Adrenocorticosteroid therapy in pregnancy

Yackel, Douglass B.; Kempers, Roger D.; McConahey, William M.

doi:10.1016/0002-9378(66)90444-3

Cited by 46 publications

(7 citation statements)

References 11 publications

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“…Neonatal AAI is a potential side effect of the withdrawal of corticosteroids (CS) therapy due to delivery from women exposed during their pregnancy. However, this aetiology has rarely been reported in the literature [10,12]. Here, we report a case of neonatal AAI following the administration of low doses of CS during pregnancy.…”

mentioning

confidence: 76%

Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report

Saulnier¹,

Piguel

Pérault-Pochat

et al. 2009

Eur J Pediatr

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Neonatal acute adrenal insufficiency (AAI) is a rare but severe condition. We report a case of AAI following maternal exposure to moderate doses of corticosteroids during pregnancy. The neonate, born at term, presented with hypoglycaemia complicated by seizures. The AAI was confirmed by endocrine tests and after exclusion of differential diagnoses. Early diagnosis and treatment led to full recovery.

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mentioning

confidence: 76%

Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report

Saulnier¹,

Piguel

Pérault-Pochat

et al. 2009

Eur J Pediatr

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“…Second trimester seems to be the better period to undergo surgery [41]. Postoperative replacement therapy, appropriately increased during labor or caesarean section [39], allowed gestation and delivery to proceed uneventfully [25,27]. In this context it is worth recalling the considerable number of women cured from Cushing's disease by bilateral adrenalectomy, as was the custom in the past [44], in whom pregnancy was carried to term without mishap.…”

Section: Treatment Of Cushing's Disease During Pregnancymentioning

confidence: 97%

“…Cleft palate as well as other congenital malformations do not appear to be more frequent in children born to women with hypercortisolism [14,39].…”

Section: Course Of Pregnancy During Cushing's Diseasementioning

confidence: 99%

Cushing's Disease and Pregnancy

2004

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“…Prednisone therapy with doses greater than 40 mg/day may also increase the rate of spontaneous abortion by 11%, intrauterine fetal death by 27% and perinatal mortality [54]. Neonatal adrenal insufficiency [55,56], neonatal pancytopenia [57], low serum IgA and IgG2 levels for age [58] are rare reported complications of corticosteroid therapy and immunosuppressive medications used during pregnancy. One small study reported that maternal use of oral corticosteroids was independently associated with the occurrence of preeclampsia [46].…”

Section: Management Of Sarcoidosis In Pregnancy and Postpartum Periodmentioning

confidence: 98%

Sarcoidosis in Pregnancy and Postpartum Period

Vahid¹,

Mushlin²,

Weibel³

2007

CRMR

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Sarcoidosis is a multisystemic disease of unknown etiology, characterized by granulomatous inflammation. It typically presents between the ages of 20 to 40 years old. An estimated 0.02% to 0.05% of pregnancies occur in patients with sarcoidosis. Although fetal loss has been reported in mothers with sarcoidosis, limited studies do not suggest an increase risk of fetal or neonatal complications. Several reports suggest an improvement of sarcoidosis during pregnancy. Sarcoidosis, a Th1-mediated disease, seems to follow the same course as rheumatoid arthritis during pregnancy and postpartum. Estrogen levels increase during pregnancy, resulting in a decreased Th1-mediated immune response, which can improve active sarcoidosis. Free plasma cortisol concentrations increase in pregnancy, with plasma levels 2-to 3-fold higher than those of non-pregnant controls, suggesting greater tissue exposure to glucocorticoids during pregnancy. This may result in decreased granulomatous inflammation with improvement in symptoms and clinical findings. During the postpartum period, when free cortisol levels return to the prior non-pregnant levels, reactivation of sarcoidosis can occur. The majority of patients with sarcoidosis will either have a stable disease or will experience improvement in their symptoms. A small group of pregnant mother with active sarcoidosis, however, may develop more progressive disease during pregnancy. The manifestations, course of disease, and treatment options during pregnancy and postpartum period are discussed.

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Adrenocorticosteroid therapy in pregnancy

Cited by 46 publications

References 11 publications

Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report

Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report

Cushing's Disease and Pregnancy

Sarcoidosis in Pregnancy and Postpartum Period

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