2008
DOI: 10.1007/s11094-008-0144-4
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Adsorptive Stripping Voltammetric Determination of Irbesartan in Bulk and Pharmaceutical Products

Abstract: Adsorptive stripping Voltammetric determination of irbesartan using a hanging mercury drop electrode (HMDE) is described. The method is based on adsorptive accumulation of the species at the HMDE, followed by a first-harmonic alternating current (AC) stripping sweep at pH 6. The behavior of the adsorptive stripping response was studied under various experimental conditions, e.g., type of supporting electrolyte, pH, accumulation time, scan rate, and mode of sweep. In Britton-Robinson buffer solution, a quasi-re… Show more

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Cited by 15 publications
(15 citation statements)
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“…The studied drugs have common biphenyl tetrazole nucleus [12,13]; as a result, they have the same spectral characters so these methods have no sufficient selectivity and cannot distinguish between them. Several electrochemical methods were reported for their quantification [14][15][16][17]. Different separation techniques such as electrophoresis [18][19] and high-performance liquid chromatography (HPLC) [20][21][22][23][24] were reported for the separation and determination of several members of the studied drugs.…”
Section: Introductionmentioning
confidence: 99%
“…The studied drugs have common biphenyl tetrazole nucleus [12,13]; as a result, they have the same spectral characters so these methods have no sufficient selectivity and cannot distinguish between them. Several electrochemical methods were reported for their quantification [14][15][16][17]. Different separation techniques such as electrophoresis [18][19] and high-performance liquid chromatography (HPLC) [20][21][22][23][24] were reported for the separation and determination of several members of the studied drugs.…”
Section: Introductionmentioning
confidence: 99%
“…Capillary electrophoresis using different buffer solutions and constant voltage at 20 KV with UV detection was reported [11,12]. Voltammetric methods [13,14] and spectrophotometric methods [15][16][17][18][19][20] were extensively used for analysis of the cited sartans.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, in most of the reported HPLC methods for routine clinical analysis, a high-throughput analysis with expensive solid-phase extraction [8][9][10][11] is always not advantageous as such equipment and techniques are not available in most of the laboratories. Moreover, the two reported voltammetric methods 20,21 did not offer a sufficient sensitive quantification limit of irbesartan especially in pharmacokinetic studies. The first method 20 has been described for determination of irbesartan in formulation using differential-pulse and squarewave voltammetric techniques at hanging mercury dropping electrode (HMDE) and in spiked human serum using squarewave voltammetric technique (LOD = 6.14×10 -6 mol L -1 (2.63 µg mL -1 )) but not in real plasma samples.…”
mentioning
confidence: 98%
“…These include high performance liquid chromatography (HPLC), [4][5][6][7][8][9][10] high-performance thinlayer chromatography (HPTLC), 11 liquid chromatographymass spectrometry (LC-MS), 12 spectrophotometry, [13][14][15][16][17][18] capillary electrophoresis 19 and voltammetry. 20,21 Almost all the reported methods have some drawbacks, lack in some validation parameters and necessitate time-consuming liquidliquid extraction steps prior to the analysis. On the other hand, in most of the reported HPLC methods for routine clinical analysis, a high-throughput analysis with expensive solid-phase extraction [8][9][10][11] is always not advantageous as such equipment and techniques are not available in most of the laboratories.…”
mentioning
confidence: 99%