Adult extracardiac rhabdomyoma: Light and immunohistochemical studies of two cases in the parapharyngeal space

Bjørndal, Kristine; Godballe, Christian; Østergaard, Birthe; Krogdahl, Annelise

doi:10.1002/hed.20358

Cited by 14 publications

(4 citation statements)

References 7 publications

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“…Adult rhabdomyoma is a rare benign tumor of striated muscle and most commonly (90%) occurring in the head and neck region. 5 However, it has also been reported in other locations such as esophagus and extremities. 6,7 It is usually more often diagnosed in adult male over 40-yearold with a median age of 60-year-old.…”

Section: Discussionmentioning

confidence: 98%

Pitfalls in the diagnosis of adult rhabdomyoma by fine needle aspiration: Report of a case and a brief literature review

Jin

Saleh

2009

Diagnostic Cytopathology

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Fine needle aspiration (FNA) is a valuable, noninvasive, commonly used technique in the diagnoses of head and neck tumors. Adult rhabdomyoma is a rare benign tumor of striate muscle tissue usually located in the head and neck region. Cytomorphologically, the tumor cells have eosinophilic finely granular cytoplasm, which sometimes can mimic other tumors. We report a case of adult rhabdomyoma, which was initially misinterpreted as granular cell tumor on FNA biopsy due to lacking of typical cytological features of adult rhabdomyoma. We recommend that adult rhabdomyoma should be included in differential diagnoses when the cytological features are suggestive of granular cell tumor. A panel of immunohistochemical stains including S100, desmin, and myoglobulin may also be helpful in making correct diagnosis.

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Section: Discussionmentioning

confidence: 98%

Pitfalls in the diagnosis of adult rhabdomyoma by fine needle aspiration: Report of a case and a brief literature review

Jin

Saleh

2009

Diagnostic Cytopathology

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“…Adult rhabdomyomas are rare, benign mesenchymal tumors of skeletal muscle origin which usually present as a solitary mass in the head and neck region. To date, there are very few case reports of rhabdomyoma diagnosed based on cytology (Table ) . In a review of the literature, the most common location is the oropharyngeal area with only 1 case located in the parapharyngeal region .…”

Section: Discussionmentioning

confidence: 99%

Cytologic findings of an adult rhabdomyoma in the parapharyngeal space: A report of a case and review of the literature

Dermawan

Doxtader

Chute

et al. 2017

Diagnostic Cytopathology

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Adult extracardiac rhabdomyomas are rare benign mesenchymal tumor arising from skeletal muscle. While they are often located in the larynx and pharynx, the incidence in the parapharyngeal area is extremely rare with only 1 documented cytology case report to date. We report a case of an adult extracardiac rhabdomyoma in the parapharyngeal space diagnosed cytologically with subsequent histologic confirmation. The patient is a 57-year-old man with history of weight loss, hematuria, dysphagia, and airway encroachment. Computerized tomography of his abdomen showed a large left renal mass. While the patient was in the operating room for the resection of his renal mass, a fine-needle aspiration from left the parapharyngeal mass was performed. The smears showed uniform bland polygonal cells with abundant eosinophilic cytoplasm and peripherally located nuclei. Immunohistochemical stains performed on the cell block showed the tumor cells were desmin positive and negative for S-100 and PAX-8, supporting the diagnosis of an adult rhabdomyoma. Subsequent resection of the mass confirmed the diagnosis of an adult extracardiac rhabdomyoma.

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“…Rarely, rhabdomyomas have been found to be located in the extremities, esophagus, stomach, mediastinum, orbit, prostate, and heart [11]. Symptoms, which are nonspecific, depend on the localization and the size of the tumor [2]. Occasionally, when lesions involve the oral cavity and oral pharynx, a mass in the throat may be observed.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically the AR presents polygonal cells, eosinophilic granular cytoplasm, cross-striations, and spider cells; the expression of desmin, muscle-specific actin, myoglobin, and myogenin can be immunohistochemically demonstrated [1]. The most important differential diagnoses are granular cell tumors, hibernomas, oncocytomas, and paragangliomas, but all these tumors do not histologically present cross-striation and do not content glycogen [2]. FR is rarer than AR; it is histologically characterized by small eosinophilic cells, sometimes with cross-striations, rare nucleoli, and the same immunohistochemical features of AR [1].…”

Section: Introductionmentioning

confidence: 99%

Voluminous Extracardiac Adult Rhabdomyoma of the Neck: A Case Presentation

Maglio

Scicchitano

Magistri

et al. 2012

Case Reports in Surgery

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Introduction. Rhabdomyomas of the head and neck are exceptionally rare benign mesenchymal tumors. Rare cases have been reported to involve other sites of the body including the head and neck regions. Case Presentation. We report a case of voluminous extracardiac adult rhabdomyoma affecting adult patients and initially seen as slowly growing, indolent neoplasms. The patient is a seventy-year old male Italian patient. Conclusion. Adult extracardiac rhabdomyoma is a rare benign tumor that may present with symptoms that vary from aerodigestive tract obstruction to remaining asymptomatic for many years. Although histology is very characteristic, several differential diagnoses have to be considered. To our knowledge, this is the first case of voluminous adult-type symptomless rhabdomyoma.

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Adult extracardiac rhabdomyoma: Light and immunohistochemical studies of two cases in the parapharyngeal space

Abstract: The head and neck area harbors 90% of adult rhabdomyomas and should be considered in a differential diagnosis in this region. Immunohistochemistry confirms that the tumors are almost totally mature neoplasms of clonal origin.

Cited by 14 publications

References 7 publications

Pitfalls in the diagnosis of adult rhabdomyoma by fine needle aspiration: Report of a case and a brief literature review

Pitfalls in the diagnosis of adult rhabdomyoma by fine needle aspiration: Report of a case and a brief literature review

Cytologic findings of an adult rhabdomyoma in the parapharyngeal space: A report of a case and review of the literature

Voluminous Extracardiac Adult Rhabdomyoma of the Neck: A Case Presentation

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