Adrenomedullin Antagonist Infusion Causes Uteroimplantation Growth Restriction

Abstract

The Adrenomedullin peptide hormone has a potent vasorelaxant activity. This novel peptide has shown to be almost a ubiquitous peptide, with the number of tissues and cell types synthesizing adrenomedullin. The pattern of ADM level and gene expression of ADM, its receptor components from early pregnancy has been studied in our present work. In our previous papers we have studied whether antagonism of endogenous adrenomedullin in rats during early gestation period emanated in diminished uterus and implantation growth and found whether this causes through induction of apoptosis.Rats on gestational day 2 were implanted subcutaneously with osmotic (Alzet) minipumps delivering 125 and 250µg rat/ day/ of AM 22-52 and were killed on gestational day 9. This review summarizes a clear cut view of Adrenomedullin receptor and significance of ADM in circulation during gestation period.