Adult Cirrhosis Due to Untreated Congenital Hypopituitarism

Nyunt, Aye; Kochar, Narendra; Pilz, Daniella T; Kingham, J. G. C.; Jones, Mark T.

doi:10.1177/014107680509800708

Cited by 2 publications

(1 citation statement)

References 8 publications

(13 reference statements)

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“…The first cases establishing an association between hypothalamic-pituitary dysfunction and liver damage were reported in 2004. Most cases occur in children or adolescents who present hypothalamic dysfunction secondary to structural lesions such as perinatal asphyxia and craniopharyngiomas or genetic disorders such as Prader-Willi disease [ 1 – 3 ].…”

Section: Relationship Between Cirrhosis and Panhypopituitarismmentioning

confidence: 99%

Panhypopituitarism due to Absence of the Pituitary Stalk: A Rare Aetiology of Liver Cirrhosis

Rozas

Román

González

et al. 2016

Case Reports in Endocrinology

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Studies have established a relationship between hypothalamic-pituitary dysfunction and the onset of liver damage, which may occasionally progress to cirrhosis. Patients with hypopituitarism can develop a metabolic syndrome-like phenotype. Insulin resistance is the main pathophysiological axis of metabolic syndrome and is the causal factor in the development of nonalcoholic fatty liver disease (NAFLD). We present the case of a young patient with liver cirrhosis of unknown aetiology that was finally attributed to panhypopituitarism.

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Section: Relationship Between Cirrhosis and Panhypopituitarismmentioning

confidence: 99%

Panhypopituitarism due to Absence of the Pituitary Stalk: A Rare Aetiology of Liver Cirrhosis

Rozas

Román

González

et al. 2016

Case Reports in Endocrinology

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Endocrine and liver interaction: the role of endocrine pathways in NASH

Loria

Carulli

Bertolotti

et al. 2009

Nat Rev Gastroenterol Hepatol

142

114

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This article reviews evidence that causally links hormonal disorders with hepatobiliary disease, and gives particular focus to nonalcoholic steatohepatitis (NASH). The downstream mechanisms by which endocrine disturbances cause liver disease might be similar to those involved in the development of primary liver disease. Hypothyroidism, for example, might lead to NASH, cirrhosis and potentially liver cancer via the development of hyperlipidemia and obesity. Patients with growth hormone deficiency have a metabolic-syndrome-like phenotype that is also associated with the development of NASH. Polycystic ovary syndrome is a common endocrine disorder that is often associated with insulin resistance, the metabolic syndrome, altered levels of liver enzymes and the development of NASH. Recent findings support a role of dehydroepiandrosterone sulfate deficiency in the development of advanced NASH. In addition, adrenal failure is increasingly reported in patients with end stage liver disease and in patients who have received a liver transplant, which suggests a bidirectional relationship between liver and endocrine functions. Clinicians should, therefore, be aware of the potential role of endocrine disorders in patients with cryptogenic liver disease and of the effects of liver function on the endocrine system.

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Adult Cirrhosis Due to Untreated Congenital Hypopituitarism

Abstract: Hypopituitarism is a diagnosis to be considered in unexplained neonatal hepatitis. 1-3 Little is known about the possibility of long-term liver damage.

Cited by 2 publications

References 8 publications

Panhypopituitarism due to Absence of the Pituitary Stalk: A Rare Aetiology of Liver Cirrhosis

Panhypopituitarism due to Absence of the Pituitary Stalk: A Rare Aetiology of Liver Cirrhosis

Endocrine and liver interaction: the role of endocrine pathways in NASH

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