Adsorptive stripping voltammetric determination of dicyclomine hydrochloride at a glassy carbon electrode modified with silver decorated Fe<sub>3</sub>O<sub>4</sub>nanocubes in pharmaceutical and biological samples

Rawool, Chaitali R.; Rajpurohit, Anuja S.; Punde, Ninad S.; Srivastava, Ashwini K.

doi:10.1039/c8ay00009c

Cited by 10 publications

(3 citation statements)

References 40 publications

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“…S4 that E pa values gradually shifted towards more positive potential values with the increase of scan rates, which confirm the irreversible nature of the electrochemical reaction of ALN at 1T-MoS 2 /NF/SPE. 45 This irreversibility facilitates to calculate the number of electron transferred in the electrochemical reaction of ALN by Laviron theory 46 and the corresponding equation is given below:…”

Section: Resultsmentioning

confidence: 99%

An Electrochemical Nanosensor Using a Screen-Printed Electrode Modified with 1T-MoS₂/Nafion for Determination of Renin Inhibitor Aliskiren

Erk

2021

J. Electrochem. Soc.

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An overdose of the antihypertensive agent in the human body causes a high cardiotoxicity, which may lead to the heart failure and stroke. The routine detection of amount of the antihypertensive agents in biological fluids is vital to control the regulation of blood pressure. In this work, a novel and sensitive electrochemical sensor based on nafion (NF) modified molybdenum disulfide in a metallic 1T phase (1T-MoS2) for voltammetric determination of renin-inhibitor Aliskiren (ALN) in human plasma. 1T-MoS2 was effectively synthesized by the exfoliation of bulk MoS2 using NaK alloy. The structure and morphology of 1T-MoS2 was characterized by Raman, XPS and TEM. The electrochemical behavior of ALN was investigated on a screen-printed electrode (SPE) modified with 1T-MoS2/NF nanocomposite by cyclic voltammetry (CV) and adsorptive stripping differential pulse voltammetry (AdsDPV). The proposed electrochemical sensing platform (1T-MoS2/NF/SPE) demonstrated a good electrochemical activity towards the ALN. Under optimized condition, 1T-MoS2/NF/SPE exhibited an outstanding analytical performance for ALN with a wide linear working range of 0.05–7.0 μM and a low limit of detection (LOD) of 8.0 nM. The reliability of the developed sensing platform was successfully tested by analyzing of ALN in human plasma samples with satisfactory recoveries. Therefore, 1T-MoS2/NF/SPE could present as a promising analytical tool for the determination of ALN at trace level in clinical samples.

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Section: Resultsmentioning

confidence: 99%

An Electrochemical Nanosensor Using a Screen-Printed Electrode Modified with 1T-MoS₂/Nafion for Determination of Renin Inhibitor Aliskiren

Erk

2021

J. Electrochem. Soc.

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“…Literature review reveals that methods have been reported for analysis of dicyclomine hydrochloride in bulk and pharmaceutical formulation by UV spectrophotometry [12], colorimetry [13] and voltammetry [14] either alone or in combination with other drugs. Quantification of dicyclomine hydrochloride in blend with other drugs using UV spectroscopy [15], TLC [16] and LC [17,18] was also reported.…”

Section: Discussionmentioning

confidence: 99%

Development of methods for the study of dicyclomine hydrochloride in combination with paracetamol as an object of forensic-pharmaceutical examination

Бевз

Sych²,

Fedosov

et al. 2022

SR: PS

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The aim. Selection and development of methods for the tasks of forensic pharmaceutical examination as case materials suspected of falsification or non-medical use of dicyclomine hydrochloride in combination with paracetamol in the form of tablets. Materials and methods. The study presents the developed methods of detection and identification of dicyclomine by TLC, IR spectroscopy and GC-MS, which were performed using reagents that meet the EP, USP and USPU requirements, Class A glassware and qualified devices. Identification by IR spectroscopy was performed in the range from 500 to 4000 cm-1 on the device “Nicolet 380 FT-IR Spectrometer by Thermo Fisher Scientific”. TLC was performed on Sorbfil plates for TLC-PET-H-UV and Sorbfil plates for TLC-AF-UV (CJSC “Sorbpolymer”, Russia). The following systems were used as mobile phases: dioxane-chloroform-acetone-25 % ammonia solution (47.5:45:5:2.5); toluene-acetone-ethanol-25 % ammonia solution (45:45:7.5:2.5); ethyl acetate-methanol-25 % ammonia solution (17:2:1)). The resulting chromatographic zones were detected by irradiation with UV light and further treatment with color reagents (30 % iron (III) chloride solution; Dragendorff's reagent modified by Munier; Marquis reagent; Froehde reagent; Mandelin reagent; FPN reagent). Analysis by gas chromatography with mass detection was performed using a gas chromatograph with a mass spectrometric detector GCMS-QP2020. Data were analyzed using the program: GCMSsolution, LabSolutions Insight (Shimadzu Corporation, Tokyo, Japan). Results. For the first time, the conditions for the extraction of dicyclomine hydrochloride from aqueous solutions were studied and the optimal conditions for their isolation as an object of forensic pharmaceutical examination is defined. The method of detection of dicyclomine hydrochloride and paracetamol in the drug “Trigan-D” by the methods of thin-layer chromatography, gas-liquid chromatography and chromato-mass spectrometry was developed, and the detection limits of the substances under study were determined. Conclusion. The developed methods for dicyclomine hydrochloride in the form of tablets with paracetamol meet the requirements of the current legislation of Ukraine and the Ministry of Justice of Ukraine. The data obtained prove the high sensitivity and reproducibility of the methods and prove the possibility of their introduction into the practice of forensic pharmaceutical examination

