Adrenomedullin

Richards, A. Mark; Nicholls, M. Gary; Lewis, Lynley K.; Lainchbury, John G.

doi:10.1042/cs0910003

Cited by 95 publications

(70 citation statements)

References 37 publications

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“…Catecholamines, released by medullary chromaffin cells, and other -adrenoceptor agonists can enhance mineralocorticoid secretion in rodents, bovines and humans (Nussdorfer 1996). Evidence suggests that preproadrenomedullin-derived peptides inhibit catecholamine release by these cells (Richards et al 1996). There is also evidence that ADM stimulates catecholamine release from human adrenal medulla (Andreis et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Effect of adrenomedullin infusion on basal and stimulated aldosterone secretion in conscious sheep with cervical adrenal autotransplants

Salemi

McDougall²,

Hardy³

et al. 2000

Journal of Endocrinology

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In vivo and in vitro studies have shown conflicting effects of adrenomedullin (ADM) on the secretion of steroid hormones from the adrenal gland. While some investigators report no effect of this peptide on the output of various hormones, others have reported both stimulatory and inhibitory roles for ADM. We have shown that basal aldosterone secretion rate (ASR), in conscious sheep with cervical adrenal autotransplants, did not change when ADM was infused directly into the adrenal arterial supply. While not affecting basal ASR, ADM did produce pronounced increases in adrenal blood flow (BF). This elevation of BF in association with ADM infusion was seen in all subsequent experiments. When aldosterone output was acutely stimulated by angiotensin II (AngII), potassium chloride (KCl) and adrenocorticotrophic hormone (ACTH), ADM was seen to drastically reduce the secretion of aldosterone with all agonists studied. After pre-exposure to ADM, all three agonists increased ASR but the magnitude of the responses were somewhat blunted. ADM did not have the same effect on cortisol secretion stimulated by ACTH, suggesting that the ability of this peptide to influence adrenal gland function is limited to the zona glomerulosa. In conditions of chronic elevation of aldosterone levels, such as in Na deficiency, ADM did not display the same inhibitory abilities seen in the acute stimulation experiments. Hence, ADM has been shown to have a direct, inhibitory role on the acute stimulation of aldosterone by AngII, KCl and ACTH while not affecting basal or chronic aldosterone secretion or cortisol secretion stimulated by ACTH.

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Section: Discussionmentioning

confidence: 99%

Effect of adrenomedullin infusion on basal and stimulated aldosterone secretion in conscious sheep with cervical adrenal autotransplants

Salemi

McDougall²,

Hardy³

et al. 2000

Journal of Endocrinology

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“…Several candidate genes hypothesized to influence BP are located in this region, including insulin (at 4 cM from 11pter), calcitonin gene-related peptide (at 21 cM), and adrenomedullin (at 15 cM), a hypotensive peptide with homology to calcitonin gene-related peptide. 26 Previous genome scans have identified evidence of linkage in this region for total and high-density lipoprotein cholesterol, but not for PP or other measures of BP. 27 The chromosome 16q23-24 region demonstrated suggestive univariate linkage evidence for brain atrophy, but no evidence of linkage for PP (Table 2 and Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Genomic Susceptibility Loci for Brain Atrophy in Hypertensive Sibships From the GENOA Study

et al. 2005

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“…Although generally considered a paracrine agent, plasma concentrations of ADM in some conditions (including heart failure) are sufficient to suggest it may play a role in circulatory homeostasis (Richards et al 1996). The ability of ADM to induce a potent and sustained reduction of arterial pressure has been demonstrated in a number of species including sheep (Parkes & May 1995, Charles et al 1997 and humans (Lainchbury et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep

Charles¹,

Nicholls²,

Rademaker³

et al. 2002

Journal of Endocrinology

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The physiological role of adrenomedullin (ADM) in volume and pressure homeostasis remains unclear. Accordingly, we assessed possible modulatory actions of ADM infusions on the neurohumoral response to acute volume loading with dextran in normal conscious sheep. Dextran (15 ml/kg), given with concurrent ADM (5·5 pmol/kg per min -raising plasma ADM from below detection to approximately 10 pmol/l) or vehicle control infusions, induced matched significant (P<0·001 by ANOVA) falls in hematocrit (27-30%) during both ADM and control and similar increases in right atrial pressure (approximately 10 mmHg). Compared with control, both systemic (P=0·033) and pulmonary (P=0·005) arterial pressure and peripheral resistance (P=0·004) were reduced during ADM but were raised post-infusion. The dextran-induced increase in cardiac output was augmented by ADM (P=0·048). Dextran-induced increases in plasma atrial natriuretic peptide (ANP; P=0·008), brain natriuretic peptide (BNP; P=NS) and cyclic guanosine monophosphate (cGMP; P=0·003) were augmented post-ADM infusions. The dextran-induced fall in plasma renin activity (PRA) was attenuated by ADM (P=0·039) whereas plasma aldosterone levels were unaltered. ADM augmented the increase in urinary volume during the second 2-h clearance period post-dextran.Our data indicate that ADM modifies the hemodynamic and hormonal response to an acute volume challenge, enhances natriuretic peptide secretion and reduces systemic vascular resistance. These results provide further evidence that ADM plays a physiological role in volume and pressure homeostasis.

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Adrenomedullin

Cited by 95 publications

References 37 publications

Effect of adrenomedullin infusion on basal and stimulated aldosterone secretion in conscious sheep with cervical adrenal autotransplants

Effect of adrenomedullin infusion on basal and stimulated aldosterone secretion in conscious sheep with cervical adrenal autotransplants

Genomic Susceptibility Loci for Brain Atrophy in Hypertensive Sibships From the GENOA Study

Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep

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