Adult Hepatitis B Virus Vaccination Coverage in China from 2011 to 2021: A Systematic Review

Bai, Xinxin; Chen, Lu; Liu, Xinyao; Tong, Yujia; Wang, Lu; Zhou, Minru; Liu, Yanming; Hu, Guangyu

doi:10.3390/vaccines10060900

Cited by 12 publications

(13 citation statements)

References 30 publications

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“…Although vaccination against HBV has greatly reduced the infection rate, there are still 5–10% of the population that remains unprotected due to waned immunity over time [ 4 ]. In addition, the limited vaccination coverage is accountable for a major portion of new HBV infections [ 5 ]. Currently, approximately 257 million people are living with chronic HBV infection and 25 – 40% % of them have the lifetime risk of developing adverse outcomes HCC or cirrhosis [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway

Zeng

Pang

et al. 2023

Infect Agents Cancer

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Background Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) does not respond well to current treatment options like sorafenib, and there is an urgent need for developing therapeutical strategies for HBV + HCC. Brassicasterol has previously shown anti-cancer and anti-viral activities, however, its value against HBV + HCC remains to be explored. Methods The inhibitory effect of brassicasterol and sorafenib was evaluated on HBV + HCC cell lines and xenograft mouse model. The cytotoxicity of brassicasterol on normal liver cells were measured by LDH assay. AKT agonist was used to identify the targeted signaling pathway by brassicasterol. Results Brassicasterol induced HBV + HCC cell death in a both dose-dependent and time-dependent manner, and such inhibition was more potent than sorafenib. Brassicasterol did not show apparent cytotoxicity to normal liver cells. Xenograft mouse model further confirmed the inhibitory effect of brassicasterol on the growth of HBV + HCC. Furthermore, signaling pathway analysis showed that brassicasterol-treated HBV + HCC cells had decreased level of phosphor-AKT expression while the addition of AKT agonist could counteract the inhibitory effect of brassicasterol on HCC, indicating that brassicasterol suppressed AKT pathway to exhibit anti-cancer activity in HBV + HCC cells. In addition, brassicasterol showed similar levels of inhibition on HBV− and HBV + HCC cells. Conclusion Brassicasterol possesses anti-cancer activity against HCC through the downregulation of AKT pathway and such activity is independent of HBV infection.

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Section: Introductionmentioning

confidence: 99%

Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway

Zeng

Pang

et al. 2023

Infect Agents Cancer

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“…Nevertheless, when better dissecting the vaccination rates among household contacts of Chinese patients, we found a practical universal coverage in relatives born in Spain (where HBV vaccination is universal since 1991), compared to rates below 60% in those born in China. The latter re ects the lower vaccination coverage in China in the adult population (19). Thus, results from our study emphasize the need to (20) further promote vaccination among this group of individuals at risk.…”

Section: Discussionmentioning

confidence: 57%

Influence of language barrier and cultural background in Hepatitis B disease knowledge in a Chinese community of Spain.

Pocurull,

Tapias,

Wang

et al. 2023

Preprint

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Background Hepatitis B infection is prevalent in patients of Asian origin. Due to language barriers and cultural differences, it is not always straightforward to evaluate disease knowledge in the liver clinics. We aimed to assess the current awareness on HBV (Hepatits B virus) infection and its mechanisms of transmission in HBV-infected Chinese patients and their household contacts. Methods HBV-infected Chinese patients and their household contacts were interviewed by a nurse (Chinese or native) about their knowledge on hepatitis B transmission mechanisms, use of preventive measures and vaccination status. Non-Chinese HBV-infected patients were defined as a control group. Results A total of 182 patients and 398 relatives/household contacts participated in the study. Eighty-five (48%) patients and 240 (60%) of household contacts were from China. Language barrier was documented in 80% of Chinese patients and 44% of their household contacts. Knowledge on parenteral and sexual HBV transmission was high (90%) in both groups of patients. However, Chinese patients were significantly more aware of vertical transmission (94% vs 68%, p < 0.01) and were more forewarned in the use of parenteral transmission measures (93% vs 74%; p < 0.01). No differences in preventive sexual measures were detected. Despite being less knowledgeable on horizontal and sexual HBV transmission compared to controls (86% vs 96% for parenteral; 81% vs 95% for sexual, p < 0.01),Chinese household contacts used preventive measures more frequently (79% vs 65% for horizontal transmission, p < 0.01). Vaccination coverage was lower in Chinese (78%) compared to control (86%) household contacts although the difference did not reach statistical significance. Conclusions Despite relevant language barriers, Chinese HBV-infected patients are well informed on the mechanisms of HBV transmission, particularly on the vertical route. Cultural differences may explain a higher use of preventive measures among the Chinese population. HBV vaccination of household contacts should be reinforced in both groups of individuals.

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“…Nevertheless, when better dissecting the vaccination rates among household contacts of Chinese patients, we found a practical universal coverage in relatives born in Spain (where HBV vaccination is universal since 1991), compared to rates below 60% in those born in China. The latter reflects the lower vaccination coverage in China in the adult population ( 21 ). Thus, results from our study emphasize the need to ( 22 ) further promote vaccination among this group of individuals at risk.…”

Section: Discussionmentioning

confidence: 99%

Influence of language barrier and cultural background in hepatitis B disease knowledge in a Chinese community of Spain

Pocurull,

Collazos,

Miralpeix

et al. 2024

Front. Public Health

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IntroductionHepatitis B infection (HBV) is prevalent in China. Due to language barriers and cultural differences, it is not always straightforward to evaluate disease knowledge in liver clinics. We aimed to assess the awareness on HBV and its mechanisms of transmission in HBV-infected Chinese patients and their household contacts.MethodsHBV-infected Chinese patients and their contacts were interviewed by a native Chinese nurse regarding their knowledge on HBV transmission mechanisms, use of preventive measures and vaccination status. Non-Chinese HBV-infected patients and their household contacts served as a control group.ResultsIn total 182 patients and 398 contacts participated with 85 (47%) patients and 240 (60%) contacts being from China. Language barrier was reported in 80% of Chinese patients and 44% of their contacts. Knowledge on parenteral and sexual HBV transmission was high in all patients (~90%) but Chinese were more aware of vertical transmission than controls (94% vs. 68%; p < 0.01). Regarding the use of preventive measures, Chinese patients were more forewarned in their use to avoid parenteral transmission (93% vs. 74%, p < 0.01). When assessing household contacts, Chinese used preventive measures more frequently than controls for parenteral and sexual transmission (79% vs. 65 and 81% vs. 48%, p < 0.05). Vaccination coverage was slightly lower in Chinese contacts compared to controls (78% vs. 86%, p = 0.05).ConclusionDespite relevant language barriers, Chinese patients are well informed on the mechanisms of HBV transmission. Cultural differences may explain a higher use of preventive measures among the Chinese population. HBV vaccination of household contacts should be reinforced in both groups.

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Adult Hepatitis B Virus Vaccination Coverage in China from 2011 to 2021: A Systematic Review

Cited by 12 publications

References 30 publications

Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway

Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway

Influence of language barrier and cultural background in Hepatitis B disease knowledge in a Chinese community of Spain.

Influence of language barrier and cultural background in hepatitis B disease knowledge in a Chinese community of Spain

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