ADRENOCORTICOTROPHIC HORMONE FRAGMENTS MIMIC THE EFFECT OF MORPHINE <i>in vitro</i>

Plomp, G J; Ree, Jan M. van

doi:10.1111/j.1476-5381.1978.tb17293.x

Cited by 40 publications

(4 citation statements)

References 18 publications

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“…22,23 In addition, ACTH-derived fragments were shown to mimic the effects of morphine in vitro. 24 Although the clinical implication of this interaction is unclear, it may confer putative mechanisms for ACTH in PDPH, and in this regard, an ACTH analogue could be more effective than a direct-acting glucocorticoid. This postulation has not been founded, but it would be ideally examined with prospective randomized trials comparing the efficacy of ACTH with that of glucocorticoids in PDPH.…”

Section: Discussionmentioning

confidence: 99%

Cosyntropin for Prophylaxis against Postdural Puncture Headache after Accidental Dural Puncture

Hakim

2010

Anesthesiology

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Section: Discussionmentioning

confidence: 99%

Cosyntropin for Prophylaxis against Postdural Puncture Headache after Accidental Dural Puncture

Hakim

2010

Anesthesiology

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“…Current data suggest that further proteolytic cleavage results in the formation of a-MSH and CLIP from ACTH and P-endorphin, y-LPH and possibly P-MSH from P-LPH (Mains & Eipper 1979). In bioassays, ACTH fragments have morphine-like effects (Plom & Van Ree 1978). ACTH and its fragments affect motivation, learning and behaviour as well as a number of other cerebral functions (De Wied 1976;De Wied & Gispen 1977).…”

Section: Discussionmentioning

confidence: 99%

Interaction of Putative Opioid Peptides with Opiate Receptors

Stengaard‐Pedersen

Larsson

1981

Acta Pharmacologica et Toxicologica

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Binding of 'H-enkephalinamide and 'H-naloxone to Pz-fractions of whole rat brain homogenate displayed saturable, stereospecific binding to receptor sites with at least two binding sites for 'H-metenkephalinamide (type I: KD = 0.4 nM and B, , , = 35 fmol/mg protein; type 11: KD = 5.7 nM and Bmax = 57 fmol/mg protein) and for 'H-naloxone (type I: KD = 1.5 nM and B,,, = 40 fmol/mg protein; type 11: KD = 51 nM and Bma, = 255 fmol/mg protein). P-endorphin and met-and leu-enkephalin produced a concentrationdependent inhibition of 'H-met-enkephalinamide and 'H-naloxone binding with dissociation constants in the nanomolar range, but with very different displacement curves. Purified porcine ACTH (1-39) displaced both 'H-met-enkephalinamide and 'H-naloxone with dissociation constants of 3.4 X 10.' M and 1.8 X

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“…Several mechanisms have been proposed to explain the effects of ACTH or its analogues on headaches. First, it has been shown by several teams that fragments of ACTH interact with opioid receptors in vitro and have morphine-like effects in vivo [42][43][44]. Second, ACTH may increase brain β-endorphins which can change the perception of pain [35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effectiveness and tolerance of tetracosactide in the treatment of post-dural puncture headaches (ESYBRECHE): a study protocol for a randomised controlled trial

Depaulis

Steer

Garessus

et al. 2020

Trials

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Background: Post-dural puncture headache (PDPH) is one of the most common complications of neuraxial anaesthesia. It limits patients' general activity and increases the length of hospital stays and the use of care. It is particularly disabling during the postpartum period, when mothers have to take care of their child. Epidural blood patch is the standard treatment for PDPH. However, it is an invasive procedure that may result in rare but serious complications. Recent evidence has suggested that adrenocorticotropic hormone (ACTH) is effective in the management of PDPH. The aim of this study is to assess the efficacy and safety of tetracosactide (Synacthen®), a synthetic analogue of ACTH, for PDPH treatment in patients who receive neuraxial anaesthesia during labour. Methods: This randomised, double-blind, placebo-controlled, parallel-arm trial, is performed in two French university hospitals. Eligible patients are those suffering from postpartum PDPH, who are randomised to receive either 1 mg of tetracosactide intravenously over 20 min or to 0.9% saline (placebo). The primary endpoint is the rate of epidural blood patch within a 15-day follow-up period. Headache duration, pain intensity, reduction of general activity, increase in length of hospital stay, adverse events, analgesic use (type and duration) and number of blood patches per patient in each group are recorded. Discussion: We expect a decrease in the use of epidural blood patch in those receiving tetracosactide, thus indicating a decrease in PDPH symptoms in these patients. This will define the therapeutic success of tetracosactide and the possibility to use this treatment as a non-invasive alternative to blood patch for PDPH treatment.

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ADRENOCORTICOTROPHIC HORMONE FRAGMENTS MIMIC THE EFFECT OF MORPHINE in vitro

Cited by 40 publications

References 18 publications

Cosyntropin for Prophylaxis against Postdural Puncture Headache after Accidental Dural Puncture

Cosyntropin for Prophylaxis against Postdural Puncture Headache after Accidental Dural Puncture

Interaction of Putative Opioid Peptides with Opiate Receptors

Evaluation of the effectiveness and tolerance of tetracosactide in the treatment of post-dural puncture headaches (ESYBRECHE): a study protocol for a randomised controlled trial

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