Adult hippocampal neurogenesis for systems consolidation of memory

Terranova, Joseph I.; Ogawa, Shuji; Kitamura, Takashi

doi:10.1016/j.bbr.2019.112035

Cited by 51 publications

(45 citation statements)

References 119 publications

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“…2d) fit well with a concomitant reduction in the occurrence, duration and internal frequencies of sharp-wave ripples ( Fig. 2e) suggesting that neurogenesis might compensate for the characteristic hyperexcitability of the old CA3 area and ultimately control critical activity patterns underlying memory consolidation 48 . Despite the absence of a clear effect in behavioural performance during a simple conditioning test ( Fig.…”

Section: D Increases Nsc Expansion and Neurogenesis Throughout Lifesupporting

confidence: 52%

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

et al. 2020

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Functional plasticity of the brain decreases during ageing causing marked deficits in contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a prime example of hippocampal plasticity promoting the contextualisation of information and dramatically decreases during ageing. We found that a genetically-driven expansion of neural stem cells by overexpression of the cell cycle regulators Cdk4/cyclinD1 compensated the age-related decline in neurogenesis. This triggered an overall inhibitory effect on the trisynaptic hippocampal circuit resulting in a changed profile of CA1 sharp-wave ripples known to underlie memory consolidation. Most importantly, increased neurogenesis rescued the agerelated switch from hippocampal to striatal learning strategies by rescuing allocentric navigation and contextual memory. Our study demonstrates that critical aspects of hippocampal function can be reversed in old age, or compensated throughout life, by exploiting the brain's endogenous reserve of neural stem cells.

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Section: D Increases Nsc Expansion and Neurogenesis Throughout Lifesupporting

confidence: 52%

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

et al. 2020

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“…Such damage would be consistent with the decrease in ECC acquisition rate in anesthesia-exposed groups. Notably, after learning the hippocampal volume on the learning-associated side significantly increased only in the control group, which may reflect normal learning-related hippocampal neurogenesis, angiogenesis 38 , 39 and increase in dendritic branching 40 that has been shown to occur in a variety of contexts. For example, previous MR studies have reported behavior-related changes in the hippocampus in humans after learning foreign language 41 , in exercising mice 42 , and spatial navigation training-modified hippocampal volumes in humans that protected the hippocampus against age-related volume declines 43 .…”

Section: Discussionmentioning

confidence: 92%

Effects of neonatal isoflurane anesthesia exposure on learning-specific and sensory systems in adults

Aksenov

Venkatasubramanian

Miller

et al. 2020

Sci Rep

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Millions of children undergo general anesthesia each year, and animal and human studies have indicated that exposure to anesthesia at an early age can impact neuronal development, leading to behavioral and learning impairments that manifest later in childhood and adolescence. Here, we examined the effects of isoflurane, a commonly-used general anesthetic, which was delivered to newborn rabbits. Trace eyeblink classical conditioning was used to assess the impact of neonatal anesthesia exposure on behavioral learning in adolescent subjects, and a variety of MRI techniques including fMRI, MR volumetry, spectroscopy and DTI captured functional, metabolic, and structural changes in key regions of the learning and sensory systems associated with anesthesia-induced learning impairment. Our results demonstrated a wide array of changes that were specific to anesthesia-exposed subjects, which supports previous studies that have pointed to a link between early anesthesia exposure and the development of learning and behavioral deficiencies. These findings point to the need for caution in avoiding excessive use of general anesthesia in young children and neonates.

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“…Recently, the hippocampus and the cortex are the key functional locations in the brain ( Yin et al, 2018 ; Han et al, 2019 ; Terranova et al, 2019 ; Vijayakumar et al, 2019 ). Long-term neurodegeneration results from deficits in the cortex and the hippocampus, which induces brain damage ( Arulsamy et al, 2019 ; Kempuraj et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Analysis of Hippocampus and Cortex in a Rat Model of Traumatic Brain Injury in the Subacute Phase

Zheng

Zhou

et al. 2020

Front. Neurosci.

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Traumatic brain injury (TBI) is a complex and serious disease as its multifaceted pathophysiological mechanisms remain vague. The molecular changes of hippocampal and cortical dysfunction in the process of TBI are poorly understood, especially their chronic effects on metabolic profiles. Here we utilize metabolomics-based liquid chromatography coupled with tandem mass spectrometry coupled with bioinformatics method to assess the perturbation of brain metabolism in rat hippocampus and cortex on day 7. The results revealed a signature panel which consisted of 13 identified metabolites to facilitate targeted interventions for subacute TBI discrimination. Purine metabolism change in cortical tissue and taurine and hypotaurine metabolism change in hippocampal tissue were detected. Furthermore, the associations between the metabolite markers and the perturbed pathways were analyzed based on databases: 64 enzyme and one pathway were evolved in TBI. The findings represented significant profiling changes and provided unique metabolite–protein information in a rat model of TBI following the subacute phase. This study may inspire scientists and doctors to further their studies and provide potential therapy targets for clinical interventions.

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Adult hippocampal neurogenesis for systems consolidation of memory

Cited by 51 publications

References 119 publications

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

Effects of neonatal isoflurane anesthesia exposure on learning-specific and sensory systems in adults

Metabolomics Analysis of Hippocampus and Cortex in a Rat Model of Traumatic Brain Injury in the Subacute Phase

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