Adrenomedullin for Risk Stratification of Emergency Patients With Nonspecific Complaints

Abstract

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Adrenomedullin Is Associated With Surgical Trauma and Impaired Renal Function in Vascular Surgery Patients

“…45 In a very recent study, they suggested an algorithm that combined MR-proADM levels with clinical assessment to detect patients who could be discharged from hospital early and with acceptable safety. 14 Nickel and colleagues presented MR-proADM decisive cutoffs between 0.75 nmol/L and 1.5 nmol/L that are comparable to our calculated preoperative MR-proADM cutoff for AKI. We showed that MR-proADM change was a better risk estimator than a single value.…”

“…Among the newly emerging biomarkers, adrenomedullin (ADM) is viewed as one of the candidates that may guide diagnostic and therapeutic decision-making. 13,14 Adrenomedullin belongs to the calcitonin gene-related peptide family and, besides multiple endocrine biological processes, triggers a distinct vasodilation of resistance vessels. 15,16 Adrenomedullin interacts with several complex physiological pathways such as immunomodulation, diuretic, and bactericidal effects.…”

How should nonspecific complaints be defined? Comment to: “nonspecific complaints (NSCs) in the emergency department”

“…The rationale to focus on these patients is the lack of a standardized work-up, the high use of resources, and the risk of adverse outcomes [5][6][7][8]. All publications originating from the prospective multicenter Basel Nonspecific Complaints (BANC) cohorts used the above definition of NSCs [9][10][11][12], but other studies have used varying criteria to define NSCs [13]. There is an inherent difference regarding inclusion criteria between the studies considered by the present systematic review, e.g., some of the included studies were retrospective, and one study [14] has used a post-hoc classification of nonspecific complaints [15].…”

Pro-Adrenomedullin predicts 10-year all-cause mortality in community-dwelling patients: a prospective cohort study

“…Stratification of patients with lower respiratory infection based on a clinical algorithm including ProADM stratification tended to shorten length of hospital stay without an increase in adverse clinical outcome [ 41 , 42 ].…”