Adsorption of the cis-[Pt(NH3)2(P2O7)]2− (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues

Benedetti, Michele; Castro, Federica De; Romano, Alessandro; Migoni, Danilo; Piccinni, Barbara; Verri, Tiziano; Lelli, Marco; Roveri, Norberto; Fanizzi, Francesco Paolo

doi:10.1016/j.jinorgbio.2016.01.019

Cited by 19 publications

(17 citation statements)

References 40 publications

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“…HA, in particular, has been frequently used in several studies to stabilize, protect, and deliver molecules or radionuclides. [14][15][16][17][18][19][20][21][22] HA represents the major components of bone, tooth, and cartilaginous tissues. It possesses several properties such as biocompatibility, biomimetic dimensions, osteoconductivity, and degradability, which make it suitable for several applications 16,23 when combined with different biological molecules.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages

Fulgione

Ianniello

Papaianni

et al. 2019

IJN

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The use of bacteriophages represents a valid alternative to conventional antimicrobial treatments, overcoming the widespread bacterial antibiotic resistance phenomenon. In this work, we evaluated whether biomimetic hydroxyapatite (HA) nanocrystals are able to enhance some properties of bacteriophages. The final goal of this study was to demonstrate that biomimetic HA nanocrystals can be used for bacteriophage delivery in the context of bacterial infections, and contribute-at the same time-to enhance some of the biological properties of the same bacteriophages such as stability, preservation, antimicrobial activity, and so on. Materials and methods: Phage isolation and characterization were carried out by using Mitomycin C and following double-layer agar technique. The biomimetic HA water suspension was synthesized in order to obtain nanocrystals with plate-like morphology and nanometric dimensions. The interaction of phages with the HA was investigated by dynamic light scattering and Zeta potential analyses. The cytotoxicity and intracellular killing activities of the phage-HA complex were evaluated in human hepatocellular carcinoma HepG2 cells. The bacterial inhibition capacity of the complex was assessed on chicken minced meat samples infected with Salmonella Rissen. Results: Our data highlighted that the biomimetic HA nanocrystal-bacteriophage complex was more stable and more effective than phages alone in all tested experimental conditions. Conclusion: Our results evidenced the important contribution of biomimetic HA nanocrystals: they act as an excellent carrier for bacteriophage delivery and enhance its biological characteristics. This study confirmed the significant role of the mineral HA when it is complexed with biological entities like bacteriophages, as it has been shown for molecules such as lactoferrin.

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Section: Introductionmentioning

confidence: 99%

Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages

Fulgione

Ianniello

Papaianni

et al. 2019

IJN

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“…Other groups have investigated biomimetic hydroxyapatite nanocrystals as the delivery vehicles for platinum (II) [104][105][106]. The advantage of hydroxyapatite nanostructures is their intrinsic biocompatibility with biological systems since they are mineral constituents of bone [107].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nano-Based Systems and Biomacromolecules as Carriers for Metallodrugs in Anticancer Therapy

2018

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Since the discovery of cisplatin and its potency in anticancer therapy, the development of metallodrugs has been an active area of research. The large choice of transition metals, oxidation states, coordinating ligands, and different geometries, allows for the design of metal-based agents with unique mechanisms of action. Many metallodrugs, such as titanium, ruthenium, gallium, tin, gold, and copper-based complexes have been found to have anticancer activities. However, biological application of these agents necessitates aqueous solubility and low systemic toxicity. This minireview highlights the emerging strategies to facilitate the in vivo application of metallodrugs, aimed at enhancing their solubility and bioavailability, as well as improving their delivery to tumor tissues. The focus is on encapsulating the metal-based complexes into nanocarriers or coupling to biomacromolecules, generating efficacious anticancer therapies. The delivery systems for complexes of platinum, ruthenium, copper, and iron are discussed with most recent examples. explored as possible alternatives, but none have yet entered the clinic. Importantly, high efficacy of platinum paved the way for the development of other transition metal complexes, many with outstanding cytotoxic properties against cancer cells.Transition metals form complexes of multiple geometries based on the number of coordination sites, offering a stereoisomeric diversity higher than carbon. In addition, a synthesis of metallodrugs requires fewer steps when compared to organic compounds. This is accompanied by a myriad choice of coordinating ligands [17] facilitating fine-tuning the properties of metal-based complexes [17,18]. The octahedral titanium species cis-diethoxy-bis(1-phenylbutane-1,3-dionato)titanium(IV) [(bzac) 2 Ti(OEt) 2 ] (budotitane), was the first non-Pt(II) metal compound that reached clinical trials [19]. Following this, ruthenium-based complexes were explored showing fewer side effects when compared to platinum-based agents and activity against Pt-resistant cancers [20][21][22]. Two ruthenium derivates, imidazolium trans-DMSO-imidazole-tetrachlororuthenate (NAMI-A) and imidazolium trans-[tetrachlorido(DMSO)(1H-imidazole)ruthenate(III)] (KP-1019), have been tested in clinical trials [22,23]. KP-1019 showed efficacy towards primary tumors, such as colon cancer, without triggering systemic toxicity, while NAMI-A was not cytotoxic but demonstrated activity against metastases. Moreover, NKP-1339 (the sodium salt analogue of KP1019, sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)]) has successfully completed a phase I clinical trial [24]. NKP-1339 is Ru(III) that binds to serum proteins albumin and transferrin, which transport and deliver the metallodrug to the tumor tissue. Once inside endosomes, NKP-1339 reduces to Ru(II). Recently, new designs of ruthenium complexes are emerging that include Ru(η 5 -C 5 H 5 ) core. This class of Ru(II) compounds demonstrates enhanced selectivity and effectiveness, for example ruthenium pyridocarbazole (DW1/2...

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“…1.25 mmol (0.42 g) PtCl 4 was reduced with 1 cm 3 formic acid in 10 cm 3 distilled water at room temperature. The complexes were synthesized starting from the as-obtained PtCl 2 solution, which was reacted with 2.5 mmol of substituted amines (2-aminonaphtalene for 1, 2-pyrimidinamine for 2 and 4-anilinophenol for 3) in 10 cm 3 methanol.…”

Section: Synthesis Of the Complexesmentioning

confidence: 99%

“…High number of different platinum complexes is synthesized with the aim to understand better the mode of action of platinum based antitumor drugs and to get new ones with fewer side effects. [3,4,5] Cisplatin and its analogues bind to the DNA in cancer cells [6,7,8]. These binding properties are studied and used in design and synthesis of new antibacterial drugs also [9,10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Holló

Szilágyi

Várhelyi

et al. 2016

J Therm Anal Calorim

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Three complexes of general formula PtCl 2 R 2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an) 2 Cl 2 ] (1), [Pt(pa) 2 Cl 2 ] (2) and [Pt(aph) 2 Cl 2 ] (3), where an is 2-aminonaphtalene, pa is 2-pyrimidinamine and aph is 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI-MS and NMR), and tested against selected Gram(+) and Gram(-) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.

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Adsorption of the cis-[Pt(NH3)2(P2O7)]2− (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues

Cited by 19 publications

References 40 publications

<p>Biomimetic hydroxyapatite nanocrystals are an active carrier for <em>Salmonella</em> bacteriophages</p>

<p>Biomimetic hydroxyapatite nanocrystals are an active carrier for <em>Salmonella</em> bacteriophages</p>

Nano-Based Systems and Biomacromolecules as Carriers for Metallodrugs in Anticancer Therapy

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

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