Adsorption of DNA onto Polypyrrole–Silica Nanocomposites

Adsorption of organic molecules on silica surface

“…It was inferred from the isotherms that (i) shielded intermolecular electrostatic forces, (ii) dehydration of the DNA and silica surface and (iii) intermolecular hydrogen bond formation in the DNA silica contact layer are the major contributing driving force for adsorption. Adsorption of DNA on polypyrrole powder (PPy-powder), a colloidal silica sol, was investigated by Saoudi et al [203]. The adsorption of DNA on polypyrrole (PPy)-silica monocomposite particles (untreated and amine or carboxylic acid functionalized) at neutral pH having sodium phosphate buffer was reported.…”

Polymer/silica composite of core–shell type by polymer swelling in TEOS

“…All these types of composites have promising properties for application as catalysts [24][25][26], specific sorbents [27,28], components in electronic devices [29,30], or advanced drug delivery systems [31,32] or in chemical sensing [33]. In many cases, the addition of inorganic component causes improvement of the mechanical and thermal stability of the polymer matrix [34][35][36].…”

Coupling of a Reagentless Electrochemical DNA Biosensor with Conducting Polymer Film and Nanocomposite as Matrices for the Detection of the HIV DNA Sequences

“…The different functionalization of the PPy network provides a suitable interface for localizing DNA. The DNA could be direct adsorbed onto conducting PPy surface (Saoudi et al 1997a;Saoudi et al 1997b), incorporated into PPy acting as a doping counterion (Wang et al 1999), and attached to the pyrrole ring to form reliable DNA-PPy grafting (Livache et al 1995;Livache et al 1998;Lassalle et al 2001a;Lassalle et al 2001b) to fabricate a DNAbased biosensor. Besides their surface confinement capability, conducting PPy polymer hold promise for inducing electrical signals accrued from DNA interactions.…”