Adult intensive-care patients with 2009 pandemic influenza A(H1N1) infection

Fuhrman, C.; Bonmarin, Isabelle; Bitar, Dounia; Cardoso, Teresa; Duport, Nicolas; Herida, Magid; Isnard, H.; Guidet, Bertrand; Mimoz, Olivier; Richard, Jean‐Christophe; Brun‐Buisson, C.; Brochard, Laurent; Mailles, Alexandra; Paty, A.-C.; Saura, C.; Lévy-Brühl, Daniel

doi:10.1017/s0950268810002414

Cited by 48 publications

(47 citation statements)

References 18 publications

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“…A majority of hospitalized patients requiring therapy in ICUs were adults <65 years who on admission had respiratory failure due mainly to primary influenza pneumonia in agreement with other observations,8, 15, 21, 22, 23, 24 and in clear contrast to seasonal influenza. The number of patients that are admitted to an ICU may vary related to criteria used by the institution.…”

Section: Discussionsupporting

confidence: 90%

“…The number of patients that are admitted to an ICU may vary related to criteria used by the institution. Consequently, the mortality in ICU differs has been reported from 11% to 25% 15, 21, 22, 23, 24, 25. Many patients with severe disease have co‐morbidities, but it is well described that fatalities from pandemic influenza may occur in previously healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

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The first, second and third wave of pandemic influenza A (H1N1)pdm09 in North Denmark Region 2009–2011: a population‐based study of hospitalizations

Ørsted

Mølvadgaard

Nielsen

et al. 2013

Influenza Resp Viruses

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Background and objectivesDenmark experienced three waves of the new pandemic influenza A (H1N1)pdm09 from July 2009 to February 2011. The aim of the study was to describe the epidemiology and clinical characteristics of hospitalized patients in a defined population of North Denmark Region with a mixed urban and rural community of 579 000 inhabitants.MethodsReview of medical records of all hospitalized patients with confirmed influenza A from July 2009 to February 2011.ResultsTwo hundred and seventy‐three patients were admitted to hospital. The age‐related population incidences of hospitalization were as follows: 0–14 years: 111/100 000, 15–64 years: 39/100 000, and ≥65 years: 17/100 000. During the first wave (July 2009–August 2009), three patients were admitted – none received treatment in intensive care units (ICUs), during the second wave (October 2009–January 2010), 158 patients were admitted – nine received treatment in ICUs, and during the third wave (December 2010–February 2011), 112 patients were admitted – 25 received treatment in ICUs. Fourteen patients (5%) died within 30 days of diagnosis (median 55 years; range 14–76 years) and additional seven patients (2·6%) died within 365 days (median 25 years; range 1–86 years).ConclusionsPatients hospitalized with pandemic influenza A (H1N1)pdm09 were predominantly children and younger adults, and only a few patients were >65 years. The third wave was the most severe taking the number and percentage of patients admitted to ICUs and 30‐day mortality into consideration. We observed that the incidence of hospitalizations as well as clinical severity among younger adults did not decline from the second to the third wave.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

The first, second and third wave of pandemic influenza A (H1N1)pdm09 in North Denmark Region 2009–2011: a population‐based study of hospitalizations

Ørsted

Mølvadgaard

Nielsen

et al. 2013

Influenza Resp Viruses

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“…Le registre de l'InVS a recensé 1 065 patients de plus de 15 ans, hospitalisés en réanimation et infectés par la grippe A(H1N1), entre juillet 2009 et février 2010 [1]. Le registre Reva-Grippe-SRLF comprend plus de la moitié de ces cas (Tableau 1).…”

Section: Registres Invs Et Reva-grippe-srlfunclassified

“…Les facteurs significativement associés à la ventilation méca-nique (invasive ou non invasive) en analyse multivariée sont l'obésité (odds ratio [OR] = 3,4 ; intervalle de confiance à 95 % [IC 95 %] : [1,[3][4][5][6][7][8]7] ; p = 0,012), la présence d'un acute lung injury ou d'un syndrome de détresse respiratoire aiguë (SDRA) à l'admission (OR = 18,8 ; IC 95 % : [8,7] ; p < 10 -3 ) et la gravité globale à l'admission appréciée par le score SAPS 3 (OR = 1,13 ; IC 95% : [1,09-1,18] ; p < 10 -3 , pour un point). L'asthme apparaît comme un facteur protecteur (OR = 0,19 ; IC 95 % : [0,08-0,50] ; p = 0,001) possiblement expliqué par le fait que les asthmatiques ont été majoritairement hospitalisés en réanimation pour une crise d'asthme aiguë rapidement guérie plutôt que pour une pneumopathie virale sévère.…”

Section: Facteurs Associés Au Recours à La Ventilation Artificielleunclassified

Severe H1N1 2009 influenza infection in adults: the French experience

Mercat

Pham²,

Rozé

et al. 2011

Réanimation

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Le registre Reva-Grippe-SRLF a permis de colliger les données de 562 patients infectés par le virus grippal H1N1 2009 et hospitalisés en réanimation. La mortalité globale de ces patients a été de 20 %. Le recours à la ventilation invasive, l'insuffisance cardiaque, l'immunodépres-sion étaient associés à la mortalité. Trois cent quarante et un (82 %) des 417 patients ventilés présentaient un syndrome de détresse respiratoire aiguë (SDRA). Cent soixante-neuf (30 %) présentaient une co-infection bacté-rienne. La corticothérapie était associée à une surmortalité chez les patients atteints de SDRA. Le taux d'occupation lié aux patients grippés a franchi le seuil de 15 % dans de nombreux services de réanimation. Pour citer cette revue : Réanimation 20 (2011).Mots clés Grippe · H1N1 · Pandémie · Pneumonie · Réanimation · Syndrome de détresse respiratoire aiguë · Corticoïdes · Ventilation mécanique Abstract The REVA-Flu-SRLF register allowed collection of data from 562 patients infected with H1N1 influenza virus 2009 and hospitalized in the intensive care unit (ICU). The overall mortality of these patients was 20%. The use of invasive ventilation, heart failure, and immunosuppression were associated with mortality. Three hundred forty-one (82%) among the 417 mechanically ventilated patients had an acute respiratory distress syndrome (ARDS). One hundred sixty-nine (30%) had a bacterial co-infection. Corticosteroid therapy was associated with an increased mortality in patients with ARDS. The occupancy rate associated with influenza patients crossed the threshold of 15% in many ICUs. To cite this journal: Réanimation 20 (2011).

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“…During the last pandemic, experience in the management of the most severely affected patients with influenza A (H1N1)-related acute respiratory distress syndrome (ARDS) included increased use of extracorporeal membrane oxygenation (ECMO) [1,2]. Growing interest in this technique has been spurred by the results of a large cohort study in which transfer to an ECMO center was associated with lower hospital mortality than matched non-ECMO-referred patients [3].…”

mentioning

confidence: 99%