Adsorption for perfluorooctanoic acid with graphitic‐phase carbon nitride and its HPLC fluorescence determination

Hu, Xiao; Yang, Rongguang; Jiang, Yinhua; Meng, Minjia; Liu, Zhanchao; Ni, Liang; Wu, Weifu; Liu, Hongwei

doi:10.1002/cjce.23625

Cited by 7 publications

(4 citation statements)

References 57 publications

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“…These methods also requires highly sophisticated equipment and training, and therefore is not readily available for widespread, rapid use in testing foods, commercial products or water samples (Hu et al, 2020;Shoemaker, 2020). Given the diversity of PFAS contaminated materials, the range of concentrations necessary for testing, and desire for portable and flexible testing, there is an increasing need to develop rapid and robust methodologies for PFAS detection.…”

mentioning

confidence: 99%

Engineering human liver fatty acid binding protein for detection of poly‐ and perfluoroalkyl substances

Mann

Tang

Berger

2021

Biotech & Bioengineering

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Per-and polyfluoroalkyl substances (PFAS) are a large group of synthetic fluorinated chemicals with surface active and water-repellent properties. The combination of wide-spread use in numerous consumer and industrial products and extended biological half-lives arising from strong carbon-fluorine bonds has led to significant accumulation of PFAS in humans. As most human interaction with PFAS comes from ingestion, it is important to be able to detect PFAS in drinking water as well as in agricultural water. Here we present an approach to designing a fluorescence-based biosensor for the rapid detection of PFAS based on human liver fatty acid binding protein (hLFABP). Introduction of solvatochromic fluorophores within the ligand binding pocket (L50) allowed for intrinsic detection of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) via blue-shifts in fluorescence emission spectra. Initially, a single tryptophan mutation (L50W) was found to be able to detect PFOA with a limit of detection (LOD) of 2.8 ppm. We improved the sensitivity of the biosensor by exchanging tryptophan for the thiol reactive fluorophore, acrylodan. The acrylodan conjugated C69S/F50C hLFABP variant is capable of detecting PFOA, PFOS, and PFHxS in PBS with LODs of 112 ppb, 345 ppb, and 1.09 ppm, respectively. The protein-based sensor is also capable of detecting these contaminants at similar ranges in spiked environmental water samples, including samples containing an interfering anionic surfactant sodium dodecyl sulfate. Overall, this study demonstrates engineered hLFABP is a useful platform for detection of PFAS in environmental water samples and highlights its ease of use and versatility in field applications.

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confidence: 99%

Engineering human liver fatty acid binding protein for detection of poly‐ and perfluoroalkyl substances

Mann

Tang

Berger

2021

Biotech & Bioengineering

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“…Adsorption is considered an effective separation technique for PFAS due to its low cost, high efficiency, simple operation, and insensitivity toward toxic substances. Besides conventional adsorbent materials ( SI Table S1 )—e.g., granular and powdered activated carbon—few other efficient adsorbents— such as silica [ 35 ], zeolites [ 48 ], aminated rice husk [ 49 ], graphitized carbon nitride—g-C 3 N 4 [ 50 ], metal organic frameworks—MOFs [ 51 , 52 ], covalent organic frameworks—COFs [ 53 ], and modified chitosan [ 54 ]—have been synthesized and used. PFAS adsorption mainly depends on two predominant forces, namely electrostatic [ 55 ] and hydrophobic iterations [ 56 , 57 , 58 ].…”

Section: Current Treatment Approachesmentioning

confidence: 99%

A Review on Removal and Destruction of Per- and Polyfluoroalkyl Substances (PFAS) by Novel Membranes

Das

Ronen

2022

Membranes

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Per- and Polyfluoroalkyl Substances (PFAS) are anthropogenic chemicals consisting of thousands of individual species. PFAS consists of a fully or partly fluorinated carbon–fluorine bond, which is hard to break and requires a high amount of energy (536 kJ/mole). Resulting from their unique hydrophobic/oleophobic nature and their chemical and mechanical stability, they are highly resistant to thermal, chemical, and biological degradation. PFAS have been used extensively worldwide since the 1940s in various products such as non-stick household items, food-packaging, cosmetics, electronics, and firefighting foams. Exposure to PFAS may lead to health issues such as hormonal imbalances, a compromised immune system, cancer, fertility disorders, and adverse effects on fetal growth and learning ability in children. To date, very few novel membrane approaches have been reported effective in removing and destroying PFAS. Therefore, this article provides a critical review of PFAS treatment and removal approaches by membrane separation systems. We discuss recently reported novel and effective membrane techniques for PFAS separation and include a detailed discussion of parameters affecting PFAS membrane separation and destruction. Moreover, an estimation of cost analysis is also included for each treatment technology. Additionally, since the PFAS treatment technology is still growing, we have incorporated several future directions for efficient PFAS treatment.

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“…Despite its sensitivity to mobile phase composition and pH, fluorescence is 100‐1000 times more sensitive than UV‐Vis and offers excellent selectivity and detection limits below 1 pg [ 54 ] ; it is the ideal technique to determine contaminants in environmental and food samples. [ 55–58 ]…”

Section: Detectorsmentioning

confidence: 99%

“…Eng.) : “Adsorption for Perfluorooctanoic Acid with Graphitic‐Phase Carbon Nitride and its HPLC Fluorescence Determination” and “Photocatalytic Degradation of Dimethyl Sulphoxide by CdS/TiO2 Core/Shell Catalyst: A Novel Measurement Method.” [ 55,68 ] There are the references to HPLC in 2016 and 2017 in the in the field Topic; however, 23 articles mention it in the methods section of Can. J. Chem.…”

Section: Applicationsmentioning

confidence: 99%

Experimental methods in chemical engineering: High performance liquid chromatography—HPLC

et al. 2021

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High performance liquid chromatography (HPLC) identifies compounds in a sample and quantifies their concentration. The instrument consists of an injector that introduces a μL sample to a mobile phase that carries the analytes across a column filled with an adsorbing substance. The analytes adsorb and desorb at different rates as they flow down the column and are thereby separated. Detectors record a signal proportional to the concentration of the analyte in the mobile phase. Laboratories apply modern HPLC systems for research and development, quality control, safety, and validation. Academia and industry resort to HPLC to purify, identify, and characterize a wide variety of molecules at all stages of a process. Developing an HPLC analytical method is a long and laborious process requiring standards, calibration curves, derivatization, and multiple tests to identify an appropriate column, stationary phase, flow rate, temperature, and mobile phase. Optimal operating conditions maintain a good resolution (high signal‐to‐noise ratio and low peak overlap) while minimizing analysis time. Web of Science Core Collection indexed 8900 articles in 2019, which is relatively few compared to x‐ray and scanning electron microscopy. However, it is such an ubiquitous technique and we estimate that the number of articles that report it in the experimental section is an order of magnitude higher. The bibliometric analysis of the keywords identified four research clusters: phenolics and flavonoids, extraction and pharmacokinetics, in vitro and oxidative stress, and optimization. Here, we detail a walkthrough for the basic steps required to develop a chromatographic method.

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Adsorption for perfluorooctanoic acid with graphitic‐phase carbon nitride and its HPLC fluorescence determination

Cited by 7 publications

References 57 publications

Engineering human liver fatty acid binding protein for detection of poly‐ and perfluoroalkyl substances

Engineering human liver fatty acid binding protein for detection of poly‐ and perfluoroalkyl substances

A Review on Removal and Destruction of Per- and Polyfluoroalkyl Substances (PFAS) by Novel Membranes

Experimental methods in chemical engineering: High performance liquid chromatography—HPLC

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