Adropin and circadian variation of blood pressure

Bolayır, Hasan Ata; Kıvrak, Tarık; Güneş, Hakan; Bolayir, Aslı; Karaca, Ilgın

doi:10.5603/kp.2018.0006

Cited by 18 publications

(16 citation statements)

References 25 publications

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“…Moreover, Gulen et al, [70] found significantly higher levels of adropin in normotensive patients compared to hypertensive ones with and without target organ damage and they reported that adropin was not correlated with systolic and diastolic blood pressure. However, Bolayır et al, [71] showed decreased adropin levels in nocturnal hypertensive and nondipper hypertensive patients and a strong correlation was found between nighttime blood pressure levels with adropin and hsCRP levels. Animal studies indicated that adropin regulates angiogenesis, increases blood flow and capillary density in an ischemia model [9] .…”

Section: Discussionmentioning

confidence: 92%

Serum Adropin Levels in a Preeclampsia Like L-Name Rat Model Treated with Sildenafil Citrate

Raafat

Fathy²

2018

The Medical Journal of Cairo University

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Background: Preeclampsia, a hypertensive disorder of pregnancy, is detrimental to both mother and fetus. Sildenafil been proposed as a potential therapy to reduce blood pressure and improve uteroplacental perfusion in preeclamptic patients. Adropin is a novel secreted energy homeostasis protein regulating carbohydrate, lipid and protein metabolism, maternal adropin levels in Preeclampsia were still controversy. Aim of the Work: To evaluate serum levels of adropin in preeclampsia-like rat model and in preeclamptic rats treated with Sildenafil and to investigate their associations with some inflammatory, oxidative stress, and metabolic parameters. Material and Methods: 32 pregnant rats were divided randomly into four groups (n=8): Control group, sildenafil treated group, L-NAME group to induce pre-eclampsia and L-NAME with sildenafil treated group. In all groups, maternal Body Mass Index (BMI), placental weights, fetal weights, maternal mean arterial blood pressure (MAP), total urinary proteins, serum glucose, insulin and calculated Homeostatic Model Assessment of Insulin Resistance index (HOMA-IR), serum urea, creatinine, Triglycerides (TGs), Total Cholesterol (TC), Low Density Lipoproteins-cholesterol (LDL-c), High Density Lipoproteins-cholesterol (HDL-c), C Reactive Protein (CRP), Endothelin-1 (ET-1), and adropin were measured, also placental Malondialdehyde (MDA) levels, and activities of the antioxidant enzymes Superoxide Dismutase (SOD) and glutathione peroxidase (GSH) in placental homogenates were determined plus histopathological examination of placental sections were done. Results: L-NAME induced preeclampsia in rats and they showed significant increase in MAP, total urinary proteins, serum levels of glucose, insulin, calculated HOMA-IR, serum urea, creatinine, CRP, ET-1, TGs, TC, LDL-c, adropin and placental tissue MDA with significant reduction in maternal BMI, placental weights, fetal weights, serum HDL-c and placental tissue SOD and GSH activities as compared to other groups, additionally, L-NAME treated and L-NAME + SILD treated groups revealed positive significant correlations between adropin levels and MAP, total urinary proteins, serum levels of urea, creatinine, CRP, ET-1, TGs, TC, LDL-c, and placental tissue MDA, however they showed negative correlations between adropin and BMI, placental weights, fetal

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Section: Discussionmentioning

confidence: 92%

Serum Adropin Levels in a Preeclampsia Like L-Name Rat Model Treated with Sildenafil Citrate

Raafat

Fathy²

2018

The Medical Journal of Cairo University

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“…In a study of 100 hypertensive individuals, reduced adropin levels were observed in the nocturnal hypertensive and nondipper groups. Adropin was associated with a nondipping pattern, suggesting that adropin may be associated with increased target organ damage 51 . Reduced adropin levels were described in patients with hypertensive disorders complicating pregnancy (HDCP) 9,52 …”

Section: Adropin Regulates Biological Pathways That Are Directly or Imentioning

confidence: 99%

“…Adropin was associated with a nondipping pattern, suggesting that adropin may be associated with increased target organ damage. 51 Reduced adropin levels were described in patients with hypertensive disorders complicating pregnancy (HDCP). 9,52 In haemodialysis (HD) patients, reduced serum levels of adropin were associated with dyslipidemia.…”

