Adsorption of the Pt^II Anticancer Drug Carboplatin by Mesoporous Silica

Abstract

MCM-41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM-41 adsorbs the front-line anticancer drug carboplatin, [Pt(CBDCA-O,O')(NH3)2] (CBDCA=cyclobutane-1,1-dicarboxylate; 1), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM-41 adsorbs 1.8+/-0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 mM drug in H2O. The pseudo-first-order rate constant for adsorption of carboplatin by MCM-41, measured using [1H,15N] heteronuclear single quantum coherence (HSQC) NMR, and 15N-labeled carboplatin is k(1)=2.92+/-2.17 x 10(-6) s(-1) at ca. 25 degrees.

Neutron-Activatable Holmium-Containing Mesoporous Silica Nanoparticles as a Potential Radionuclide Therapeutic Agent for Ovarian Cancer

“…This approach is common for incorporating small molecules into MSNs (13)(14)(15). On the basis of TEM images, these nanoparticles were estimated to be approximately 80-100 nm in diameter, and they had a z-potential in water of 249.2 6 6.0 mV.…”

“…These include a high surface area, tunable pore structures, and physicochemical stability. The silica nanostructure is capable of adsorbing small molecules such as ibuprofen, acetylsalicylic acid, and famotidine, as well as the anticancer drugs camptothecin and carboplatin (13)(14)(15). The cytotoxicity and biocompatibility of mesoporous silica have previously been examined (16)(17)(18).…”

Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery

“…Di Pasqua et al reported using neutron-activatable Holmium-containing MSNs for radiotherapy. The anticancer drug carboplatin-loaded mesoporous silica was also used as a radiosensitizer [18,19]. The mesoporous silica DAM-1 (Dallas Amorphous Material-1) templated by Vitamin E-TPGS (α-tocopheryl polyethylene glycol 1000 succinate) was used to deliver hydrophobic drugs [20].…”

MCM-41 mesoporous silica anoparticles and their adsorption for targeting drug delivery systems

“…1 MỞ ĐẦUano silica cấu trúc xốp (Mesoporous Silica Nanoparticles, MSNs) là vật liệu đã thu hút được sự quan tâm nghiên cứu của các nhà khoa học nhằm ứng dụng làm hệ phân phối thuốc chống ung thư nhờ những tính chất nổi trội của nó như có tính ổn định, tương thích sinh học, cấu trúc xốp, diện tích bề mặt lớn nên có khả năng chứa nhiều dược liệu, …[1,2,4]. Trong đó, MCM-41 với cấu…”