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“…Manufacturing corporations need both qualitative including quantitative studies to guarantee that its raw materials fulfil the requisites and that the finished material is of high quality. DEH quantification in tablet formulation (by UV spectrophotometry, colorimetry and voltammetry) [10][11][12] and in milk, serum and urine (by potentiometry and voltammetry) [12,13] was described. DEC quantification in capsule and tablet formulations (by HPLC and infrared spectroscopy) [14,15] was published.…”

Section: Introductionmentioning

confidence: 99%

A new stability-indicating RP-HPLC method for the determination of dicyclomine hydrochloride and dimethicone combination in tablet dosage forms

et al. 2021

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Background We describe a “stability-indicating liquid chromatography” technique for the estimation of dimethicone (DEC) and dicyclomine hydrochloride (DEH) in the established tablet formulations. Individual quantification of DEH and DEC was reported. But simultaneous quantification of DEH and DEC was lacking. DEH and DEC were analysed on an “XTerra C18 column (250 mm × 4.6 mm, 5 μm)” with the mobile phase solvent run isocratically with 0.1M K2HPO4-acetonitrile (55:45, v/v) on a flow speed of 1.0 mL/min. Results The chromatographic run period for the DEC and DEH assay was 6.0 min with retention times of 2.134 and 2.865 min, respectively. The method was validated for accuracy (99.453 to 100.417% and 99.703 to 100.303% recovery values for DEH and DEC, respectively), precision (RSV value 0.135% for DEC and 0.171% for DEH), linearity (5–15 μg/mL for DEH and 20–60 μg/mL for DEC), selectivity (no hinderance from excipients) and specificity (no hinderance from degradants) recovery. Conclusion The developed stability-indicating liquid chromatography process was well applied to established tablet formulations.

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Adsorptive stripping voltammetric determination of dicyclomine hydrochloride at a glassy carbon electrode modified with silver decorated Fe₃O₄nanocubes in pharmaceutical and biological samples

Abstract: Synthesis process of Fe3O4/Ag nanocomposite followed by its fabrication as an electrochemical sensor for determination of DcCl using adsorptive stripping square wave voltammetry.

Cited by 10 publications

References 40 publications

An Electrochemical Nanosensor Using a Screen-Printed Electrode Modified with 1T-MoS₂/Nafion for Determination of Renin Inhibitor Aliskiren

An Electrochemical Nanosensor Using a Screen-Printed Electrode Modified with 1T-MoS₂/Nafion for Determination of Renin Inhibitor Aliskiren

Development of methods for the study of dicyclomine hydrochloride in combination with paracetamol as an object of forensic-pharmaceutical examination

A new stability-indicating RP-HPLC method for the determination of dicyclomine hydrochloride and dimethicone combination in tablet dosage forms

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Adsorptive stripping voltammetric determination of dicyclomine hydrochloride at a glassy carbon electrode modified with silver decorated Fe3O4nanocubes in pharmaceutical and biological samples

Abstract: Synthesis process of Fe3O4/Ag nanocomposite followed by its fabrication as an electrochemical sensor for determination of DcCl using adsorptive stripping square wave voltammetry.

Cited by 10 publications

References 40 publications

An Electrochemical Nanosensor Using a Screen-Printed Electrode Modified with 1T-MoS2/Nafion for Determination of Renin Inhibitor Aliskiren

An Electrochemical Nanosensor Using a Screen-Printed Electrode Modified with 1T-MoS2/Nafion for Determination of Renin Inhibitor Aliskiren

Development of methods for the study of dicyclomine hydrochloride in combination with paracetamol as an object of forensic-pharmaceutical examination

A new stability-indicating RP-HPLC method for the determination of dicyclomine hydrochloride and dimethicone combination in tablet dosage forms

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Adsorptive stripping voltammetric determination of dicyclomine hydrochloride at a glassy carbon electrode modified with silver decorated Fe₃O₄nanocubes in pharmaceutical and biological samples

An Electrochemical Nanosensor Using a Screen-Printed Electrode Modified with 1T-MoS₂/Nafion for Determination of Renin Inhibitor Aliskiren

An Electrochemical Nanosensor Using a Screen-Printed Electrode Modified with 1T-MoS₂/Nafion for Determination of Renin Inhibitor Aliskiren