Adsorption of DNA and Aptamers to Sodium Urate Crystals and Inhibition of Crystal Growth
Chuanyu Yang,
Yibo Liu,
Ka-Ying Wong
et al.
Abstract:An elevated level of blood uric acid (UA) can cause the formation of kidney stones, gout, and other diseases. We recently isolated a few DNA aptamers that can selectively bind to UA. In this work, we investigated the adsorption of a UA aptamer and random sequence DNA onto sodium urate crystals. Both DNA strands adsorbed similarly to urate crystals. In addition, both the UA aptamer and random DNA can inhibit the growth of urate crystals, suggesting a nonspecific adsorption mechanism rather than specific aptamer… Show more
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