Adrenocorticotrophic hormone during the first day of life

Similä, S; Kauppila, Antti; Ylikorkala, O.; Koivisto, Maila; Mäkelä, P.; Haapalahti, J.

doi:10.1007/bf00452108

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…of the ACTH concentrations after logarithmic transformation of the results, which results in lower mean concentrations. However, the declining pattern of ACTH levels after birth is similar to previous observations (14,15). The T levels measured in the cord blood and neonatal circulation agree well with previous results (10,11).…”

Section: Discussionsupporting

confidence: 91%

Pituitary‐adrenal and Testicular Function in Preterm Infants After Prenatal Dexamethasone Treatment

et al. 1982

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Pituitary-adrenal and testicular function was monitored by plasma ACTH and testosterone (T) measurements in preterm newborns (gestational age below 36 weeks), exposed in utero to dexamethasone treatment for prevention of respiratory distress syndrome. A group of age-matched premature newborns and full-term infants served as controls. The cord-blood ACTH level was high in each group (logarithmic means 65-75 ng/l), but decreased within the first 2 days of life to mean levels between 20-30 ng/l on days 3 to 10 inclusive. Dexamethasone treatment had no effect on the postnatal ACTH concentrations when compared with preterm or full-term controls. Similarly, no difference in plasma ACTH were found between untreated preterm and full-term infants during the first 10 days of life. T levels in mixed cord blood were on average 2-3 nmol/l in the preterm male infants. An increase to a mean level of 10 nmol/l was seen in 1 h and 1 d samples. Thereafter, the concentration of T decreased to 2-3 nmol/l on days 3-10 postnatally. No effect of dexamethasone treatment was seen on the postnatal pattern of plasma T. When preterm male and full-term male infants were compared, no difference was seen in the T peak in the first day of life. However, the 1-3, and 60-90 days concentrations of T were 2-fold (p less than 0.01-0.05) higher in the preterm group. It is concluded that prenatal dexamethasone treatment of the mother does not influence the postnatal pituitary-adrenal function as monitored by ACTH measurements. Likewise, no effect of this treatment was observed on the postnatal testicular activity of preterm male infants. The immediate postnatal peak in plasma T levels persisted longer in the preterm than in the full-term male infants.

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Section: Discussionsupporting

confidence: 91%

Pituitary‐adrenal and Testicular Function in Preterm Infants After Prenatal Dexamethasone Treatment

et al. 1982

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“…In the literature there are several reports of elevated ACTH values in human cord plasma (12, 13, 14). The ACTH values show a decreasing course during the first six postnatal hours (14). Thus high AVP values and moderately elevated ACTH levels seem to be a consequence of normal labour.…”

Section: Discussionmentioning

confidence: 93%

Vasopressin, Acth and Neonatal Haemodynamics

Pohjavuori

Fyhrquist

1983

Acta Paediatrica

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Pohjavuori, M. and Fyhrquist, F. (Department of Paediatric Cardiology, Children's Hospital, University of Helsinki, and The Minerva Institute for Medical Research, Helsinki, Finland). Vasopressin, ACTH and neonatal haemodynamics. Acta Paediatr Scand, Suppl. 305: 79–83, 1983.—In 21 normal deliveries, high concentrations of AVP and ACTH in cord blood were associated with higher blood pressure and lower skin temperature, indicating peripheral vasoconstriction. Following Caesarean section after the onset of labour (n=8), cord AVP concentrations and blood pressures were lower than after normal delivery but higher than after elective Caesarean section (n=9). Maternal AVP concentrations at delivery were normal, as were plasma AVP concentrations in all infants 3 days after delivery. The relationship between vasopressin, a potential ACTH releasing factor, and ACTH was interesting. We conclude that the massive release of vasopressin is associated with normal delivery, elevated ACTH values and with peripheral vasoconstriction. These findings reflect favourable adaptation to hypoxia and stress of delivery, intended to redistribute cardiac output to vital organs and may provide for physiological adjustments necessary for extrauterine life.

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“…Rees et al ( I ) studied the reliability criteria and found close similarity to bioactivity . The method has been used by several groups ( 14, IS, 16,17,18,19). To obtain the necessary sensitivity and improve specificity most techniques include a preliminary extraction with Amberlite, Fuller's earth, silicic acid or, as used in the present work, adsorbent glass particles ( 2 ) .…”

Section: Discussionmentioning

confidence: 99%

ACTH IN NORMAL CHILDREN AND CHILDREN WITH PITUITARY AND ADRENAL DISEASES. I: Measurement in Plasma by Radioimmunoassay–Basal Values

Petersen¹

1981

Acta Paediatrica

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Plasma ACTH was measured by radioimmunoassay including preliminary extraction onto adsorbent glass particles. Normal basal values for children 4-16 years of age were 11-82 microgram/ml, corresponding to values found in the literature. Normal values were found in girls with precocious puberty, children with McCune-Albright and Beckwith-Wiedemann's syndrome. Values between 233 and 305 pg/ml were found in untreated children with congenital adrenal hyperplasia. In primary Addison's disease, very high levels (654-1 413 pg/ml) before cortisone therapy and their decline to nearly normal values during therapy are described. ACTH values in a case of pituitary Cushing's syndrome was just above the normal range (104-163 microgram/ml).

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Adrenocorticotrophic hormone during the first day of life

Cited by 10 publications

References 13 publications

Pituitary‐adrenal and Testicular Function in Preterm Infants After Prenatal Dexamethasone Treatment

Pituitary‐adrenal and Testicular Function in Preterm Infants After Prenatal Dexamethasone Treatment

Vasopressin, Acth and Neonatal Haemodynamics

ACTH IN NORMAL CHILDREN AND CHILDREN WITH PITUITARY AND ADRENAL DISEASES. I: Measurement in Plasma by Radioimmunoassay–Basal Values

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