Adult Neurogenesis and Regeneration: Focus on Nonmammalian Vertebrates

Ferretti, Patrizia; Prasongchean, Weerapong

doi:10.1007/978-1-4939-1908-6_1

Cited by 3 publications

(1 citation statement)

References 116 publications

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“…Because of the varied functions of the mammalian hippocampus, there may be other, more dominating selective forces that select against a fixed phenotype, to cope with changes in the environment. Further, compared to mammals, squamate reptiles have higher levels of neurogenesis and a much greater ability to significantly remodel the brain after injury than do mammals [88,89]. The unique neural plasticity of this taxonomic group may further counter selection for a fixed cortical phenotype, as lack of plasticity may be maladaptive over the lifetime of the individual.…”

Section: (B) the Effects Of Intergenerational Stress On The Neural Ph...mentioning

confidence: 99%

The effects of early-life and intergenerational stress on the brain

LaDage,

McCormick,

Robbins

et al. 2023

Proc. R. Soc. B.

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Stress experienced during ontogeny can have profound effects on the adult phenotype. However, stress can also be experienced intergenerationally, where an offspring's phenotype can be moulded by stress experienced by the parents. Although early-life and intergenerational stress can alter anatomy, physiology, and behaviour, nothing is known about how these stress contexts interact to affect the neural phenotype. Here, we examined how early-life and intergenerational stress affect the brain in eastern fence lizards ( Sceloporus undulatus ). Some lizard populations co-occur with predatory fire ants, and stress from fire ant attacks exerts intergenerational physiological and behavioural changes in lizards. However, it is unclear if intergenerational stress, or the interaction between intergenerational and early-life stress, modulates the brain. To test this, we captured gravid females from fire ant invaded and uninvaded populations, and subjected offspring to three early-life stress treatments: (1) fire ant attack, (2) corticosterone, or (3) a control. Corticosterone and fire ant attack decreased some aspects of the neural phenotype while population of origin and the interaction of early-life stress and population had no effects on the brain. These results suggest that early-life stressors may better predict adult brain variation than intergenerational stress in this species.

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Section: (B) the Effects Of Intergenerational Stress On The Neural Ph...mentioning

confidence: 99%

The effects of early-life and intergenerational stress on the brain

LaDage,

McCormick,

Robbins

et al. 2023

Proc. R. Soc. B.

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Factors That Modulate Neurogenesis: A Top-Down Approach

LaDage

2016

Brain Behav Evol

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Although hippocampal neurogenesis in the adult brain has been conserved across the vertebrate lineage, laboratory studies have primarily examined this phenomenon in rodent models. This approach has been successful in elucidating important factors and mechanisms that can modulate rates of hippocampal neurogenesis, including hormones, environmental complexity, learning and memory, motor stimulation, and stress. However, recent studies have found that neurobiological research on neurogenesis in rodents may not easily translate to, or explain, neurogenesis patterns in nonrodent systems, particularly in species examined in the field. This review examines some of the evolutionary and ecological variables that may also modulate neurogenesis patterns. This ‘top-down' and more naturalistic approach, which incorporates ecology and natural history, particularly of nonmodel species, may allow for a more comprehensive understanding of the functional significance of neurogenesis.

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Broadening the functional and evolutionary understanding of postnatal neurogenesis using reptilian models

LaDage

2020

Journal of Experimental Biology

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The production of new neurons in the brains of adult animals was first identified by Altman and Das in 1965, but it was not until the late 20th century when methods for visualizing new neuron production improved that there was a dramatic increase in research on neurogenesis in the adult brain. We now know that adult neurogenesis is a ubiquitous process that occurs across a wide range of taxonomic groups. This process has largely been studied in mammals; however, there are notable differences between mammals and other taxonomic groups in how, why and where new neuron production occurs. This Review will begin by describing the processes of adult neurogenesis in reptiles and identifying the similarities and differences in these processes between reptiles and model rodent species. Further, this Review underscores the importance of appreciating how wild-caught animals vary in neurogenic properties compared with laboratory-reared animals and how this can be used to broaden the functional and evolutionary understanding of why and how new neurons are produced in the adult brain. Studying variation in neural processes across taxonomic groups provides an evolutionary context to adult neurogenesis while also advancing our overall understanding of neurogenesis and brain plasticity.

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Adult Neurogenesis and Regeneration: Focus on Nonmammalian Vertebrates

Cited by 3 publications

References 116 publications

The effects of early-life and intergenerational stress on the brain

The effects of early-life and intergenerational stress on the brain

Factors That Modulate Neurogenesis: A Top-Down Approach

Broadening the functional and evolutionary understanding of postnatal neurogenesis using reptilian models

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