Adsorption behavior of DODAB/DPPC vesicles on silica

Electrostatic effects on deposition of multiple phospholipid bilayers at oxide surfaces

“…3 and 4). Work by Carmona-Ribeiro and co-workers investigating DPPC adsorption on silica nanoparticles over a small pH range (6.4-8.2) [72], and over a range of ionic strengths (0-150 mM NaCl) at pH 6.3 [119] yielded isotherms of similar shape to those presented here. Adsorption may have been underestimated in their studies due to aggregation of their Aerosil OX-50 particles (mean diameter = 50 nm).…”

Dynamics of supported lipid bilayer deposition from vesicle suspensions

“…In has been found that in order to deposit onto solid, oppositely charged surfaces, charged bilayers also have certain requirements of bilayer fluidity [35]. DODAB vesicles are also found in the rigid gel state at room temperature [36] and closed DODAB vesicles are difficult to disrupt for bilayer deposition so that previously disrupted vesicles or bilayer fragments had to be used in order to optimize gel bilayer deposition on silica [37].…”

Lipid-based Biomimetics in Drug and Vaccine Delivery

“…The interaction between lipids and particles has been reviewed over the last two decades in a few review articles and book chapters (Carmona-Ribeiro, 1992;Carmona-Ribeiro and Lessa, 1999;Carmona-Ribeiro, 2001 a,b;Carmona-Ribeiro, 2003;Carmona-Ribeiro et al, 2006;Carmona-Ribeiro, 2006;CarmonaRibeiro, 2007;Petri & Carmona-Ribeiro, 2007;Mamizuka & Carmona-Ribeiro, 2007) and lately other excellent reviews appeared in the literature (Bulte & De Cuyper, 2003;Troutier & Ladavière, 2007;Al-Jammal & Kostarelos). Figure 4 illustrated possible assemblies resulting from the interaction between bilayer-forming lipids and particles as depicted from experimental evidences (Carmona-Ribeiro & Midmore, 1992;Carmona-Ribeiro & Herrington, 1993;Rapuano & Carmona-Ribeiro, 1997;Carmona-Ribeiro & Lessa, 1999;Moura & Carmona-Ribeiro, 2003;Moura & Carmona-Ribeiro, 2005;Moura & Carmona-Ribeiro, 2007).…”

“…Using encapsulation of radiolabeled D-glucose in the vesicles, they have shown that lipid adsorption on particles did not release the marker, an indication of adsorption of an intact vesicle layer onto the particles. Indeed, in the rigid gel state, bilayers are more difficult to disrupt as was the case for DODAB/DPPC vesicles adsorbing on silica (Moura & Carmona-Ribeiro, 2007), with tightly packed bilayers (Sobral et al, 2008). There were important differences between the interactions that involve liposomes in the liquid-crystalline or in the gel state.…”

“…Glass microspheres coated with phospholipid layers evaluated the binding specificity of enzymes on cell surface (Obringer et al 1995) or quantified lipid-antibodies binding (Kiser et al, 1998). Recent work continues to investigate lipid-supporting particles based on minerals Nordlund et al 2009;Ahmed & Wunder, 2009;Xu et al, 2009;Oleson & Sahai, 2008;Pyiasena et al, 2008;Senarath-Yapa et al 2007;Moura & Carmona-Ribeiro, 2007;Parida et al, 2006), polymers Jha & Bose, 2009;Thevenot et al, 2008;Bershteyn et al 2008;Zuzzi et al, 2008;Troutier et al, 2005;Pereira et al, 2004), metals eg magnetoliposomes for biomedical applications or contrast agents in magnetic resonance imaging (Bulte & De Cuyper, 2003) or biological cells as templating cores to be dissolved to obtain capsules (Ge et al, 2003) or viruses for enhancing adenovirus tumor targeting in vivo (Singh et al, 2008). Polymer hollow capsules were produced by Möhwald and coworkers (Ge et al, 2003) from the polyelectrolyte layer-by-layer technique on biological cells.…”