Adult Form of Chronic Porphyria With Cutaneous Manifestations

Porfiria cutânea tardia

“…5 Alcohol -alcoholism has been acknowledged as an important triggering factor of PCT. 47 Since most of the alcoholics do not develop PCT, it is clear that alcohol only acts in synergism with other factors in predisposed subjects. 48 This is possibly linked to the inheritance of mutations associated to hemochromatosis (Cys282Tyr).…”

Porphyria Cutanea Tarda (PCT) experience in Victoria, Australia

“…13 It is theorized that ethanol is a UROD inhibitor and an inducer of early enzymes in heme biosynthesis pathway.…”

The porphyrias: a review.

“…Although Waldenstrbm recognized that attacks of abdominal pain were occasionally a feature of 'porphyria cutanea tarda', subjects with cutaneous symptoms were never found amongst families with typical acute intermittent porphyria. Subsequent reports established that 'porphyria cutanea tarda' was predominantly a disease of men over the age of 40, who frequently gave a history of alcoholism and showed evidence of liver dysfunction and that both attacks of acute porphyria and a family history of porphyria were uncommon in this group (Szodoray and Sumegi, 1944;Brunsting, Mason, and Aldrich, 1951;Brunsting, 1954). However, there were also accounts of a less common cutaneous porphyria in which both photosensitivity and acute attacks occurred (Gray, Rimington, and Thomson, 1948;Watson, 1951 ;MacGregor, Nicholas, and Rimington, 1952;Rimington, 1952;Calvert and Rimington, 1953;Discombe and Treip, 1953;Wells and Rimington, 1953;Holti, Rimington, Tate, and Thomas, 1958).…”