Adult blood vessels restore host hematopoiesis following lethal irradiation

Montfort, M. J.; Olivares, Christopher R; Mulcahy, Jean M.; Fleming, William H.

doi:10.1016/s0301-472x(02)00813-5

Cited by 38 publications

(33 citation statements)

References 30 publications

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“…Our group and others have previously demonstrated the utility of ECs in enhancing hematopoietic recovery and safeguarding HSPCs following irradiation (37,(43)(44)(45)(46)52). In these experiments, repeated i.v.…”

Section: Methodsmentioning

confidence: 98%

“…ECs generated from a number of hematopoietic and nonhematopoietic tissues have been used to demonstrate their therapeutic potential following irradiative hematopoietic insult (37,(44)(45)(46). We have previously shown that infusion of young niche-specific BM-derived ECs into young recipients following radiation-and chemo therapy-mediated myeloablative injury promotes rapid and efficient regeneration of the hematopoietic system by reducing the duration of pancytopenias and safeguarding HSC function (37,43).…”

Section: Infusion Of Aged Ecs Promotes a Myeloid Bias In Vivomentioning

confidence: 99%

See 1 more Smart Citation

Endothelial transplantation rejuvenates aged hematopoietic stem cell function

Poulos¹,

Ramalingam

Gutkin

et al. 2017

Journal of Clinical Investigation

117

105

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Section: Methodsmentioning

confidence: 98%

Section: Infusion Of Aged Ecs Promotes a Myeloid Bias In Vivomentioning

confidence: 99%

Endothelial transplantation rejuvenates aged hematopoietic stem cell function

Poulos¹,

Ramalingam

Gutkin

et al. 2017

Journal of Clinical Investigation

117

105

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“…73 In addition to the conclusions drawn from arterial ring experiments, 30,39 three murine studies have used traditional hematopoietic assays to more definitively validate the existence of postnatal vascular wall hematopoietic progenitor cells (Table 3). 10,11,79 More than a decade ago, Montfort et al interpreted that vascular intima contains proliferative cells with hematopoietic capacity, after observing long-term chimers for CD3…”

Section: Vascular Wall Hematopoietic Progenitor Cellsmentioning

confidence: 99%

Vascular Wall Progenitor Cells in Health and Disease

Psaltis

Simari

2015

Circulation Research

172

155

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The vasculature plays an indispensible role in organ development and maintenance of tissue homeostasis, such that disturbances to it impact greatly on developmental and postnatal health. Although cell turnover in healthy blood vessels is low, it increases considerably under pathological conditions. The principle sources for this phenomenon have long been considered to be the recruitment of cells from the peripheral circulation and the re-entry of mature cells in the vessel wall back into cell cycle. However, recent discoveries have also uncovered the presence of a range of multipotent and lineage-restricted progenitor cells in the mural layers of postnatal blood vessels, possessing high proliferative capacity and potential to generate endothelial, smooth muscle, hematopoietic or mesenchymal cell progeny. In particular, the tunica adventitia has emerged as a progenitor-rich compartment with niche-like characteristics that support and regulate vascular wall progenitor cells. Preliminary data indicate the involvement of some of these vascular wall progenitor cells in vascular disease states, adding weight to the notion that the adventitia is integral to vascular wall pathogenesis, and raising potential implications for clinical therapies. This review discusses the current body of evidence for the existence of vascular wall progenitor cell subpopulations from development to adulthood and addresses the gains made and significant challenges that lie ahead in trying to accurately delineate their identities, origins, regulatory pathways, and relevance to normal vascular structure and function, as well as disease.

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“…Clonal analysis has revealed that adult mouse and human bone marrow-derived hematopoietic stem cells had potential of differentiation into functional endothelial cells in mice (Grant et al, 2002;Bailey et al, 2004;Cogle et al, 2004). Furthermore, transplanted vascular cells from adult thoracic aorta or inferior vena could contribute the generation of hematopoietic cells in lethally irradiated recipients (Montfort et al, 2002). These studies demonstrated that hemangioblasts persist into adult life while molecular identity and physiologic relevance of them in mouse and human bone marrow remain unclear.…”

Section: Adult Hemangioblasts In Mice and Humansmentioning

confidence: 99%

Molecular and developmental biology of the hemangioblast

Xiong

2008

Developmental Dynamics

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The hemangioblast hypothesis was proposed a century ago. The existence of hemangioblasts is now demonstrated in mouse and human embryonic stem cell (ESC) -derived embryoid bodies (EBs), in the mouse and zebrafish gastrula, and in adults. The hemangioblast is believed to derive from mesodermal cells, and is enriched in the Bry ؉ Flk1 ؉ and Flk1 ؉ Scl ؉ cell populations in EBs and in the posterior primitive streak of the mouse gastrula and in the ventral mesoderm of the zebrafish gastrula. However, recent studies suggest that the hemangioblast does not give rise to all endothelial and hematopoietic lineages in mouse and zebrafish embryos. Although several signaling pathways are known to involve the generation of hemangioblasts, it remains largely unknown how the hemangioblast is formed and what are the master genes controlling hemangioblast development. This review will summarize our current knowledge, challenges, and future directions on molecular and developmental aspects of the hemangioblast.

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Adult blood vessels restore host hematopoiesis following lethal irradiation

Cited by 38 publications

References 30 publications

Endothelial transplantation rejuvenates aged hematopoietic stem cell function

Endothelial transplantation rejuvenates aged hematopoietic stem cell function

Vascular Wall Progenitor Cells in Health and Disease

Molecular and developmental biology of the hemangioblast

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