Abstract:Eleven patients with adult Hirschsprung's disease were treated at Seoul National University Hospital (SNUH, 8 cases) and Chosun University Hospital (CUH, 3 cases) between 1985 and 1992. Of the 11 patients, seven were male. The age of the patients ranged from 11 to 30 years, and all presented with chronic constipation and recurrent faecal impactions that required periodic enemas and laxatives. The Duhamel's operation, as a single or staged procedure, was performed in all patients. Levels of aganglionosis in 9 p… Show more
“…Age at operation was 12.6±1.9 years (range [11][12][13][14][15][16][17][18][19][20][21][22]. Operating time was 121±19.9 min (range 90-150).…”
Section: Resultsmentioning
confidence: 99%
“…Eventually, the dilated colon is no longer able to propel the feces distally. The term adult HD has been arbitrarily applied by some investigators to cases in which the patient is older than 10 years when the diagnosis is established, [11][12][13] whereas others have defined adult HD as cases in which the diagnosis was made after the age of 18 or 19 years. 14 One-stage operation is safe, cost-effective, and avoids the morbidity of stomas.…”
“…Age at operation was 12.6±1.9 years (range [11][12][13][14][15][16][17][18][19][20][21][22]. Operating time was 121±19.9 min (range 90-150).…”
Section: Resultsmentioning
confidence: 99%
“…Eventually, the dilated colon is no longer able to propel the feces distally. The term adult HD has been arbitrarily applied by some investigators to cases in which the patient is older than 10 years when the diagnosis is established, [11][12][13] whereas others have defined adult HD as cases in which the diagnosis was made after the age of 18 or 19 years. 14 One-stage operation is safe, cost-effective, and avoids the morbidity of stomas.…”
“…[9,10] It has been recognized that STC is a heterogeneous disease with unknown etiology. Hypotheses proposed to explain STC mostly focused on the disorders of relevant nerves, the enteric nervous system particularly.…”
Rationale:Slow transit constipation (STC) is a common disease of which the etiology is still not clear. Multiple hypotheses have been proposed to explain STC, including autonomic neuropathy, disorders of the enteric nervous system and so forth. Morphological abnormalities of the enteric nerves of the colon in patients with STC have been extensively reported, while there have been no morphological reports focusing on extrinsic extramural fibers from the pelvic plexus to the distal colon (i.e., pelvic parasympathetic colonic nerve) in patients with STC.Patient concerns:Whether morphological changes of pelvic parasympathetic colonic nerve coexist with abnormalities of the enteric nerves of the colon in the patient with STC.Diagnosis:Slow transit constipation (STC).Interventions:The patient with STC underwent a partial colectomy (sigmoid colon and partial descending colon). The fibers of the myenteric plexuses within the removed colon and the myelinated fibers of the pelvic parasympathetic colonic nerve were observed under optical and electron-microscope.Outcomes:The fibers of the myenteric plexuses showed vacuolated degeneration between the muscularis propria layer under optical microscope. Myelinated fibers of the pelvic parasympathetic colonic nerve showed obvious vacuolated degeneration under electron-microscopic examination.Lessons:Such a simultaneous neuropathy in both myenteric plexuses and extrinsic extramural nerves has not been documented previously. Our finding supports the notion that neuropathy remains the most plausible explanation for STC, in which nerve dysfunction might occur by way of a degenerative process.
“…Concerning doped PZT thin films, few works have been published [2,3,4]. The effects of the donor dopants, particularly Nb, on thc properties relative to ferroelectric memories have been discussed in many recent papers [5,6].…”
Pb(Zr,Ti)O, (PZT) and Pb(Zr,Ti,Nb)03 (PNZT) thin films were grown on platinized silicon substrates by r.f. magnetron sputtering followed by a post-annealing treatment. The Niobium, Nb, concentration varied from 1 to 7 at.% by increment of 1 at.%. The effects of the Nb introduction on the PZT electrical properties, i.e, dielectric, ferroelectric and piezoelectric ones were investigated. The relative dielectric constant (4) was very sensitive to the Nb introduction; 4 reaches 1100 for a PNZT film doped at 2 at.% in comparison to 820 for a PZT film. The ferroelectric properties were also dependent of the doping level; in particular the remnant polarization reaches its maximum value for a 2 at.% Nb doped PZT film. The introduction of Nb enhances the piezoelectric properties of the films. The maximum value of d33 varied from 55 pmN for PZT films to 115 pmN for a 2 at.% Nb doped films. For this doping level, qlrern. reaches its maximum value: -4.6 C/m2. PNZT thin films, with weak Nb concentration (comprised between 1 to 2 at.%) are suitable for microsystems realization.
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