Adriamycin/cis-platinum/cyclophosphamide combination chemotherapy for advanced carcinoma of the parotid gland

Abstract

Five patients were treated with a combination of Adriamycinlcis-platinumlcyclophosphamide for far-advanced and/or recurrent cancers of the salivary gland. Adriamycin, 40 mglm', and cis-platinum, 50 mg/mf, were given on day 1; cyclophosphamide, 200 m g h ' daily for four days, was given by mouth on the third to sixth day of each monthly therapy course. Two patients achieved a complete remission, each lasting five months, and the three others had partial remissions from one to seven months (median six months) in duration. Therapy was well tolerated. Severe nausea and vomiting occurred on the first day of therapy but was self-limited. There was only mild to moderate leukopenia, no significant thrombo-cytopenia or elevations of serum creatinine, and no evidence of dose-limiting peripheral neuropathy. Adriamycidcis-platinum/cyclophosphamide chemotherapy appears to be effective in the treatment of advanced parotid gland cancers. Cancer 47:645-648.

A randomised phase II trial of epirubicin and 5-fluorouracil versus cisplatinum in the palliation of advanced and recurrent malignant tumour of the salivary glands

“…They also achieved a partial response in three and six patients respectively with a median duration of 6 months in both groups. Other studies (Budd & Groppe, 1983;Vermeer & Pinedo, 1979;Alberts et al, 1981;Tannock & Sutherland, 1980) reported partial responses with median durations of 5 weeks, 5 months, and 12 months.…”

“…Rentschler et al, 1977;Johnson et al, 1964;Alberts et al, 1981;Skibba et al, 1981;Creagan et al, 1983;Richards & Chambers, 1973;Moore et al, 1968). Some of these studies are case reports and some are trials.…”

“…Combination regimens, such as Cylcophosphamide/dox/ Cisplatinum (Alberts et al, 1981;Creagan et al, 1983) and Cyclophosphamide/dox/Vincristine (Skibba et al, 1981) show a very high response rate with a median duration ranging from 1 to 7 months. In the present study there was no response to Epirubicin/5-FU and the median survival was 243 days.…”

“…The most effective drugs are thought to be doxorubicin hydrochloride (dox), Hexamethylmelamine, Cisplatinum, and 5-Fluorouracil (Budd & Groppe, 1983;Vermeer & Pinedo, 1979;Rentschler et al, 1977;Johnson et al, 1964;Alberts et al. 1981;Skibbia et al, 1981;Creagan et al, 1983;Richards & Chambers, 1973;Moore et al, 1968).…”

Management of salivary gland malignancies: current and developing therapies

“…Response rates seem diminished in adenoid cystic carcinoma and when used as second or third line therapy. In the study showing a 100% response rates, only 5 patients were enrolled [46].…”