Adult Meningism and Viral Meningitis, 1997-2004: Clinical Data and Cerebrospinal Fluid Cytokines

Nagafuchi, Masako; Nagafuchi, Yoshiro; Sato, Rumi; Imaizumi, T; Ayabe, Mitsuyoshi; Shoji, Hiroshi; Ichiyama, Takashi

doi:10.2169/internalmedicine.45.1769

Cited by 25 publications

(9 citation statements)

References 13 publications

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“…Rare but severe and sometimes fatal neurologic complications include meningitis or meningo-encephalitis [521–526], cerebellitis [527], and encephalitis [528, 529]. Other reports include posterior reversible encephalopathy syndrome [530], CLIPPERS syndrome [531], and fatal meningo-encephalomyelitis [532].…”

Section: Complicating Presentations and Disease Associationsmentioning

confidence: 99%

“…Other reports include posterior reversible encephalopathy syndrome [530], CLIPPERS syndrome [531], and fatal meningo-encephalomyelitis [532]. Again, those affected are generally immunocompromised [9, 10], although accruing evidence suggests that such complications affect young and/or immunocompetent individuals more often than was supposed [521, 533–538]. …”

Section: Complicating Presentations and Disease Associationsmentioning

confidence: 99%

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Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific

et al. 2017

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BackgroundHerpes zoster (HZ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens. Current treatments are not fully effective, especially among the most vulnerable patients. Although widely recommended, vaccination against HZ is not routine; barriers in Asia-Pacific include long-standing neglect of adult immunisation and sparse local data. To address knowledge gaps, raise awareness, and disseminate best practice, we reviewed recent data and guidelines on HZ from the Asia-Pacific region.MethodsWe searched PubMed, Scopus, and World Health Organization databases for articles about HZ published from 1994 to 2014 by authors from Australia, China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, New Zealand, the Philippines, Singapore, Taiwan, Thailand, and Vietnam. We selected articles about epidemiology, burden, complications, comorbidities, management, prevention, and recommendations/guidelines. Internet searches retrieved additional HZ immunisation guidelines.ResultsFrom 4007 retrieved articles, we screened-out 1501 duplicates and excluded 1264 extraneous articles, leaving 1242 unique articles. We found guidelines on adult immunisation from Australia, India, Indonesia, Malaysia, New Zealand, the Philippines, South Korea, and Thailand.HZ epidemiology in Asia-Pacific is similar to elsewhere; incidence rises with age and peaks at around 70 years – lifetime risk is approximately one-third. Average incidence of 3–10/1000 person-years is rising at around 5% per year. The principal risk factors are immunosenescence and immunosuppression. HZ almost always causes pain, and post-herpetic neuralgia is its most common complication. Half or more of hospitalised HZ patients have post-herpetic neuralgia, secondary infections, or inflammatory sequelae that are occasionally fatal. These disease burdens severely diminish patients’ quality of life and incur heavy healthcare utilisation.ConclusionsSeveral countries have abundant data on HZ, but others, especially in South-East Asia, very few. However, Asia-Pacific countries generally lack data on HZ vaccine safety, efficacy and cost-effectiveness. Physicians treating HZ and its complications in Asia-Pacific face familiar challenges but, with a vast aged population, Asia bears a unique and growing burden of disease. Given the strong rationale for prevention, most adult immunisation guidelines include HZ vaccine, yet it remains underused. We urge all stakeholders to give higher priority to adult immunisation in general and HZ in particular.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2198-y) contains supplementary material, which is available to authorized users.

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Section: Complicating Presentations and Disease Associationsmentioning

confidence: 99%

Section: Complicating Presentations and Disease Associationsmentioning

confidence: 99%

Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific

et al. 2017

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“…Since it has been reported to be elevated in various disorders, including viral meningitis [20], neuropsychiatric systemic lupus erythematosus [21], and neuro-Behçet's syndrome [22], the cerebrospinal level of this cytokine is not diagnostic, but may indicate leptomeningitis activity when serum markers are confounded by accidental systemic complications (e.g., infection). In the serum and synovial fluid of patients with RA, TNF-a levels increase along with disease activity or progression of joint destruction, respectively [23]; anti-TNF biologics now play a central role in the treatment of RA.…”

Section: Discussionmentioning

confidence: 99%

Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis: report of a case successfully treated as rheumatoid leptomeningitis

Shimada¹,

Matsui²,

Kawakami³

et al. 2009

Modern Rheumatology

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A case of biopsy-confirmed chronic leptomeningitis complicating rheumatoid arthritis in a 53-year old female is reported. Her symptoms included weight loss, severe depression, and pyrexia. Magnetic resonance imaging was useful in diagnosis. Intravenous methylprednisolone was prescribed (1 g/day for 3 days), followed by prednisolone (initial dose of 30 mg daily), and this treatment was effective. Her IgG-index, serum levels of soluble interleukin-2 receptor and ferritin, and cerebrospinal level of interleukin-6 paralleled her clinical course.

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“…At present, the most successful and robust multiplexing technology is Luminex xMAP platform, which combines advanced fluidics, optics, and digital signal processing with proprietary microsphere technology to deliver multiplexed assay capabilities. Importantly, Luminex is an open technology and numerous companies have marketed the Luminex system, including Bio-Rad, Qiagen, Invitrogen, and Millipore ect.. And a steadily growing list of ready-to-use multiplexed immunoassays have also been provided by these companies for applications in biomarker discovery , autoimmune disease diagnostics [77][78][79][80] , infectious disease diagnostics [81][82][83][84][85][86][87][88][89][90][91][92][93] , neurological diseases [94][95][96][97][98][99][100][101] , HLA testing [102][103][104] , and drug discovery 105,106 ( Table 4).…”

Section: Applications Of Multiplexed Immunoassaysmentioning

confidence: 99%

Multiplexed Immunoassays

Zheng¹,

He²

2012

Advances in Immunoassay Technology

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Adult Meningism and Viral Meningitis, 1997-2004: Clinical Data and Cerebrospinal Fluid Cytokines

Cited by 25 publications

References 13 publications

Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific

Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific

Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis: report of a case successfully treated as rheumatoid leptomeningitis

Multiplexed Immunoassays

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