Adult height of children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Tsai, Meng-Ju Melody; Tsai, Wen-Fa; Lee, Cheng-Ting; Liu, Shih-Yao; Chien, Yin‐Hsiu; Tung, Yung-Liang

doi:10.1016/j.jfma.2022.09.007

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Tsai et al. 3 evaluated the adult height of Taiwanese children with 21-OHD and the effect of a gonadotropin-releasing hormone analogue (GnRHa) in patients with central precocious puberty (CPP) complicating 21-OHD. Of 116 patients with 21-OHD, 90 who had attained adult height were subjected to an analysis of height outcomes.…”

Section: Adult Height Of Children With Congenital Adrenal Hyperplasiamentioning

confidence: 99%

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Kao¹

2023

Journal of the Formosan Medical Association

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Section: Adult Height Of Children With Congenital Adrenal Hyperplasiamentioning

confidence: 99%

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Kao¹

2023

Journal of the Formosan Medical Association

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Anthropometric Measures Among Children and Teens With Classic 46,xx Congenital Adrenal Hyperplasia in Relation to Improvements in Diagnosis and Care

McCracken,

Kaabi,

Crawford

et al. 2024

Endocrine Practice

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Impact of Newborn Screening on Adult Height in Patients With Congenital Adrenal Hyperplasia (CAH)

Hoyer‐Kuhn

Eckert

Binder

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Treatment of children with classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is challenging. Linear growth and adult height are compromised according to recent publications. However, most of these data were obtained in the era before CAH newborn screening. Design Body height of patients with classical CAH diagnosed before and after the establishment of newborn screening were analyzed retrospectively. Patients and Methods We identified 600 patients with classical CAH (227 male) with data on near-adult height (NAH), target height (TH), and information on newborn screening from the electronic German CAH registry (DGPAED society). Newborn screening was performed in 101 (16.8%) patients. All patients received hydrocortisone with or without fludrocortisone. To assess the effects of newborn screening, a linear regression model adjusted/stratified for sex and phenotype was used (SAS 9.4). Results TH corrected NAH (mean; 95% confidence interval) was closer to zero in patients with CAH and newborn screening (-0.25 SDS; -0.44 - -0.06) than in patients without newborn screening (-0.44 SDS; -0.52 - -0.36) (p=0.069). Screening had no effect on NAH in female patients. In male patients, NAH was significantly better (p=0.033) with screening than without screening. After stratifying for CAH phenotype, screening did not affect the NAH of patients with Salt-wasting-CAH. Patients with Simple-virilizing-CAH had a significantly better cNAH (p=0.034) with screening (0.15 SDS; -0.28 - 0.59) than without screening (-0.35 SDS; -0.52 - -0.18). Conclusions Our data suggest that newborn screening might be associated with improved near-adult height in male CAH patients and in patients with SV-CAH.

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Adult height of children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Cited by 3 publications

References 27 publications

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Anthropometric Measures Among Children and Teens With Classic 46,xx Congenital Adrenal Hyperplasia in Relation to Improvements in Diagnosis and Care

Impact of Newborn Screening on Adult Height in Patients With Congenital Adrenal Hyperplasia (CAH)

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