Adrenocorticotropic Hormone in Relation to Interrenal Function during Stress in Tilapia (Oreochromis mossambicus)

Balm, P.H.M.; Pepels, P.P.L.M.; Helfrich, S.; Hovens, M.L.M.; Bonga, S.E. Wendelaar

doi:10.1006/gcen.1994.1190

Cited by 129 publications

(111 citation statements)

References 38 publications

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“…The euryhaline teleost Oreochromis mossambicus (tilapia) read ily acclimates to environmental changes, a capacity that is accom panied by an efficient regulation of the production of cortisol, the major corticosteroid in this (3) and other teleost species. We recently described the role of ACTH in the regulation of the cortisol-pro ducing interrenal cells, located in the headkidney (6). In this species also, evidence for additional regulatory factors derived from POMC has been presented (2,16).…”

Section: /^-Endorphin Or-msh Melanotropes Tilapia (Oreochromis Mossammentioning

confidence: 99%

“…Pituitary-interrenal axis Stress VARIOUS peptides derived from the multifunctional precursor protein proopiomelanocortin (POMC) are involved in the adap tation to potentially stressful conditions (6,24). Adrenal corticosteroidogenesis is one of the key targets in this respect.…”

Section: /^-Endorphin Or-msh Melanotropes Tilapia (Oreochromis Mossammentioning

confidence: 99%

“…Adrenal corticosteroidogenesis is one of the key targets in this respect. ACTH secreted by the pars distalis corticotropes has by far been the most studied corticotropic factor in all vertebrate classes (6,18). However, evidence is accumulating that other POMC peptides may be important for tuning corticosteroid production (18).…”

Section: /^-Endorphin Or-msh Melanotropes Tilapia (Oreochromis Mossammentioning

confidence: 99%

“…Neurointermediate lobes and headkidneys were superfused in vitro as described by (4). Homogenates from freshly dissected pituitaries were prepared and sub jected to HPLC as we have reported previously (6). Human acetylated endorphins( 1 -31 ), ( 1 -27), (1-16) (Sigma, St. Louis, MO), and synthetic Xenopus laevis N-acetylated endorphin( 1 -8 ) (31) were used as markers.…”

Section: Animalsmentioning

confidence: 99%

“…N-ac-/?-Endorphin and a-MSH were measured in HPLC frac tions and plasma samples using an RIA system previously em ployed to measure tilapia ACTH (6). The endorphin antiserum is specific for the acetylated ^/-terminal of chum salmon ß-endorphin (29) and has full cross-reactivity with acetylated forms of mammalian /3-endorphin (10).…”

Section: Assaysmentioning

confidence: 99%

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Endorphin and MSH in concert form the corticotropic principle released by tilapia (Oreochromis mossambicus; Teleostei) melanotropes

1995

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diacetyl-tt-MSH. Evidence is presented that the noteworthy corticotropic potency of this HPLC fraction, previously attributed to diacetyl-tt-MSH, results from END and MSH acting in a coordinated fashion. Confinement stress had no effect on plasma N-ac-/?-END immunoreactivity, but led to a decrease in plasma or-MSH levels. Therefore, it seems unlikely that the corticotropic action of the peptides regulates the elevation of cortisol production that takes place during confinement, but it may play a role during other forms of stress that are known to activate the melanotropes.

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Section: /^-Endorphin Or-msh Melanotropes Tilapia (Oreochromis Mossammentioning

confidence: 99%

Section: /^-Endorphin Or-msh Melanotropes Tilapia (Oreochromis Mossammentioning

confidence: 99%

Section: /^-Endorphin Or-msh Melanotropes Tilapia (Oreochromis Mossammentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

Section: Assaysmentioning

confidence: 99%

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Endorphin and MSH in concert form the corticotropic principle released by tilapia (Oreochromis mossambicus; Teleostei) melanotropes

1995

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Immunocytochemical and histological studies on the hypophyseal-gonadal system in the freshwater Nile Tilapia,Oreochromis niloticus (L.), during sexual maturation and spawning in different habitats

Mousa

1999

J. Exp. Zool.

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Distribution and quantification of corticotropin‐releasing hormone (CRH) in the brain of the teleost fish Oreochromis mossambicus (tilapia)

Pepels

Meek

Bonga

et al. 2002

J of Comparative Neurology

107

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The recent characterization of the corticotropin-releasing hormone (CRH) prehormone of the fish tilapia (Oreochromis mossambicus) showed that more variation exists between vertebrate CRH amino acid sequences than recognized before. The present study investigates whether the deviating composition of tilapia CRH coincides with an atypical distribution of CRH in the brain. For this purpose we applied immunohistochemistry, as well as radioimmunoassay (RIA) quantification in brain slices. The results are plotted in a new atlas and reconstruction of the tilapia brain. The largest population of CRH-immunoreactive (ir) neurons is present in the lateral part of the ventral telencephalon (Vl). Approximately tenfold less CRH-ir neurons are observed in the preoptic and tuberal region. The CRH-ir neurons observed in the preoptic region are parvocellular and do not, or hardly, display arginine-vasotocin (AVT) immunoreactivity. CRH-ir neurons are also present in the glomerular layer of the olfactory bulb, in the periventricular layer of the optic tectum, and caudal to the glomerular nucleus. A very dense plexus of CRH-ir terminals is located in the most rostral part of the dorsal telencephalon. This region has not been described in other teleosts and is in the present study subdivided into the anterior part of the dorsal telencephalon (Da) and the anterior part of the laterodorsal telencephalon (Dla). High densities of CRH-ir terminals were observed in and around Vl, in the tuberal region, around the rostral part of the lateral recess, and in the caudal part of the vagal lobe. In the pituitary, CRH-ir terminals are concentrated in the neuro-intermediate lobe. Overall, the immunohistochemical and quantitative data correlated well, as the RIA CRH profile in serial 160-microm slices revealed four peaks, which corresponded with major ir-cell groups and terminal fields. Our results strongly suggest that the CRH-ir cells of Vl project to the rostro-dorsal telencephalon. Consequently, they may not be primarily involved in regulation of pituitary cell types but may subserve other functions. The presence of a CRH-containing Vl-Da/Dla projection seems to be restricted to the most modern group of teleosts, i.e., the Acanthopterygians. Further anatomic indications for non-pituitary-related functions of CRH are found in the vagal lobe and the optic tectum of tilapia. Although the low CRH content of the preoptic region reported here for tilapia may be typical for unstressed fish, the fact remains that remarkably few CRH-ir neurons are involved in regulating the pituitary. Overall, the CRH distribution in the brain of tilapia is more widespread than previously reported for other teleosts.

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Adrenocorticotropic Hormone in Relation to Interrenal Function during Stress in Tilapia (Oreochromis mossambicus)

Abstract: A d r e n o c o r tic o tr o p ic H o r m o n e in R e la tio n to In te rre n a l F u n c tio n d u r in g S t r e s s in T ila p ia ( O r e o c h r o m is m o s s a m b i c u s )

Cited by 129 publications

References 38 publications

Endorphin and MSH in concert form the corticotropic principle released by tilapia (Oreochromis mossambicus; Teleostei) melanotropes

Endorphin and MSH in concert form the corticotropic principle released by tilapia (Oreochromis mossambicus; Teleostei) melanotropes

Immunocytochemical and histological studies on the hypophyseal-gonadal system in the freshwater Nile Tilapia,Oreochromis niloticus (L.), during sexual maturation and spawning in different habitats

Distribution and quantification of corticotropin‐releasing hormone (CRH) in the brain of the teleost fish Oreochromis mossambicus (tilapia)

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