Adult alveolar rhabdomyosarcoma on extremity, successful treatment with radiotherapy following chemotherapy: Serial case report

Widikusumo, Arundito; Triyanto, Lopo; Istutiningrum, Rochmawati; Purnamawati, Schandra

doi:10.4103/ijabmr.ijabmr_100_18

Cited by 3 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If the tumor is too large to have negative surgical margins, chemotherapy is administered because larger tumors have a higher incidence of metastasis in ARMS. 10 Multimodal therapy in line with the pediatric RMS treatment guidelines yielded better survival and local control. 11 It was seen that when surgery and radiation therapy were combined with chemotherapy, using doxorubicin, ifosfamide, and vincristine resulted in 55% overall and 64% disease-free survival in 2 years.…”

Section: Discussionmentioning

confidence: 97%

Rare Adult Subtype of Rhabdomyosarcoma, a Common Childhood Soft Tissue Carcinoma

Dondapati

Reyes

Ahmad

et al. 2021

Journal of Investigative Medicine High Impact Case Reports

View full text Add to dashboard Cite

Rhabdomyosarcoma is a malignant soft tissue sarcoma of primitive mesenchymal cells, showing varying degrees of striated skeletal muscle cell differentiation. It is a very common cancer of childhood and adolescence, but rarely seen in the adult population. Here, we present a case of a 33-year-old male presented with a poorly differentiated desmin positive alveolar rhabdomyosarcoma in the left arm. The prognosis of alveolar rhabdomyosarcoma in adults is very poor, frequently detected at advanced stages or with metastases. The alveolar subtype in particular has been found to have a more aggressive course with a high rate of metastasis. Recent studies have shown that using pediatric treatment guidelines resulted in better survival outcomes and local control, but the survival rates are still below that of the pediatric population. Newer studies are looking into using specific molecular markers for more targeted therapy in hopes of further improving survival rates in the adult population.

show abstract

Section: Discussionmentioning

confidence: 97%

Rare Adult Subtype of Rhabdomyosarcoma, a Common Childhood Soft Tissue Carcinoma

Dondapati

Reyes

Ahmad

et al. 2021

Journal of Investigative Medicine High Impact Case Reports

View full text Add to dashboard Cite

show abstract

“…In our patients, tumor subtype significantly and independently predicted the survival of patients with metastatic LRMS. Surgery, radiotherapy, and chemotherapy are still the three cornerstones of treatment for RMS (26). Complete surgical excision is seen as the mainstay of therapy for RMS (1,23).…”

Section: Discussionmentioning

confidence: 99%

“…Surgery, radiotherapy, and chemotherapy are still the three cornerstones of treatment for RMS ( 26 ). Complete surgical excision is seen as the mainstay of therapy for RMS ( 1 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, our results demonstrated that surgery for the primary disease was not associated with survival in patients with metastatic LRMS. Radiotherapy was frequently delivered in localized LRMS and approved to be a positive independent survival predictor ( 23 , 26 ), which also improved survival significantly in those patients with metastatic LRMS. However, radiotherapy might increase metastatic potential in the preclinical model of metastatic behavior of rhabdomyosarcoma xenografts ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis

et al. 2021

View full text Add to dashboard Cite

Purpose: Given the poor prognosis and the relative rarity of patients diagnosed with limb rhabdomyosarcoma (LRMS) and metastasis at diagnosis, we performed this study to reveal distinctive clinical features and evaluated prognostic factors of this special population in order to provide appropriate treatment.Patients and Methods: We carried out retrospective research of patients diagnosed with LRMS and metastasis from 1975 to 2016 using the Surveillance, Epidemiology, and End Results (SEER) program database. Survival curves were generated by applying the Kaplan–Meier method. In terms of evaluating and determining independent predictors of survival, we conducted univariate and multivariate survival analyses using the Cox proportional hazard regression model.Results: This retrospective analysis contained a series of 245 patients with metastatic LRMS, with male predominance (male vs. female, 1.6:1). Nearly half of the patients were diagnosed with alveolar rhabdomyosarcoma (44.9%). According to the results of the univariate and multivariate analyses, younger age, tumor subtype, and radiotherapy were found to be significantly associated with improved overall survival (OS) and cause-specific survival (CSS).Conclusions: Patients with LRMS and metastasis at diagnosis experienced a quite poor prognosis. Age at diagnosis, tumor subtype, and radiotherapy can help clinicians to better estimate the prognosis. This study indicated that local radiotherapy can provide a survival benefit.

show abstract

“…In literature, there is a paucity of successful reports of neoadjuvant chemotherapy and adjuvant radiotherapy for adult RMS. 17,18 From 1989 to 2009, Wang et al published a case series of 25 adult soft tissue prostate tumors (six were RMS) demonstrating that chemotherapy did not improve overall survival. 19 Given our findings, it is plausible that specific subtypes of soft tissue tumors in the prostate, like RMS, may be responsive to chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and survival outcome of adult kidney, bladder, and prostate rhabdomyosarcoma: A SEER database analysis

Patel

Hensel

et al. 2020

Rare Tumors

View full text Add to dashboard Cite

Rhabdomyosarcoma (RMS) is rare in adulthood, accounting for 2%–5% of adult soft tissue tumors, and less than 20% occur in genitourinary organs. Given its rarity, survival data on adult kidney, bladder, and prostate RMSs is limited. In this population-based analysis, we performed an analysis of all adult RMS cases reported in Surveillance, Epidemiology, and End Results (SEER) database to understand prognostic factors among kidney, bladder, and prostate RMS. A query of the SEER database was performed from 1973 to 2016 for patients >18 of age with RMS. The final cohort consisted of 14 kidney, 35 bladder, and 21 prostate RMS cases in the adult population. Demographic, treatment, and survival data were obtained. Analysis was performed using Fisher’s exact test, survival analysis, and model. The median (range) age of diagnosis for adult bladder RMS was 65 years old (19–84) compared to 52.5 (28–68) and 42 (19–87) for kidney and prostate ( p = 0.007). About 78.6% of patients underwent surgical intervention. Five-year overall survival (OS) for adult kidney, bladder, and prostate RMS are 17.1% (2.9–41.6%), 22.2% (9.4–38.4%), and 33.0 (12.8–55.0%), respectively. OS was not statistically associated with primary site ( p = 0.209). On multivariable analysis, compared to adult bladder RMS, kidney RMS had a higher incidence of mortality (HR: 2.16, 95% CI 1.03–4.53, p = 0.041). Incidence of mortality from prostate RMS was not significantly different from bladder RMS (HR: 0.70, 95% CI 0.30–1.65, p = 0.411). Extent of disease (HR: 5.17, 95% CI 2.09–12.79, p < 0.001) and older age (HR 1.03, 95% CI 1.01–1.04, p = 0.002) were adverse prognostic factors for OS. Overall survival at 5 years for adult kidney, bladder, and prostate RMS is poor. Localized disease and younger age are prognostic factors for improved outcomes in adult RMS. Hence, early diagnosis and intervention appear paramount to improved survival for this rare malignancy in adulthood.

show abstract

Adult alveolar rhabdomyosarcoma on extremity, successful treatment with radiotherapy following chemotherapy: Serial case report

Cited by 3 publications

References 9 publications

Rare Adult Subtype of Rhabdomyosarcoma, a Common Childhood Soft Tissue Carcinoma

Rare Adult Subtype of Rhabdomyosarcoma, a Common Childhood Soft Tissue Carcinoma

Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis

Epidemiology and survival outcome of adult kidney, bladder, and prostate rhabdomyosarcoma: A SEER database analysis

Contact Info

Product

Resources

About