Adropin and Inflammation Biomarker Levels in Male Patients With Obstructive Sleep Apnea: A Link With Glucose Metabolism and Sleep Parameters

Božić, Joško; Borovac, Josip Anđelo; Galić, Tea; Kurir, Tina Tičinović; Šupe‐Domić, Daniela; Đogaš, Zoran

doi:10.5664/jcsm.7204

Cited by 41 publications

(28 citation statements)

References 52 publications

(52 reference statements)

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“…Kumar et al hypothesize that adropin is involved in regulation of metabolic homeostasis and that its deficiency has a negative effect on glucose homeostasis and carries an increased risk of developing insulin resistance and T2DM progression [6][7][8] . Our study provided data on the effect of 3-month liraglutide treatment applied once daily in combination with metformin in male obese patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

“…Ten years ago, Kumar et al identified a new protein named adropin, which is believed to play an important role in metabolic homeostasis, insulin resistance prevention, dyslipidemia and impaired glucose tolerance [6][7][8] . It is encoded by the ENHO gene (Energy Homeostasis Associated Gene) and its expression in the liver, heart, brain and coronary arteries is diet dependent 6 .…”

Section: Introductionmentioning

confidence: 99%

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Adropin – Potential Link in Cardiovascular Protection for Obese Male Type 2 Diabetes Mellitus Patients Treated with Liraglutide

Kurir¹

2020

ACC

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The aim of this study was to determine plasma adropin concentration and parameters of insulin resistance in obese male type 2 diabetes mellitus (T2DM) patients before and after 3-month liraglutide treatment. In this interventional study, we enrolled 15 obese male T2DM patients with body mass index (BMI) >35 kg/m 2 , uncontrolled disease and HbA 1c >7.5%, having previously taken taking two oral antidiabetic drugs. We modified their therapy to metformin and liraglutide for the next three months. After three months of liraglutide treatment, we observed significant decrease in body weight (from 111.5±18.7 kg to 109.2±17.5 kg, p=0.016) and BMI (from 40.9±7.3 to 40.1±7.0 kg/m 2 , p=0.021). Plasma adropin concentration increased significantly (p=0.003) compared with baseline. Fasting plasma insulin level decreased from 17.79±6.53 to 13.38±3.51 mU/L (p=0.002), fasting plasma glucose level decreased from 8.66±3.07 to 7.41±2.21 mmol/L (p=0.004) and HbA 1c decreased from 7.98±0.70% to 7.26±0.36% (p=0.003). Insulin resistance presented as HOMA-IR decreased significantly from 7.30±5.19 to 4.52±2.61 (p=0.002). Systolic blood pressure, lipid status, liver and kidney function improved, but not reaching statistical significance. Treating obese male T2DM patients with liraglutide resulted in a significantly higher plasma adropin concentration, significant weight loss and improved parameters of insulin resistance, i.e. decreased fasting plasma insulin, plasma glucose levels and HOMA-IR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adropin – Potential Link in Cardiovascular Protection for Obese Male Type 2 Diabetes Mellitus Patients Treated with Liraglutide

Kurir¹

2020

ACC

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“…The underlying mechanism may be related to the upregulation of eNOS activity by adropin, and the produced NO can negatively regulate inflammatory mediators. Furthermore, it can impede the leukocyte extravasation and movement process regulated by TNF-α, thereby applying its anti-inflammatory effects [41].…”

Section: Association Between Adropin and Other Inflammatory Diseasesmentioning

confidence: 99%

A Review of Adropin as the Medium of Dialogue between Energy Regulation and Immune Regulation

Zhang

Chen

Lin

et al. 2020

Oxidative Medicine and Cellular Longevity

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Adropin is a secretory protein encoded by the energy balance gene and is closely associated with regulation of energy metabolism and insulin resistance. The clinical findings demonstrated its decreased expression in various inflammatory diseases, its negative correlation with the expression levels of inflammatory cytokines, and its potential anti-inflammatory effects. We speculate that adropin plays a pivotal regulatory role in immune cells and inflammatory factors. In this study, we reviewed the advances in researches concentrated on immunological effects of adropin.

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“…Among adult participants, eighteen studies were performed with Caucasians [ Table 1 presents the characteristics of the 55 studies included in the meta-analysis. Forty-six studies [16,[28][29][30][31][32][33][34][35][36][38][39][40][41][43][44][45][46][47][48][49][50][51][52]54,[56][57][58][59][60][61][62][63][64][65][67][68][69][70][71][72]75,76,[78][79][80] reported serum or plasma TNF-α concentrations in adults, and nine studies [14,37,...…”

Section: Search Strategiesmentioning

confidence: 99%

Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Imani

Sadeghi

Khazaie

et al. 2020

Life

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Background: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. Methods: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis factor alpha (TNF-α) levels in individuals with and without OSAS, we performed a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases to find relevant articles published up to 1 February 2020. Results: Fifty-five (adults: 29 studies on serum and 17 studies on plasma; children: 4 studies on serum and 5 studies on plasma) were included and analyzed. Always compared to age-matched healthy controls, the pooled MDs were as follows: adults, serum: 10.22 pg/mL (95% CI = 8.86, 11.58; p < 0.00001); adults, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001); children, serum: 0.21 pg/mL (95% CI = 0.05, 0.37; p = 0.01); children, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001). Conclusions: Compared to healthy and age-matched controls, adult individuals with OSAS had significantly higher serum/plasma TNF-α levels. For children with OSAS, significantly higher levels were observed for TNF-α in serum but not in plasma.

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Adropin and Inflammation Biomarker Levels in Male Patients With Obstructive Sleep Apnea: A Link With Glucose Metabolism and Sleep Parameters

Abstract: Plasma adropin concentrations significantly correlate with indices of disease severity in patients with OSA, suggesting that adropin potentially plays an important role in the complex pathophysiology of the disease.

Cited by 41 publications

References 52 publications

Adropin – Potential Link in Cardiovascular Protection for Obese Male Type 2 Diabetes Mellitus Patients Treated with Liraglutide

Adropin – Potential Link in Cardiovascular Protection for Obese Male Type 2 Diabetes Mellitus Patients Treated with Liraglutide

A Review of Adropin as the Medium of Dialogue between Energy Regulation and Immune Regulation

Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

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