Adsorption behavior of proteins on temperature-responsive resins

Poplewska, Izabela; Muca, Renata; Strachota, Adam; Pia̧tkowski, Wojciech; Antos, Dorota

doi:10.1016/j.chroma.2013.11.040

Cited by 23 publications

(14 citation statements)

References 30 publications

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“…Poly( N -isopropylacrylamide) was prepared using free radical polymerisation in water as was discussed in Refs. [ 54 , 63 , 67 , 68 ]. The PNIPA used in this paper is this same sample a that in Ref.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Physical Aging Tracked by Advanced Thermal Analysis of Poly(N-Isopropylacrylamide): A Smart Polymer for Drug Delivery System

2020

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Poly(N-isopropylacrylamide) (PNIPA), as a smart polymer, can be applied for drug delivery systems. This amorphous polymer can be exposed on a structural recovery process during the storage and transport of medicaments. For the physical aging times up to one year, the structural recovery for PNIPA was studied by advanced thermal analysis. The structural recovery process occurred during the storage of amorphous PNIPA below glass transition and could be monitored by the differential scanning calorimetry (DSC). The enthalpy relaxation (recovery) was observed as overshoot in change heat capacity at the glass transition region in the DSC during heating scan. The physical aging of PNIPA was studied isothermally at 400.15 K and also in the non-isothermal conditions. For the first time, the structural recovery process was analyzed in reference to absolute heat capacity and integral enthalpy in frame of their equilibrium solid and liquid PNIPA.

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Section: Methodsmentioning

confidence: 99%

Long-Term Physical Aging Tracked by Advanced Thermal Analysis of Poly(N-Isopropylacrylamide): A Smart Polymer for Drug Delivery System

2020

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“…Poly( N ‐isopropylacrylamide) (PNIPA) is one of the most studied thermosensitive polymers . The hydrogels based on crosslinked PNIPA display a volume phase transition at around 32 °C and have potential applications in numerous fields, including drug delivery systems, actuators and sensors and enzyme immobilization . A drawback of these hydrogels is their limited extensibility and hence brittleness, because of their inhomogeneous polymer network structure .…”

Section: Introductionmentioning

confidence: 99%

Tremendous reinforcing, pore-stabilizing and response-accelerating effect of in situ generated nanosilica in thermoresponsive poly(N -isopropylacrylamide) cryogels

Šlouf

Matějka

2017

Polym. Int

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The tremendous reinforcing and pore-stabilizing effect of in situ formed nanosilica in a highly porous temperature-responsive poly(N-isopropylacrylamide) (PNIPA) matrix is demonstrated. A very weakly crosslinked semi-liquid hydrogel can be reinforced to the point that it displays a fast, extensive and nearly symmetric temperature-responsiveness in combination with an acceptable modulus. In soft but solid porous PNIPA, only 0.6 wt% of the nanofiller is sufficient to stabilize the pores against collapse upon de-swelling, thus enabling ultrafast responsiveness. A spectacular effect is achieved with dried porous PNIPA (matrix is glassy, T g ≈ 140 ∘ C), which in the case of optimal nanosilica amounts can re-swell in only 3 min. The key importance of efficient hydrogen bridging between PNIPA and SiO 2 is demonstrated by comparing in situ formed nanosilica with similarly sized commercial Ludox particles, the surface of which is saturated with ammonia (for stabilization). Synthesis parameters like the amount of crosslinker and of nanosilica were varied in a wide range, in order to achieve the fastest possible responsiveness of the hydrogels in combination with a high modulus. The porosity, nanosilica distribution, moduli, temperature-dependent swelling as well as the swelling kinetics of the gels were determined as functions of contents of crosslinker and nanosilica.

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“…The latter three effects are achieved with chemically modified PNIPAm. The stimuliresponsivity of PNIPAm opens various potential application fields, including mechanical actuators [9,10], artificial muscles [11,12], components of artificial organs [13][14][15], controlled drug release [16,17], enzyme immobilization [18,19], solute extraction and separation [20], or nanovalves (e.g. PNIPAm particles in silica: [21]).…”

Section: Introductionmentioning

confidence: 99%

Super-porous nanocomposite PNIPAm hydrogels reinforced with titania nanoparticles, displaying a very fast temperature response as well as pH-sensitivity

Huerta-Ángeles

Hishchak

Strachota

et al. 2014

European Polymer Journal

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Adsorption behavior of proteins on temperature-responsive resins

Cited by 23 publications

References 30 publications

Long-Term Physical Aging Tracked by Advanced Thermal Analysis of Poly(N-Isopropylacrylamide): A Smart Polymer for Drug Delivery System

Long-Term Physical Aging Tracked by Advanced Thermal Analysis of Poly(N-Isopropylacrylamide): A Smart Polymer for Drug Delivery System

Tremendous reinforcing, pore-stabilizing and response-accelerating effect of in situ generated nanosilica in thermoresponsive poly(N -isopropylacrylamide) cryogels

Super-porous nanocomposite PNIPAm hydrogels reinforced with titania nanoparticles, displaying a very fast temperature response as well as pH-sensitivity

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