Adsorption and release studies of new cephalosporin from chitosan-g-poly(glycidyl methacrylate) microparticles

Cigu, Toni Andor; Vasiliu, Silvia; Racoviţă, Stefania; Lionte, Cătălina; Şunel, Valeriu; Popa, Marcel; Cheptea, Corina

doi:10.1016/j.eurpolymj.2016.07.011

Cited by 21 publications

(13 citation statements)

References 49 publications

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“…(a) The diameters of B microparticles are smaller than those of A microparticles due to the fact that gellan works as a suspension stabilizer in combination with PVA. The same observations were also found in the case of grafting of xanthan and chitosan onto crosslinked networks based on GMA . (b) The diameters of D microparticles are higher due to the grafting of polysaccharide onto the surface of A microparticles.…”

Section: Resultssupporting

confidence: 76%

“…Porous microparticles based on GMA and EGDMA, DEGDMA or TEGDMA, named A microparticles, were synthesized by the same experimental procedure as the G 1–3 microparticles presented in our previous work . The difference between the above mentioned materials is represented by the type of porogenic agent used in the synthesis, namely toluene for the preparation of G microparticles and N ‐butyl acetate for the preparation of A microparticles.…”

Section: Methodsmentioning

confidence: 99%

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Porous microparticles based on methacrylic copolymers and gellan as drug delivery systems

Vasiliu¹,

Lungan²,

Racoviţă³

et al. 2019

Polymer International

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Two types of porous microparticles based on glycidyl methacrylate, dimethacrylic monomers (ethylene glycol dimethacrylate, diethylene glycol dimethacrylate and triethylene glycol dimethacrylate) and gellan were prepared by two methods. The first method was aqueous suspension polymerization in the presence of N-butyl acetate as porogenic agent when the crosslinking and grafting reactions were achieved in a single step. The second method was based on the reaction between hydroxyl groups belonging to gellan and the epoxy groups situated on the surface of porous microparticles based on glycidyl methacrylate and dimethacrylic monomers in basic medium. The microparticles with and without gellan were characterized by Fourier transform infrared spectroscopy, SEM, AFM and TGA. Also, the porous structure was investigated in terms of pore volume, porosity and specific surface. The swelling behaviour in aqueous solution with different pH values as well as sorption studies of cefuroxime sodium salt onto porous microparticles were investigated. The presence of gellan in the structure of the microparticles leads to porous materials characterized by higher specific surface areas (S sp = 78-140 m 2 g-1), higher swelling capacities (S w = 162%-365%) and higher sorption capacities of the drug (q e = 101-147 mg g-1) compared to microparticles without gellan in their structures (S sp = 73-85 m 2 g-1 ; S w = 139%-209%; q e = 70-110 mg g-1).

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Section: Resultssupporting

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Porous microparticles based on methacrylic copolymers and gellan as drug delivery systems

Vasiliu¹,

Lungan²,

Racoviţă³

et al. 2019

Polymer International

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“…Due to their properties like, higher surface area and good swelling capacities, the C 1‐3 microparticles can be used in pharmaceutical field as drug delivery systems. In our previous work we demonstrated that C 1 microparticles are good candidates in the preparation of sustained drug delivery system for oral administration of cephalosporin from indazole class in order to treat infectious diseases . In this study, preliminary adsorption studies of copper (Figure ) have been performed, aiming the eventual use of C 1‐3 microparticles as adsorbents in medicine (for Wilson disease treatment) or in waste water purification.…”

Section: Resultsmentioning

confidence: 99%

Design of Porous Microparticles Based on Chitosan and Methacrylic Monomers

Vasiliu¹,

Lungan²,

Gugoasa

et al. 2019

ChemistrySelect

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Starting from glycidyl methacrylate, three dimethacrylic monomers (mono, di and triethylene glycol dimethacrylate) and chitosan, various types of porous microparticles were obtained by suspension polymerization technique. Also, using the same technique the un‐grafted porous microparticles were obtained by reaction between glycidyl methacrylate and dimethacrylic monomers. The successful grafting reaction of chitosan onto synthetic polymer networks was highlighted by FTIR spectroscopy, scanning electron microscopy, atomic force microscopy and thermogravimetric analysis. The dimensional analysis of all type of microparticles was performed by laser diffraction while the specific surface areas were determined by means of dynamic vapor sorption. Grafting of polysaccharide onto crosslinked networks has led to the preparation of polymeric materials with high specific surface area (50‐160 m2/g) and better swelling capacities (101‐106%) compared to microparticles based on glycidyl methacrylate and dimethacrylic monomers [(31‐69 m2/g) and (39‐57%), respectively]. Furthermore, the sorption properties of grafted and un‐grafted microparticles were tested using Cu(II) solution. The highest retention capacity value of Cu(II) (41.7 mg/g) was obtained when the C1 microparticles were used in the adsorption studies.

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“…In the 20th century, the development of dental techniques has increased the options for tooth treatment. Furthermore, the introduction of controlled drug delivery systems [ 17 , 18 , 19 ] in dentistry became a necessity, due to the fact that they offer clearly superior advantages over traditional methods, such as the following: The drug is released gradually, ensuring a constant concentration in the body at the value corresponding to the therapeutic field; The approach helps their metabolism and excretion; The side effects of drugs, caused by either overdoses or by their aggression, sometimes to both diseased and healthy cells, are reduced [ 20 ]. …”

Section: History Of Dental Materialsmentioning

confidence: 99%

The Benefits of Smart Nanoparticles in Dental Applications

Vasiliu¹,

Racoviţă²,

Gugoasa

et al. 2021

IJMS

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Dentistry, as a branch of medicine, has undergone continuous evolution over time. The scientific world has focused its attention on the development of new methods and materials with improved properties that meet the needs of patients. For this purpose, the replacement of so-called “passive” dental materials that do not interact with the oral environment with “smart/intelligent” materials that have the capability to change their shape, color, or size in response to an externally stimulus, such as the temperature, pH, light, moisture, stress, electric or magnetic fields, and chemical compounds, has received much attention in recent years. A strong trend in dental applications is to apply nanotechnology and smart nanomaterials such as nanoclays, nanofibers, nanocomposites, nanobubbles, nanocapsules, solid-lipid nanoparticles, nanospheres, metallic nanoparticles, nanotubes, and nanocrystals. Among the nanomaterials, the smart nanoparticles present several advantages compared to other materials, creating the possibility to use them in various dental applications, including preventive dentistry, endodontics, restoration, and periodontal diseases. This review is focused on the recent developments and dental applications (drug delivery systems and restoration materials) of smart nanoparticles.

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Adsorption and release studies of new cephalosporin from chitosan-g-poly(glycidyl methacrylate) microparticles

Cited by 21 publications

References 49 publications

Porous microparticles based on methacrylic copolymers and gellan as drug delivery systems

Porous microparticles based on methacrylic copolymers and gellan as drug delivery systems

Design of Porous Microparticles Based on Chitosan and Methacrylic Monomers

The Benefits of Smart Nanoparticles in Dental Applications

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