Section: Adropin Regulates Biological Pathways That Are Directly Ormentioning

confidence: 99%

Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for chronotherapy

2020

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Adropin is a peptide hormone, which plays a role in energy homeostasis and controls glucose and fatty acid metabolism. Its levels correlate with changes in carbohydratelipid metabolism, metabolic diseases, central nervous system function, endothelial function and cardiovascular disease. Both metabolic pathways and adropin are regulated by the circadian clocks. Here, we review the roles of the autonomic nervous system and circadian rhythms in regulating metabolic pathways and energy homeostasis. The beneficial effects of chronotherapy in various systems are discussed. We suggest a potential role for adropin as a mediator of the metabolic system-autonomic nervous system axis. We discuss the possibility of establishing an individualized adropin and circadian rhythm-based platform for implementing chronotherapy, and variability signatures for improving the efficacy of adropin-based therapies are discussed. K E Y W O R D S adropin, autonomic nervous system, chronobiology, metabolic syndrome 1 | INTRODUCTION Metabolic syndrome (MetS) is a cluster of metabolic and cardiovascular complications, which increase the risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D). 1 The pathogenesis of MetS involves multiple factors, including the autonomic nervous system (ANS) and the circadian rhythm. 2 Recently, MetS was also shown to increase the risk and mortality of cancer, 3 with which it shares many risk factors including age, genetic factors, obesity, physical inactivity, unhealthy diet, alcohol, smoking, endocrine disruptors exposure and air pollution. Recent studies have suggested that several peptide hormones play important roles in the modulation of systemic metabolism and energy homeostasis. Adropin is a product of the energy homeostasis associated (Enho) gene and a peptide hormone that plays a role in the regulation of energy homeostasis and controls glucose and fatty acid metabolism. It was originally described as a secreted peptide, with

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“…Alenileşmemiş bir eser, eser sahibinin şahsi alanında olduğundan, haczi de mümkün değildir 62 . Eser sahibinin hakkı, şahsa bağlı bir hak olduğundan üçüncü kişiye devredilemeyen ve haczi de caiz olmayan bir haktır 63 .…”

Section: Gayrimaddi Malvarlığı Unsurlarıunclassified

Ti̇cari̇ İşlemlerde Taşinir Rehni̇ Kanunu Kapsaminda Kurulan Rehi̇nlerde Rehi̇nli̇ Alacaklinin Tatmi̇n Edi̇lmesi̇

Kazanci

2019

İnönü Üniversitesi Hukuk Fakültesi Dergisi

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Özet 6750 sayılı Ticari İşlemlerde Taşınır Rehni Kanunu, rehin hukukumuza olduğu gibi, cebri icra hukukumuza da birçok yenilik getirmiştir. Doktrinde haklı eleştirilerle karşılaşan kanun, bir çok taşınırın rehne konu edilebileceğini düzenlemekte, fakat her bir taşınırların mülkiyetinin ne şekilde devredileceği sorusuna cevap vermemektedir. Borçlunun temerrüdü halinde uygulanacak hükümlerin kanun ile değil de bir yönetmelik ile belirlenmiş olması da, icra ve iflas hukukuna hakim ilkelere aykırılık teşkil etmesi bakımından dikkat çekicidir. Ticari işlemlerde taşınır rehnine sadece dar anlamıyla taşınırların değil, alacak hakkı veya diğer başka hakların da konu edilebilmesi, bu hakların ne şekilde alacaklıya devredileceği konusu, bu süreçte İcra ve İflas Kanunu'nu hükümlerinin de uygulanmasını gerekli kılmaktadır. Rehne konu taşınırın yok olması ya da tür değiştirmesi halinde nasıl bir yol izleneceği de çözümlenmesi gereken bir soru olarak karşımıza çıkmaktadır. Çalışmamızda, öncelikle takip sürecine genel olarak değinilmiş, taşınırın türüne göre alacaklının nasıl tatmin edileceği sorusuna cevap aranmıştır. Bu kapsamda icra ve iflas kanunu hükümlerinin uygulama alanı bulup bulmayacağı da tartışılmıştır.

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Adropin and circadian variation of blood pressure

Cited by 18 publications

References 25 publications

Serum Adropin Levels in a Preeclampsia Like L-Name Rat Model Treated with Sildenafil Citrate

Serum Adropin Levels in a Preeclampsia Like L-Name Rat Model Treated with Sildenafil Citrate

Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for chronotherapy

Ti̇cari̇ İşlemlerde Taşinir Rehni̇ Kanunu Kapsaminda Kurulan Rehi̇nlerde Rehi̇nli̇ Alacaklinin Tatmi̇n Edi̇lmesi̇

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