ADRENOCORTICOTROPIN 52*. Synthesis and Biological Activity of Adrenocorticotropic Peptides with Cystine Bridges

Abstract

Three analogs of the amino terminal nonadecapeptide of adrenocorticotropin which incorporate cystine bridges between positions (5, 10), (3, 10), or (2, 10) have been synthesized. All of the peptide analogs showed reduced biological activity; however, the peptide with the 5, 10 cystine bridge was shown to possess significantly higher lipolytic activity in rat fat cells than the peptides with a 3, 10 or 2, 10 cystine bridge.