Adult Atopic Dermatitis is Associated with Increased Aortic Stiffness

Szolnoky, Győző; Altmayer, Anita; Varga, József; Gavallér, Henriette; Kemény, Lajos; Forster, Tamás; Nemes, Attila

doi:10.1007/s40257-018-0344-y

Cited by 19 publications

(29 citation statements)

References 12 publications

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“…Chronic inflammation in psoriasis [35], inflammatory bowel disease [36], and rheumatoid arthritis [37] has been associated with altered aortic stiffness parameters. A recent study by Szolnoky et al [38] also found an increased aortic stiffness index in patients with AD compared to healthy volunteers. Aortic stiffness is considered as an essential marker that predicts CVD morbidity and mortality.…”

Section: Discussionmentioning

confidence: 80%

Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review

et al. 2018

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Atopic dermatitis (AD) may be associated with the metabolic syndrome and by that carry an increased risk of cardiovascular disease. Our objective was to provide an update on current knowledge of the association between AD and metabolic syndrome, including each component of the metabolic syndrome. A systematic literature review was performed to identify studies investigating the association between metabolic syndrome and AD from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A total of 14 studies, investigating the association between AD and the metabolic syndrome or AD and components of metabolic syndrome fulfilled the inclusion criteria and were included. It seems unlikely that the association between AD and metabolic syndrome is causal. However, women with AD tended to have components of metabolic syndrome more often than women without AD. There was a positive association between AD and central obesity measured as waist circumference, and this association was stronger for women than men. Despite conflicting results regarding hypertension, the association between hypertension and AD also appeared stronger for women. On the other hand, the association between AD and hyperglycemia appears unlikely, and the association between AD and cholesterol levels was inconsistent. In conclusion, it remains unclear whether AD is a risk factor for metabolic syndrome and its components. However, data indicate that central obesity is associated with AD and that the association is stronger for women than men.

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Section: Discussionmentioning

confidence: 80%

Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review

et al. 2018

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“…Interestingly, national data have suggested hypertension rates of 32.4% in women of any BMI aged 40 to 59 years and even higher hypertension rates (up to 60%) in Caucasian women with obesity and a mean age of 63 . Nonetheless, patients with lipedema were shown to develop aortic stiffness in one study , which seems to contradict these findings. Geographic differences of women included in the these studies may partly explain such apparently contradictory findings.…”

Section: Clinical Presentation and Cardiovascular Riskmentioning

confidence: 95%

“…Williams syndrome, a genetic disease presenting with lipedema phenotype in both males and females, among other clinical features, is associated with loss of several genes, including ELN for elastin, which is an important component of connective tissue . Coherently with the hypothesis of an etiological role for loss of elasticity in lipedema, aortic stiffness develops in this condition as well as in Williams syndrome . Research on both humans and animal models has suggested possible involvement of other genes.…”

Section: Pathophysiologymentioning

confidence: 99%

Lipedema: A Call to Action!

Buso

Depairon

Tomson

et al. 2019

Obesity

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Lipedema is a chronic progressive disease characterized by abnormal fat distribution resulting in disproportionate, painful limbs. It almost exclusively affects women, leading to considerable disability, daily functioning impairment, and psychosocial distress. Literature shows both scarce and conflicting data regarding its prevalence. Lipedema has been considered a rare entity by several authors, though it may be a far more frequent condition than thought. Despite the clinical impact on women's health, lipedema is in fact mostly unknown, underdiagnosed, and too often misdiagnosed with other similarly presenting diseases. Polygenic susceptibility combined with hormonal, microvascular, and lymphatic disorders may be partly responsible for its development. Furthermore, consistent information on lipedema pathophysiology is still lacking, and an etiological treatment is not yet available. Weight loss measures exhibit minimal effect on the abnormal body fat distribution, resulting in eating disorders, increased obesity risk, depression, and other psychological complaints. Surgical techniques, such as liposuction and excisional lipectomy, represent therapeutic options in selected cases. This review aims to outline current evidence regarding lipedema epidemiology, pathophysiology, clinical presentation, differential diagnosis, and management. Increased awareness and a better understanding of its clinical presentation and pathophysiology are warranted to enable clinicians to diagnose and treat affected patients at an earlier stage.

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“…Lipedema is characterized by cuffing sign (fat deposition spares feet), non‐pitting oedema, easy bruising and pain and often remains refractory to various dietary restrictions 1 . From the cardiological point of view lipedema is known to be associated with higher aortic stiffness 5 and a recent clinical study showed a high incidence of altered left ventricular (LV) standard two‐dimensional (2D) echocardiographic parameters (significantly larger dimensions, end‐diastolic and end‐systolic volumes, transmitral flow velocity) and also LV rotational changes (significantly lower LV apical rotation and twist) detected by three‐dimensional speckle‐tracking echocardiography (3DSTE) 6 . Normally, opposite rotations of the LV apex and base result in LV twisting motion which supports ejection during systole 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Increased preload and high vascular resistance with stiffer arteries result in elevated afterload 8 . In lipedema obesity is not a prerequisite for the development of high aortic stiffness, however, bulky limbs with robust fat deposition may account for arterial resistance 5 …”

Section: Introductionmentioning

confidence: 99%

The impact of lower body compression garment on left ventricular rotational mechanics in patients with lipedema—Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study

et al. 2020

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Summary Lipedema is a lymphedema‐masquerading symmetrical, bilateral and disproportional obesity. Its conservative maintenance treatment comprises the use of flat‐knitted compression pantyhoses. Lipedema is known to be associated with left ventricular morphological and functional alterations. The present study aimed to assess the effects of graduated compression stockings on left ventricular (LV) rotational mechanics measured by three‐dimensional speckle‐tracking echocardiography (3DSTE) in lipedema patients. The present study comprised twenty lipedema patients (mean age: 45.8 ± 11.0 years, all females) undergoing 3DSTE who were also compared to 51 age‐ and gender‐matched healthy controls (mean age: 39.8 ± 14.1 years, all females). 3DSTE analysis was performed at rest, and subsequent to 1 hour application of compression class 2 made‐to‐measure flat‐knitted pantyhose. Six lipedema patients showed significant LV rotational abnormalities. Of the remaining fourteen lipedema patients LV basal rotation rotation showed significant reduction, while LV apical rotation showed significant increase with unchanged LV twist after a 60‐minute use of compression garment. Significant changes in LV rotational mechanics could be detected among 14 women with lipedema after the use of compression garment however six probands have special LV rotational abnormalities at baseline and/or after compression.

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Adult Atopic Dermatitis is Associated with Increased Aortic Stiffness

Cited by 19 publications

References 12 publications

Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review

Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review

Lipedema: A Call to Action!

The impact of lower body compression garment on left ventricular rotational mechanics in patients with lipedema—Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study

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