Adsorption and desorption behavior of natural and synthetic active compounds on hydroxyapatite-based nanocomposites

Barabáş, Réka; Farkas, Noémi-Izabella; Nagy, Csaba L.; Cadar, Oana; Moisa, Corina; Bizo, Liliana

doi:10.1016/j.ceramint.2020.11.226

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…Hap was prepared according to our previously reported method [ 41 ], but a brief description of the synthesis is presented below. The (NH 4 ) 2 HPO 4 aqueous solution with a pH of 11 was added to the Ca(NO 3 ) 2 × 4 H 2 O solution with the same pH using a peristaltic pump under constant stirring.…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Farkas

Marincaș

Barbu–Tudoran

et al. 2023

JFB

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Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model.

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Section: Methodsmentioning

confidence: 99%

Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Farkas

Marincaș

Barbu–Tudoran

et al. 2023

JFB

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“…The additives, structural modifications and the adsorption efficiency were greatly influenced by the nature of the adsorbent. Synthetic and natural active substances showed different release profiles of the same carrier [9]. Functionalized coated HAP nanoparticles were used by others for sustained release of amoxicillin which was confirmed on animal experiments and was assigned to the antibacterial and bioactive properties of the used nanostructures [14].…”

Section: Introductionmentioning

confidence: 98%

“…In our previous researches, we already investigated the sorption properties of HAP and various HAP-based composites with different adsorbates [9][10][11][12][13]. The additives, structural modifications and the adsorption efficiency were greatly influenced by the nature of the adsorbent.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite and Silicon-Modified Hydroxyapatite as Drug Carriers for 4-Aminopyridine

et al. 2021

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Adsorption and desorption properties of nano-hydroxyapatite (HAP) and silicon-modified hydroxyapatite (Si–HAP) were investigated with 4-aminopyridine (fampridine-4AP). The novelty of this research is the investigation of the suitability of the previously mentioned carriers for drug-delivery of 4AP. UV-VIS spectrophotometric results showed that the presence of silicon in the carrier did not significantly affect its adsorption capacity. The success of the adsorption was confirmed by thermal analysis (TG/DTA), scanning electron microscopy (SEM)/energy dispersive X-ray (EDX), Fourier transform infrared (FTIR) spectroscopy, and X-ray powder diffraction (XRPD). Drug release experiments, performed in simulated body fluid (SBF), revealed a drug release from Si–HAP that was five times slower than HAP, explained by the good chemical bonding between the silanol groups of the carrier and the 4AP functional groups. The electrochemical measurements showed a value of the polarization resistance of the charge transfer (Rct) more than five times smaller in the case of Si–HAP coating loaded with 4AP, so the charge transfer process was hindered. The electrochemical impedance results revealed that electron transfer was inhibited in the presence of 4AP, in concordance with the previously mentioned strong bonds. The silicon substitution in HAP leads to good chemical bonding with the drug and a slow release, respectively.

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