Adrenocorticotropin action in isolated adrenal cells. The intermediate role of cyclic AMP in stimulation of corticosterone synthesis.

Sala, G; Hayashi, Keiko; Catt, Kevin J.; Dufau, Maria L.

doi:10.1016/s0021-9258(18)50666-9

Cited by 169 publications

(3 citation statements)

References 14 publications

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“…This data was similar to that obtained consistently with other hormones, including the steroidogenic hormones, human chorionic gonadotrophin (hCG) and luteinizing hormone (LH), in ovary and testis ( 45 – 47 ) and adrenocorticotrophin (ACTH) in adrenal ( 48 ). In the case of testis Leydig cells, for example ( 49 ), the cell-specific response of testosterone to LH increases at hormone concentrations that cause no measurable increase in cAMP, whereas the activation of PKA by LH is very closely linked to the changes in testosterone ( Figure 3 ).…”

Section: Early Events In Camp and Protein Kinase A Activation In Osteoblastssupporting

confidence: 87%

PTH1R Actions on Bone Using the cAMP/Protein Kinase A Pathway

Martın

2022

Front. Endocrinol.

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After the initial signaling action of parathyroid hormone (PTH) on bone was shown to be activation of adenylyl cyclase, its target was found to be cells of the osteoblast lineage, to the exclusion of osteoclasts and their precursors. This led to the view that the osteoblast lineage regulated osteoclast formation, a proposal that was established when the molecular mechanisms of osteoclast formation were discovered. This is in addition to the effect of PTH1Rv signaling throughout the osteoblast differentiation process to favour the formation of bone-forming osteoblasts. Initial signaling in the PTH target cells through cAMP and protein kinase A (PKA) activation is extremely rapid, and marked by an amplification process in which the later event, PKA activation, precedes cAMP accumulation in time and is achieved at lower concentrations. All of this is consistent with the existence of “spare receptors”, as is the case with several other peptide hormones. PTH-related protein (PTHrP), that was discovered as a cancer product, shares structural similarity with PTH in the amino-terminal domain that allows the hormone, PTH, and the autocrine/paracrine agent, PTHrP, to share actions upon a common G protein coupled receptor, PTH1R, through which they activate adenylyl cyclase with equivalent potencies. Studies of ligand-receptor kinetics have revealed that the PTH/PTH1R ligand-receptor complex, after initial binding and adenylyl cyclase activation at the plasma membrane, is translocated to the endosome, where adenylyl cyclase activation persists for a further short period. This behavior of the PTH1R resembles that of a number of hormones and other agonists that undergo such endosomal translocation. It remains to be determined whether and to what extent the cellular effects through the PTH1R might be influenced when endosomal is added to plasma membrane activation.

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Section: Early Events In Camp and Protein Kinase A Activation In Osteoblastssupporting

confidence: 87%

PTH1R Actions on Bone Using the cAMP/Protein Kinase A Pathway

Martın

2022

Front. Endocrinol.

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“…Although the acute and chronic regulation of adrenal function by ACTH (Rae et al, 1979;Wong et al, 1992;Schimmer, 1995) is primarily mediated by PKA-phosphorylated proteins (Podesta et al, 1979;Rae et al, 1979;Sala et al, 1979), ACTH also prompts the activation of members of MAP kinases (Watanabe et al, 1997;Le and Schimmer, 2001). A similar set of protein kinases is also activated in Leydig cells by LH/CG (Dufau et al, 1977;Hirakawa and Ascoli, 2003).…”

Section: Map Kinases and Map Kinase Phosphatases In Acthand Lh-signal...mentioning

confidence: 99%

Tyrosine phosphatases in steroidogenic cells: Regulation and function

Gorostizaga

Maciel

Brion

et al. 2007

Molecular and Cellular Endocrinology

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“…StAR protein is a component of a protein complex that functions in the rate limiting step of steroidogenesis (Stocco, 2000), by transporting cholesterol from the outer to the inner mitochondrial membranes. In all steroidogenic tissues, phosphorylation-dependent events are required for the acute stim-ulation of steroid biosynthesis through the activation of protein kinases (Dufau et al, 1977;Le and Schimmer, 2001;Pezzi et al, 1996;Podesta et al, 1978Podesta et al, , 1979Sala et al, 1979;Schimmer et al, 1977). Among those are the cAMP dependent protein kinase (PKA), the protein kinase C (PKC), the calcium/calmodulin-dependent protein kinase and the mitogen activated protein kinases (MAPKs).…”

Section: Introductionmentioning

confidence: 99%