Adult cirrhosis due to untreated congenital hypopituitarism

Nyunt, Aye; Kochar, Narendra; Pilz, Daniella T; Kingham, J. G. C.; Jones, Mark T.

doi:10.1258/jrsm.98.7.316

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Many factors such as genetic background, insulin resistance, hormones secreted by adipose tissue and intestinal microbiota play certain roles in the pathogenesis of NAFLD[ 56 , 57 ]. Significantly, many reports have pointed out that hypopituitarism is related to liver changes[ 58 , 59 ]. A Japanese study reported that the prevalence of NAFLD in hypopituitary patients with GH deficiency was higher (77%) compared with controls[ 60 ].…”

Section: Psis and Liver Changesmentioning

confidence: 99%

Pituitary stalk interruption syndrome and liver changes: From clinical features to mechanisms

Wu¹,

Li²,

Chang³

2020

WJG

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Pituitary stalk interruption syndrome (PSIS) is a rare congenital abnormality characterized by thinning or disappearance of the pituitary stalk, hypoplasia of the anterior pituitary and an ectopic posterior pituitary. Although the etiology of PSIS is still unclear, gene changes and perinatal adverse events such as breech delivery may play important roles in the pathogenesis of PSIS. PSIS can cause multiple hormone deficiencies, such as growth hormone, which then cause a series of changes in the human body. On the one hand, hormone changes affect growth and development, and on the other hand, they could affect human metabolism and subsequently the liver resulting in nonalcoholic fatty liver disease (NAFLD). Under the synergistic effect of multiple mechanisms, the progression of NAFLD caused by PSIS is faster than that due to other causes. Therefore, in addition to early identification of PSIS, timely hormone replacement therapy and monitoring of relevant hormone levels, clinicians should routinely assess the liver function while managing PSIS.

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Section: Psis and Liver Changesmentioning

confidence: 99%

Pituitary stalk interruption syndrome and liver changes: From clinical features to mechanisms

Wu¹,

Li²,

Chang³

2020

WJG

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Nichtalkoholische Steatohepatitis mit Zirrhose bei jungen Erwachsenen mit hypothalamisch-hypophysärer Dysfunktion

et al. 2013

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Panhypopituitarism due to Absence of the Pituitary Stalk: A Rare Aetiology of Liver Cirrhosis

Rozas

Román

González

et al. 2016

Case Reports in Endocrinology

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Studies have established a relationship between hypothalamic-pituitary dysfunction and the onset of liver damage, which may occasionally progress to cirrhosis. Patients with hypopituitarism can develop a metabolic syndrome-like phenotype. Insulin resistance is the main pathophysiological axis of metabolic syndrome and is the causal factor in the development of nonalcoholic fatty liver disease (NAFLD). We present the case of a young patient with liver cirrhosis of unknown aetiology that was finally attributed to panhypopituitarism.

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Adult cirrhosis due to untreated congenital hypopituitarism

Cited by 3 publications

References 7 publications

Pituitary stalk interruption syndrome and liver changes: From clinical features to mechanisms

Pituitary stalk interruption syndrome and liver changes: From clinical features to mechanisms

Nichtalkoholische Steatohepatitis mit Zirrhose bei jungen Erwachsenen mit hypothalamisch-hypophysärer Dysfunktion

Panhypopituitarism due to Absence of the Pituitary Stalk: A Rare Aetiology of Liver Cirrhosis

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