Adsorption and characterization of palygorskite-isoniazid nanohybrids

Carazo, E.; Borrego-Sánchez, Ana; García‐Villén, Fátima; Sánchez-Espejo, Rita; Viseras, César; Cerezo, Pilar; Aguzzi, Carola

doi:10.1016/j.clay.2017.12.027

Cited by 53 publications

(35 citation statements)

References 22 publications

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“…In particular, VHS shows d001 basal reflection at 7.5º 2θ which indicates an interlayer space of 12 Å according to Bragg’s law. These results are consistent with the literature 24,31. Diffractogram of VHS-NF also shows typical reflections of montmorillonite with the exception of the basal reflection d001, which shifts to lower 2θ values (5,94º 2θ) in comparison with the pristine clay mineral.…”

Section: Resultssupporting

confidence: 92%

“…X-ray diffractogram patterns of the nanohybrid and pristine components are plotted in Figure 2. VHS diffractogram shows reflections ascribable to a highly pure homoionic Na montmorillonite, as previously described 16,24,29,30Figure 2XRPD diffraction patterns of NF, VHS and VHS-NF. Abbreviations: NF, norfloxacin; VHS, montmorillonite; VHS-NF, montmorillonite/norfloxacin nanocomposite.…”

Section: Resultssupporting

confidence: 63%

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<p>Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds</p>

García‐Villén

Faccendini

Aguzzi

et al. 2019

IJN

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Background: Chronic cutaneous wounds represent a major issue in medical care and are often prone to infections. Purpose: The aim of this study was the design of a clay mineral-drug nanocomposite based on montmorillonite and norfloxacin (NF, antimicrobial drug) as a powder for cutaneous application, to enhance wound healing in infected skin lesions. Methods: The nanocomposite has been prepared by means of an intercalation solution procedure. Adsorption isotherm, solid-state characterization of the nanocomposite, drug loading capacity and its release have been performed. Moreover, cytocompatibility, in vitro fibroblast proliferation and antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus were assessed. Results: The clay drug adsorption isotherm demonstrates that the mechanism of NF intercalation into montmorillonite galleries is the adsorption as one single process, due to the charge–charge interaction between protonated NF and negatively charged montmorillonite edges in the interlayer space. Nanocomposite is biocompatible and it is characterized by antimicrobial activity greater than the free drug: this is due to its nanostructure and controlled drug release properties. Conclusion: Considering the results obtained, NF–montmorillonite nanocomposite seems a promising tool to treat infected skin lesions or skin wounds prone to infection, as chronic ulcers (diabetic foot, venous leg ulcers) and burns.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 63%

<p>Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds</p>

García‐Villén

Faccendini

Aguzzi

et al. 2019

IJN

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“…The absorption bands around 3700–3500 cm −1 and 3400–3300 cm −1 are mainly due to the stretching vibration of the O-H group of the structural hydroxyl group and water molecule [ 57 , 58 ]. In FTIR spectra of Pal, the absorption band at about 1600 cm −1 corresponds to the antisymmetric stretching vibration of zeolite water and adsorbed water [ 48 , 59 , 60 ]. The absorption band of 791~1198 cm −1 is the anti-symmetric stretching vibration peak of Si-O bond [ 59 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

“…At 550 °C, the residual mass of betanin is only 25.57%, indicating that natural pigments have poor high temperature resistance. In case of raw Pal, the degradation process occurs in the three stages of 30–550 °C, which are related to the removal of the adsorbed water, zeolitic H 2 O, the bound OH 2 , and part of structural OH, respectively [ 39 , 48 , 60 , 62 ]. As for raw Hal, it shows an initial slight mass loss from room temperature, which is attributed to the evaporation of the physically adsorbed water and the interlayer H 2 O.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Eco-Friendly Betanin Hybrid Materials Based on Palygorskite and Halloysite

Wang

et al. 2020

Materials

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Eco-friendly betanin/clay minerals hybrid materials with good stability were synthesized by combining with adsorption, grinding, and heating treatment using natural betanin extracted from beetroot and natural 2:1 type palygorskite or 1:1 type halloysite. After incorporation of clay minerals, the thermal stability and solvent resistance of natural betanin were obviously enhanced. Due to the difference in the structure of palygorskite and halloysite, betanin was mainly adsorbed on the outer surface of palygorskite or halloysite through hydrogen-bond interaction, but also part of them also entered into the lumen of Hal via electrostatic interaction. Compared with palygorskite, hybrid materials prepared with halloysite exhibited the better color performance, heating stability and solvent resistance due to the high loading content of betanin and shielding effect of lumen of halloysite.

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“…The use of nanoparticles as vehicles for effective drug delivery in TB treatment have been proposed to increase drug bioavailability, protect from degradation and control release . A particular type of inorganic low cost nanoparticles is being proposed as potential excipients in the improvement of TB, and in particular some interesting hybrids have been recently designed . Halloysite is a two‐layered aluminosilicate chemically similar to kaolin, with prevailing hollow tubular structure in the nanometer range .…”

Section: Introductionmentioning

confidence: 99%

Halloysite nanotubes as tools to improve the actual challenge of fixed doses combinations in tuberculosis treatment

Carazo

Sandri

Cerezo

et al. 2019

J Biomedical Materials Res

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Halloysite nanotubes (HLNTs) were used as nanocarriers of the tuberculostatic agent isoniazid (INH), a BCS (Biopharmaceutics Classification System) class III drug. Self‐assembling nanohybrids (INH‐loaded HLNTs) with an average outer diameter of 90 nm and polydispersity index of 0.7 approximately, were obtained by spontaneous adsorption of INH molecules to HLNTs powder in aqueous medium. The nanohybrids were aimed to improve oral drug bioavailability and reduce physicochemical incompatibility of INH with other concomitantly administered tuberculostatic agents. In vitro drug release from INH‐loaded HLNTs was successfully fitted to a diffusive kinetic law founded on the adsorption–desorption equilibrium between drug molecules in solution and solid inorganic excipients. INH‐loaded HLNTs showed good in vitro biocompatibility toward Caco‐2 cells at the concentrations studied (up to 1233 μg/mL), with improved cell proliferation. Permeability tests showed that INH transport across Caco‐2 cellular membranes was greatly enhanced and fluorescent microscopy confirmed that the drug encapsulated into nanohybrid was effectively internalized by the cells. INH‐loaded HLNTs enhanced stability of the drug in presence of other tuberculostatic agents, both in binary and quaternary combinations. It has been demonstrated that simple interaction between INH with HLNTs leads to drug permeability and stability improvements that could greatly facilitate the design of multiple drug dosage forms, an actual challenge in oral treatment of tuberculosis. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Adsorption and characterization of palygorskite-isoniazid nanohybrids

Cited by 53 publications

References 22 publications

<p>Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds</p>

<p>Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds</p>

Fabrication of Eco-Friendly Betanin Hybrid Materials Based on Palygorskite and Halloysite

Halloysite nanotubes as tools to improve the actual challenge of fixed doses combinations in tuberculosis treatment

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