Adult bacterial nasopharyngitis

Heald, Alison E.; Auckenthaler, Raymond; Borst, F.; Delaspre, Olga; Germann, D; Matter, L; Kaiser, Laurent; Stalder, Hans

doi:10.1007/bf02598283

Cited by 32 publications

(20 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11, 12, 31, 32 In support of our results, Han et al detected increased bacterial pathogens from nasal swabs obtained from symptomatic participants. 32 Similar findings have also been reported in a study of nasopharyngeal wall aspirates from adults with upper respiratory tract infection.…”

Section: Discussionsupporting

confidence: 91%

Detection of viral and bacterial pathogens in acute respiratory infections

Obasi

Barrett

Brown

et al. 2014

Journal of Infection

View full text Add to dashboard Cite

Objectives The role of bacteria in acute respiratory illnesses (ARI) of adults and interactions with viral infections is incompletely understood. This study tested the hypothesis that bacterial co-infection during ARI adds to airway inflammation and illness severity. Methods Two groups of 97 specimens each were randomly selected from multiplex-PCR identified virus-positive and virus-negative nasal specimens obtained from adults with new onset ARI, and 40 control specimens were collected from healthy adults. All specimens were analyzed for Haemophilus influenza(HI), Moraxella catarrhalis(MC) and Streptococcus pneumonia(SP) by quantitative-PCR. General linear models tested for relationships between respiratory pathogens, biomarkers (nasal wash neutrophils and CXCL8), and ARI-severity. Results Nasal specimens from adults with ARIs were more likely to contain bacteria (37% overall; HI=28%, MC=14%, SP=7%) compared to specimens from healthy adults (5% overall; HI=0%, MC=2.5%, SP=2.5%;p<0.001). Among ARI specimens, bacteria were more likely to be detected among virus-negative specimens compared to virus-positive specimens (46% vs. 27%;p=0.0046). The presence of bacteria was significantly associated with increased CXCL8 and neutrophils, but not increased symptoms. Conclusion Pathogenic bacteria were more often detected in virus-negative ARI, and also associated with increased inflammatory biomarkers. These findings suggest the possibility that bacteria may augment virus-induced ARI and contribute to airway inflammation. Summary We tested whether bacterial pathogens were associated with ARI illness and inflammation. Bacteria were detected more often in nasal secretions during ARI, especially in samples without detectable viruses, and were associated with increased airway inflammation, but not increased symptoms.

show abstract

Section: Discussionsupporting

confidence: 91%

Detection of viral and bacterial pathogens in acute respiratory infections

Obasi

Barrett

Brown

et al. 2014

Journal of Infection

View full text Add to dashboard Cite

show abstract

“…[16][17][18][19][20] This report illustrates for the first time the rare recovery of these organisms in patients in whom purulent nasal discharge did not develop. It also illustrates, for the first time, that the development to a purulent stage is associated with the pre-existing presence of these organisms in the NP of the patients.…”

Section: Discussionmentioning

confidence: 95%

Dynamics of nasopharyngitis in children

Brook

Gober

2000

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

show abstract

“…Heald et al 37 tried isolating the bacteria and virus from nasopharyngeal secretions of bacterial nasopharyngitis in 507 adults. After centrifuging these samples, the degree of leukocyte infiltration was then determined by microscopic observation, and the odds ratio was calculated in consideration of the relation between the leukocyte infiltration images and the detected bacteria.…”

Section: Discussionmentioning

confidence: 99%