Extant communication research investigating illnesses highlights the importance of benefits garnered from established relationships, such as social support. Yet, less is known about how illness impacts the development of new relationships. Thus, two commonly researched pervasive illnesses were selected (HIV and cancer) to discover how they impact forecasted relational outcomes. Using predicted outcome value theory (Sunnafrank, 1986), a convenience sample (average age of less than 20) assessed POV judgments and anticipated communication (anticipated amount of communication, information seeking, and intimacy) of a hypothetical target. It was found that POV judgments were significantly lower for HIVþ targets compared to cancer stricken and healthy targets. Yet, in contrast to POV judgments, significantly more communication was anticipated with a cancer-stricken individual compared to a healthy individual. Implications for illness and POV research are discussed.Individuals suffering from potentially life-threatening illnesses face a number of challenges. Most apparent is the fear and uncertainty related to their illness and mortality. Similarly, these individuals face daily challenges in the form of taking medication that may make them sick, financial adversities related to financing their health, fatigue, and an overall change in lifestyle. These hardships explain why sick individuals seek out the benefits offered from interpersonal relationships. Particularly, a number of studies indicate that the social support from existing relationships is a cherished and vital resource for sick individuals (e.g.Although prior research on sick individuals has highlighted the importance of support, how individuals disclose their sickness (e.g., Caughlin, Bute, et al., in press;Caughlin, Brashers, et al., 2008), how individuals make sense of their sickness identity (Harwood & Sparks, 2003), and how individuals manage illness-related uncertainty (e.g., Brashers et al., 2000), less research has focused on how sickness impacts new relational development. That is, prior work is rich in elucidating the importance of established relationships for sick individuals, but scholars are yet to fully focus on how illness impacts the development of new relationships. Thus, this study seeks to discover how learning of an illness impacts beliefs about future relational development.