Adsorption of Thymol onto Natural Clays of Morocco: Kinetic and Isotherm Studies

Ziyat, Hamid; Bennani, Mohammed Naciri; Hajjaj, Hassan; Qabaqous, Omar; Arhzaf, Said; Mekdad, Soumiya; Allaoui, Safae

doi:10.1155/2020/4926809

Cited by 7 publications

(5 citation statements)

References 33 publications

(40 reference statements)

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“…Curcumin and ibuprofen solutions were analyzed by UV-2550 UV-VIS (Shimadzu Joshi Co., Kyoto, Japan) spectrophotometer at wavelengths of 425 nm and 264 nm, respectively. The adsorption amount of curcumin and ibuprofen (mg/g) was calculated using the following equation [81]:…”

Section: Molecular Dockingmentioning

confidence: 99%

The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol

Li,

Luo,

et al. 2024

Molecules

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Porous materials are widely used as an effective strategy for the solubilization of insoluble drugs. In order to improve the solubility and bioavailability of low water-solubility drugs, it is necessary to prepare porous materials. Mannitol is one of the most popular excipients in food and drug formulations. In this study, porous mannitol was investigated as a drug carrier for low water solubility drugs. Its fabrication, drug loading, and drug release mechanisms were investigated. Porous mannitol was fabricated using the co-spray–antisolvent process and utilizing polyvinylpyrrolidone K30 (PVP K30) as the template agent. Porous mannitol particles were prepared by changing the proportion of the template agent, spraying the particles with mannitol, and eluting with ethanol in order to regulate their pore structure. In subsequent studies, porous mannitol morphology and characteristics were determined systematically. Furthermore, curcumin and ibuprofen, two poorly water-soluble drugs, were loaded into porous mannitol, and their release profiles were analyzed. The results of the study indicated that porous mannitol can be prepared using PVP K30 as a template and that the amount of template agent can be adjusted in order to control the structure of the porous mannitol. When the template agent was added in amounts of 1%, 3%, and 5%, the mannitol pore size increased by 167.80%, 95.16%, and 163.98%, respectively, compared to raw mannitol. Molecular docking revealed that mannitol and drugs are adsorbents and adhere to each other by force interaction. The cumulative dissolution of curcumin and ibuprofen-loaded porous mannitol reached 69% and 70%, respectively. The release mechanism of curcumin and ibuprofen from drug-loaded mannitol was suitable for the Korsmeyer–Peppas kinetic model. In summary, the co-spray–antisolvent method proved effective in fabricating porous materials rapidly, and porous mannitol had a remarkable effect on drug solubilization. The results obtained are conducive to the development of porous materials.

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Section: Molecular Dockingmentioning

confidence: 99%

The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol

Li,

Luo,

et al. 2024

Molecules

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“…This procedure ensures the intercalation of CTA + species inside the interlayer space of the clay, replacing Na + ions [35]. Moreover, the presence of CTA + species in the saponite allows for increasing both (i) the interlamellar distance and (ii) the hydrophobicity of the clay in such a way as to increase its affinity with the uncharged nonpolar aldehydes and, thus, potentially increasing the concentration of organic molecules incorporated in the inorganic host during the impregnation [54][55][56][57][58][59][60].…”

Section: Cta-intercalated Synthetic Saponite Clays Impregnated With S...mentioning

confidence: 99%

Impregnation of Synthetic Saponites with Aldehydes: A Green Approach in the Intercalation of Bioactive Principles

et al. 2022

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Synthetic saponite clay was impregnated with either linear saturated or unsaturated aldehydes through an incipient-wetness deposition approach. To increase the aldehyde loading, saponite was also intercalated with positively charged cetyltrimethylammonium (CTA+) species, aiming to expand the clay gallery and to increase the hydrophobic character of the host solid. A multitechnique, physicochemical investigation was performed on the organic–inorganic hybrid solids. The analyses revealed that the aldehydes are mainly adsorbed on the clay particles’ surface, with a small fraction inside the interlayer space. In CTA+-modified saponites, the concentration of saturated aldehydes was higher than the one observed in the pure clay. These features are quite promising for the development of novel layered solids containing bioactive molecules for ecocompatible and economically sustainable applications, especially in agriculture, for the development of innovative hybrid materials for crop protection.

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“…TYM was immobilized by Ziyat et al [113] onto purified Moroccan clay "Rhassoul" and the organically modified one. It was estimated that the adsorption capacities were of 6 mg/g and 16 mg/g for purified Rhassoul and modified one, respectively.…”

Section: Bio-derived Agrochemicalsmentioning

confidence: 99%

New Trends in Clay-Based Nanohybrid Applications: Essential Oil Encapsulation Strategies to Improve Their Biological Activity

Saad¹,

Ayed²,

Srasra³

et al. 2022

Nanoclay - Recent Advances, New Perspectives and Applications

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Essential oils (EOs) are used in medicinal, pharmaceutical, cosmetic, agricultural, and food industries thanks to their key properties and multiple benefits. Several techniques and embedding materials are used to nanoencapsulate EOs, in order to keep them from environmental conditions and boost their bioefficiency by controlled release. In recent years, the interest for clay nanoparticles as nanoencapsulation materials for EOs is increasing owing to their abundance in nature, low cost, inertness, and special structure. Thus, this chapter focuses on highlighting data and contributions dealing with EOs incorporation into nanoclay particles, their current applications and nanohybrid formation benefits on the stability, bioavailability, and sustained release of EOs. An overview about nanoclays used for EOs nanoencapsulation is highlighted in the beginning of this chapter followed by a brief description of EOs’ chemical composition and properties.

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Adsorption of Thymol onto Natural Clays of Morocco: Kinetic and Isotherm Studies

Cited by 7 publications

References 33 publications

The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol

The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol

Impregnation of Synthetic Saponites with Aldehydes: A Green Approach in the Intercalation of Bioactive Principles

New Trends in Clay-Based Nanohybrid Applications: Essential Oil Encapsulation Strategies to Improve Their Biological Activity

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