Adrenocortical sensitivity, moderated by ongoing stress, predicts drinking intensity in alcohol-dependent men

Adinoff, Bryon; Léonard, David; Price, Julie; Javors, Martin A.; Walker, Robrina; Brown, E. Sherwood; Xiao, Hong; Rao, Uma

doi:10.1016/j.psyneuen.2016.10.011

Cited by 14 publications

(8 citation statements)

References 70 publications

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“…Greater levels of ongo ing life stress strengthened the relationship between ad renocortical sensitivity and posttreatment drinking. En vironmental stressors increased relapse intensity [302].…”

Section: Alcohol Dependencementioning

confidence: 99%

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Allostatic Load and Its Impact on Health: A Systematic Review

Guidi

Lucente

Sonino

et al. 2020

Psychother Psychosom

611

466

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Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events. It involves the interaction of different physiological systems at varying degrees of activity. When environmental challenges exceed the individual ability to cope, then allostatic overload ensues. Allostatic load is identified by the use of biomarkers and clinical criteria. Objective: To summarize the current knowledge on allostatic load and overload and its clinical implications based on a systematic review of the literature. Methods: PubMed, PsycINFO, Web of Science, and the Cochrane Library were searched from inception to December 2019. A manual search of the literature was also performed, and reference lists of the retrieved articles were examined.We considered only studies in which allostatic load or overload were adequately described and assessed in either clinical or non-clinical adult populations. Results: A total of 267 original investigations were included. They encompassed general population studies, as well as clinical studies on consequences of allostatic load/overload on both physical and mental health across a variety of settings. Conclusions: The findings indicate that allostatic load and overload are associated with poorer health outcomes. Assessment of allostatic load provides support to the understanding of psychosocial determinants of health and lifestyle medicine. An integrated approach that includes both biological markers and clinimetric criteria is recommended.

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Section: Alcohol Dependencementioning

confidence: 99%

“…The combined contribution of hypothalamicpitu itaryadrenal reactivity and environmental stressors to relapse severity in alcoholdependent men following treatment was investigated [302]. Greater levels of ongo ing life stress strengthened the relationship between ad renocortical sensitivity and posttreatment drinking.…”

Section: Alcohol Dependencementioning

confidence: 99%

Allostatic Load and Its Impact on Health: A Systematic Review

Guidi

Lucente

Sonino

et al. 2020

Psychother Psychosom

611

466

View full text Add to dashboard Cite

show abstract

“…While drinking to enhance mood is generally not associated with later, problematic drug use, those who consume alcohol in negative social contexts to reduce social anxiety and stress may be more likely to later meet the Diagnostic and Statistical Manual (DSM-V; American Psychiatric Association, 2013 ) criteria for an alcohol use disorder (AUD; Cooper et al, 1992b ; Sinha, 2001 ). And in more extreme cases, exposure to moderate or severe psychosocial stressors can further increase the likelihood of developing a sustained pattern of uncontrollable drinking or the probability of future relapse, particularly in those who drink as a coping mechanism ( Adinoff et al, 2017 ; Brown et al 1990 , 1995 ; Koob and Kreek, 2007 ). This review will evaluate the characteristics of social stressors that may increase the probability of escalated drinking or drug-taking.…”

Section: Clinical Overview: Social Stress As a Risk Factor For Drug Umentioning

confidence: 99%

Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF

Newman

Leonard

Arena

et al. 2018

Neurobiology of Stress

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Both the ostensibly aversive effects of unpredictable episodes of social stress and the intensely rewarding effects of drugs of abuse activate the mesocorticolimbic dopamine systems. Significant neuroadaptations in interacting stress and reward neurocircuitry may underlie the striking connection between stress and substance use disorders. In rodent models, recurring intermittent exposure to social defeat stress appears to produce a distinct profile of neuroadaptations that translates most readily to the repercussions of social stress in humans. In the present review, preclinical rodent models of social defeat stress and subsequent alcohol, cocaine or opioid consumption are discussed with regard to: (1) the temporal pattern of social defeat stress, (2) male and female protocols of social stress-escalated drug consumption, and (3) the neuroplastic effects of social stress, which may contribute to escalated drug-taking. Neuroadaptations in corticotropin-releasing factor (CRF) and CRF modulation of monoamines in the ventral tegmental area and the bed nucleus of the stria terminalis are highlighted as potential mechanisms underlying stress-escalated drug consumption. However, the specific mechanisms that drive CRF-mediated increases in dopamine require additional investigation as do the stress-induced neuroadaptations that may contribute to the development of compulsive patterns of drug-taking.

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“…Following withdrawal, hypoactivation of the HPA axis has been noted in response to provocations with pharmacologic or psychosocial challenges during early abstinence (Adinoff et al, 2005; Blaine and Sinha, 2017). The altered HPA axis response to stress in individuals with alcohol use disorder (AUD) predicts risk for relapse (Junghanns et al, 2003), drinking intensity (Adinoff et al, 2017), and early departure from treatment (Daughters et al, 2009).…”

mentioning

confidence: 99%

Alcohol Use Disorder Masks the Effects of Childhood Adversity, Lifetime Trauma, and Chronic Stress on Hypothalamic–Pituitary–Adrenal Axis Reactivity

Zhang

Price

Léonard³

et al. 2020

Alcoholism Clin & Exp Res

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Background: Individuals with alcohol use disorder (AUD) and those who have experienced traumas or chronic stress exhibit dysregulated hypothalamic-pituitary-adrenal (HPA) axis reactivity. Whether and how trauma and stress histories interact with AUD to affect HPA axis reactivity has not been assessed.Methods: In the present study, 26 healthy male controls and 70 abstinent men with AUD were administered a pharmacologic probe [ovine corticotropin-releasing hormone (oCRH)] and psychosocial stressor to assess HPA axis reactivity. Plasma adrenocorticotropin hormone (ACTH) and cortisol were assessed every 10-20 minutes. Hierarchical clustering of multiple measures of trauma and stress identified 3 distinct clusters: childhood adversity, lifetime trauma, and chronic stress. General linear model procedures were used to examine main effects of group (AUD/control) and interaction effects of the 3 clusters upon net-integrated ACTH and cortisol response.Results: We found that higher levels of childhood adversity, lifetime trauma, and chronic stress were each associated with blunted oCRH-induced ACTH reactivity in controls, but not in the AUD group. Recent chronic stress within the prior 6 months had the strongest influence upon ACTH reactivity in the control group, and lifetime trauma, the least.Conclusions: Childhood adversity, lifetime trauma, and chronic stress likely exert persistent, measurable effects upon HPA axis functioning in healthy controls. This association appears to be masked in individuals with AUD, potentially confounding studies examining the effects of stress, adversity, and/or trauma upon the HPA axis in this population during the protracted withdrawal phase of recovery. Future work targeting stress exposure and reactivity should consider the heightened effect of previous alcohol use relative to past adversity and trauma.

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Adrenocortical sensitivity, moderated by ongoing stress, predicts drinking intensity in alcohol-dependent men

Cited by 14 publications

References 70 publications

Allostatic Load and Its Impact on Health: A Systematic Review

Allostatic Load and Its Impact on Health: A Systematic Review

Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF

Alcohol Use Disorder Masks the Effects of Childhood Adversity, Lifetime Trauma, and Chronic Stress on Hypothalamic–Pituitary–Adrenal Axis Reactivity

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