Adult IDH Wild-Type Glioblastoma Ultrastructural Investigation Suggests a Possible Correlation between Morphological Biomarkers and Ki-67 Index

Familiari, Pietro; Relucenti, Michela; Lapolla, Pierfrancesco; Palmieri, Mauro; Antonelli, Manila; Cristiano, Loredana; Barbaranelli, Claudio; D’Angelo, Luca; Familiari, Giuseppe; Santoro, Antonio; Frati, Alessandro; Bruzzaniti, Placido

doi:10.3390/biomedicines11071968

Cited by 2 publications

(2 citation statements)

References 95 publications

(102 reference statements)

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“…We could confirm these findings in our study; concerning the complete cohort, higher Ki-67 values were not significantly associated with worse OS [OR: 0.21; 95% CI: 0.12-1.31; p = 0155]. Overall, Ki-67 proliferation indices seem to be valuable in some settings, e.g., differential diagnostic settings; however, they should not be over-interpreted in the clinical context [39].…”

Section: Os Pfs Mgmt Methylation and Ki-67 Proliferation Indexsupporting

confidence: 81%

Treatment Strategies for Glioblastoma in the Elderly: What Should We Focus on Compared to Younger Patients

Gull,

Von Riegen,

Beckmann

et al. 2024

Cancers

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(1) Background: Although the incidence of glioblastoma (GB) has a peak in patients aged 75–84 years, no standard treatment regimen for elderly patients has been established so far. The goal of this study was to analyze the outcome of GB patients ≥ 65 years to detect predictors with relevant impacts on overall survival (OS) and progression-free survival (PFS). (2) Methods: Medical records referred to our institution from 2006 to 2020 were analyzed. Adult GB patients with clinical data, postoperative MRI data, and ≥1 follow-up investigation after surgical resection were included. The complete cohort was divided into a younger (<65) and an elderly group (≥65 years). Multiple factors regarding OS and PFS were scanned using univariate and multivariable regression with p < 0.05. (3) Results: 1004 patients were included with 322 (61.0%) male individuals in the younger and 267 (56.1%) males in the older cohort. The most common tumor localization was frontal in both groups. Gross total resection (GTR) was the most common surgical procedure in both groups, followed by subtotal resection (STR) (145; 27.5%) in the younger group, and biopsy (156; 32.8%) in the elderly group. Multivariate analyses detected that in the younger cohort, MGMT promoter methylation and GTR were predictors for a longer OS, while MGMT methylation, GTR, and hypofractionated radiation were significantly associated with a longer OS in the elderly group. (4) Conclusions: Elderly patients benefit from surgical resection of GB when they show MGMT promoter methylation, undergo GTR, and receive hypofractionated radiation. Furthermore, MGMT methylation seems to be associated with a longer PFS in elderly patients. Further investigations are required to confirm these findings, especially within prospective radiation therapy studies and molecular examinations.

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Section: Os Pfs Mgmt Methylation and Ki-67 Proliferation Indexsupporting

confidence: 81%

Treatment Strategies for Glioblastoma in the Elderly: What Should We Focus on Compared to Younger Patients

Gull,

Von Riegen,

Beckmann

et al. 2024

Cancers

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“…According to data from the medical literature, genetic and molecular factors have been described to play a role in the diagnosis and prognosis of these lesions and in the effect on the invasive nature of the tumour. These include ATRX or p53 mutation [41]. Current studies have found that there is an association between IDH-1 mutations and ATRX mutations.…”

Section: Discussionmentioning

confidence: 99%

General Clinico-Pathological Characteristics in Glioblastomas in Correlation with p53 and Ki67

Sipos,

Kövecsi,

Ovidiu-Ioan

et al. 2023

Medicina

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Introduction: A glioblastoma is an intra-axial brain tumour of glial origin that belongs to the category of diffuse gliomas and is the most common malignant neoplasia of the central nervous system. The rate of survival at 5 years, from the moment of diagnosis, is not higher than 10%. Materials and methods: In this retrospective study, fifty-four patients diagnosed with glioblastoma, from the Pathology Department of the County Emergency Clinical Hospital of Târgu Mureș, between 2014 and 2017 were included. We studied the clinico-pathological data (age, gender, location, and laterality) and, respectively, the immunoexpression of p53, Ki67, ATRX, and IDH-1 proteins. Results: We observed a statistically significant association between the laterality of the tumour according to the age groups, with the localization on the right side being more frequent in the age group below 65 years of age, while the involvement of the left hemisphere was more prevalent in those over 65 years. Out of the total 54 cases, 87.04% were found to be primary glioblastomas; more than 70% of the cases were ATRX immunopositive; almost 80% of the glioblastomas studied had wild-type p53 profile; and 35% of the cases were found to have a Ki67 index greater than 20%. A statistically significant association between gender and ATRX mutation was found; female cases were ATRX immunopositive in 92% of the cases. Almost 70% of the cases were both IDH-1 and p53 wild-type, and we observed the presence of both mutations in only 3.7% of the cases. Approximately 83% of primary glioblastomas were ATRX positive, respectively, and all IDH-1 mutant cases were ATRX negative. Conclusions: Glioblastomas still represent a multidisciplinary challenge considering their reserved prognosis. In this study, we described the most common clinico-pathological characteristics and IHC marker expression profiles, highlighting a variety of percentage ranges in primary and secondary glioblastomas. Given the small number of studied cases, further prospective studies on larger cohorts are needed in the future to evaluate the role of these immunohistochemical markers as prognostic factors for survival or recurrence.

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Adult IDH Wild-Type Glioblastoma Ultrastructural Investigation Suggests a Possible Correlation between Morphological Biomarkers and Ki-67 Index

Cited by 2 publications

References 95 publications

Treatment Strategies for Glioblastoma in the Elderly: What Should We Focus on Compared to Younger Patients

Treatment Strategies for Glioblastoma in the Elderly: What Should We Focus on Compared to Younger Patients

General Clinico-Pathological Characteristics in Glioblastomas in Correlation with p53 and Ki67

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