Adsorption of ketotifen onto some pharmaceutical excipients

Al-Nimry, Suhair S.; Assaf, Shereen M.; Jalal, I. M.; Najib, Naji M.

doi:10.1016/s0378-5173(96)04857-0

Cited by 39 publications

(9 citation statements)

References 4 publications

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“…Density influences pellet transit along the gastrointestinal tract. A critical density range to achieve a delay in gastric emptying and tentatively prolonged release of drug in the stomach from coated pellets was 2.4–2.8 g.cm – . The pellet densities produced with Prosolv SMCC 50 or Avicel PH101 according to the conditions in this study are found in the close range of 1.4 and 1.5 g.cm −3 (Table ).…”

Section: Resultsmentioning

confidence: 59%

“…For instance, some studies had showed the sorption of drug molecules onto the surface of MCC fibers as well as chemical incompatibility between MCC and various drugs. Also, MCC powders originated from different suppliers were found to alter physicochemical properties of pellets . Thus, researchers have evaluated alternative spheronization aids such as k‐carrageenan, powdered cellulose, blend of starch plus dextrin, and even use of new grades of MCC, which is known as MCCII with the intention to overcome some of the limitations of standard MCC .…”

Section: Introductionmentioning

confidence: 99%

“…Also, MCC powders originated from different suppliers were found to alter physicochemical properties of pellets. [3][4][5][6] Thus, researchers have evaluated alternative spheronization aids such as kcarrageenan, powdered cellulose, blend of starch plus dextrin, and even use of new grades of MCC, which is known as MCCII with the intention to overcome some of the limitations of standard MCC. 4,7,8 Also, some researchers suggested mixing MCC and other excipients.…”

Section: Introductionmentioning

confidence: 99%

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Silicified microcrystalline cellulose based pellets and their physicochemical properties

Mustafa

Chaw

2016

J of Applied Polymer Sci

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Silicified microcrystalline cellulose (SMCC), Prosolv® SMCC 50 was used as spheronization aid to manufacture pellets by extrusion and spheronization. Different ratios of SMCC to lactose were used to manufacture pellets using appropriate levels of water as liquid binder. Avicel PH101 based pellets were also manufactured for comparison of their physical properties. The ratio of liquid binder to spheronization aid was critical to produce pellets of desired size and shape. Extrudates composed of 20% aid could withstand only smaller spheronization force in order to be shaped into pellets. The successful products fulfilled the quality of pellets such as narrow size distribution and spherical in shape. The highest surface tensile strength was observed in pellets with equal ratio of lactose to SMCC while pellets having 20% aid disintegrated rapidly within 15 minutes. Furthermore, Prosolv® SMCC 50 based pellets possessed a stronger surface tensile strength when compared with Avicel PH101 based pellets. In conclusion, Prosolv® SMCC 50 has showed to be a good spheronization aid for extrusion and spheronization when used in the range of 20 to 80% content.

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Section: Resultsmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Silicified microcrystalline cellulose based pellets and their physicochemical properties

Mustafa

Chaw

2016

J of Applied Polymer Sci

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“…There are few drugs, e.g. ketotifen [13], ampicilline and amoxycilline [14], fluphenazine dihydrochloride and promehazine hydrochloride [15] have been investigated to find out the adsorption capacity of MCC.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have indicated that adsorption increases when pH of the solution increases. [13][14][15]20] This is attributed to the reduction of the solubility of the drug with the increase in pH [13]. Franz and Peck suggested [15] that it is due to the ionization of carboxyl groups on the cellulose surface.…”

Section: Introductionmentioning

confidence: 99%

Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres

Ashaduzzaman

Al-Rafin

Mustary

et al. 2016

IJPPE

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Abstract. Naturally engineered cellulosic fibres are of particular interest due to their diverse interfacial behavior; which could be well suited to operating interaction with functionalized drug. In the present work, interaction of Lidocaine (LC) hydrochloride, 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide was widely studied with cellulosic fibres i.e. cotton, jute and coir in presence of 0.1M HCl aqueous solution. In UV-Vis spectroscopy measurement, it is revealed that the highest interaction (adsorption 18 mg/g of fibres) of LC was occurred onto the cotton fibres surfaces from 3.5 mg/mL aqueous solution after 30 minutes gentle shaking. Kinetic studies in case of cotton fibres showed a linear relationship (R 2 = 0.9987) during desorption of LC upto 30 minutes at 25 o C temperature. The cotton fibres concentration was to be calculated 0.0085 g unit mol/L by considering the unit molecular weight of glucose unit. When 2.5 mg/mL (0.0108 g mol/L) LC drug solution was used then the ratio between glucose unit and LC drug was found to be 1.27. The interaction of LC was also increased direct-proportionally to the weight of cotton fibres. The resulting interaction phenomena of model LC would help us to deign dosage of anesthetic drug for specific physiological conditions.

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Excipient Characterization

Good

2016

Pharmaceutical Excipients

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Adsorption of ketotifen onto some pharmaceutical excipients

Cited by 39 publications

References 4 publications

Silicified microcrystalline cellulose based pellets and their physicochemical properties

Silicified microcrystalline cellulose based pellets and their physicochemical properties

Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres

Excipient Characterization

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