorus wahlbergi [Gatome et al 2010]) and in seven additional species of wild megachiropterans (Chawana et al 2013). In contrast to low or absent AHN in bats, high numbers of young cells of the neuronal lineage have been reported in the hippocampus of carnivores such as cats (Altman 1963), wild red foxes (Vulpes vulpes [Amrein and Slomianka 2010]), and several dog breeds (Hwang et al 2007;Siwak-Tapp et al 2007;De Nevi et al 2013).…”

Section: Evidence Of Hippocampal Neurogenesis In Other Wild and Domesmentioning

confidence: 99%

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Amrein

2015

Cold Spring Harb Perspect Biol

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This review will discuss adult hippocampal neurogenesis in wild mammals of different taxa and outline similarities with and differences from laboratory animals. It begins with a review of evidence for hippocampal neurogenesis in various mammals, and shows the similar patterns of age-dependent decline in cell proliferation in wild and domesticated mammals. In contrast, the pool of immature neurons that originate from proliferative activity varies between species, implying a selective advantage for mammals that can make use of a large number of these functionally special neurons. Furthermore, rapid adaptation of hippocampal neurogenesis to experimental challenges appears to be a characteristic of laboratory rodents. Wild mammals show species-specific, rather stable hippocampal neurogenesis, which appears related to demands that characterize the niche exploited by a species rather than to acute events in the life of its members. Studies that investigate adult neurogenesis in wild mammals are not numerous, but the findings of neurogenesis under natural conditions can provide new insights, and thereby also address the question to which cognitive demands neurogenesis may respond during selection.

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“…Neurons born in the wall of the third ventricle migrate to the hypothalamus and become leptin-responsive neurons [Kokoeva et al, 2005;Migaud et al, 2010;Cheng, 2013]. New neurons have also been documented in the adult striatum, amygdala, piriform cortex and neocortex, among other regions, although the conditions under which new neurons migrate to these less reported areas is debated [Bernier et al, 2002;Dayer et al, 2005;Luzzati et al, 2006Luzzati et al, , 2007Gould, 2007;Chawana et al, 2013;Ernst et al, 2014;Olaleye and Ihunwo, 2014;Inta et al, 2015;Saul et al, 2015].…”

Section: Direct Approaches To Understanding New Neuron Function: Renementioning

confidence: 99%

Adult Neurogenesis in the Songbird: Region-Specific Contributions of New Neurons to Behavioral Plasticity and Stability

Pytte

2016

Brain Behav Evol

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Our understanding of the role of new neurons in learning and encoding new information has been largely based on studies of new neurons in the mammalian dentate gyrus and olfactory bulb - brain regions that may be specialized for learning. Thus the role of new neurons in regions that serve other functions has yet to be fully explored. The song system provides a model for studying new neuron function in brain regions that contribute differently to song learning, song auditory discrimination, and song motor production. These regions subserve learning as well as long-term storage of previously learned information. This review examines the differences between learning-based and activity-based retention of new neurons and explores the potential contributions of new neurons to behavioral stability in the song motor production pathway.

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Adult neurogenesis in eight Megachiropteran species

Cited by 26 publications

References 48 publications

Microbats appear to have adult hippocampal neurogenesis, but post-capture stress causes a rapid decline in the number of neurons expressing doublecortin

Microbats appear to have adult hippocampal neurogenesis, but post-capture stress causes a rapid decline in the number of neurons expressing doublecortin

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Adult Neurogenesis in the Songbird: Region-Specific Contributions of New Neurons to Behavioral Plasticity and Stability

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