Adrenocortical Responsivity in Old Age

Hochstaedt, B.; Schneebaum, M.; Shadel, Mordechai

doi:10.1159/000244692

Cited by 11 publications

(2 citation statements)

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“…Schramm et al (6) also reported similar catecholamine responses. Glucose recovery from hypoglycemia appeared to be delayed in the elderly in the data of Hochstaedt et al (3) and those of Schramm et al but was not apparent in the data of Muggeo et al (5) or in the shorter studies of Falk et al (7). More recent studies have examined the glycemic responses to intravenous insulin infusions and determined the glucagon and epinephrine (and cortisol and growth hormone) responses to hypoglycemia (8,9).…”

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confidence: 97%

“…The same reasoning applies to potential roles of other hormones, neurotransmitters, or substrates other than glucose. Earlier studies of the glucose counterregulatory responses to insulin-induced hypoglycemia in the elderly used intravenous insulin injections and focused on cortisol and growth hormone (3)(4)(5)(6)(7). Cortisol responses in the elderly were reported to be similar to (4)(5)(6) or lower than (3) those of young individuals.…”

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Attenuated Glucose Recovery from Hypoglycemia in the Elderly

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Cryer²,

Clutter³

1992

Diabetes

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Advanced age is a risk factor for hypoglycemia caused by sulfonylureas (and insulin) used to treat diabetes mellitus. Therefore, we hypothesized that there is an age-associated impairment of glucose counterregulation and further that this is the result of a sedentary life-style. To test these hypotheses, glycemic and neuroendocrine responses to hypoglycemia, produced by 0.05 U/kg body wt insulin i.v. were measured in nondiabetic elderly subjects (age 65.1 +/- 0.9 yr n = 23)--and in a subset (n = 11) again after 1 yr of physical training (which increased VO2 max by 5.2 +/- 0.9 ml.kg-1.min-1, P less than 0.05)--and compared with these responses in nondiabetic young subjects (23.8 +/- 0.6 yr, n = 18). Recovery from hypoglycemia was attenuated (analysis of variance P less than 0.001) in the elderly (plasma glucose recovery rate 29.4 +/- 2.2 vs. 42.7 +/- 5.0 microM/min, P less than 0.02). This attenuation was the result of a smaller counterregulatory increment in glucose production (maximum increment 13.3 +/- 1.1 vs. 17.2 +/- 1.1 mumol.kg-1.min-1; P less than 0.05) rather than a greater increment in glucose utilization in the elderly. The attenuated glucose recovery was associated with higher plasma insulin concentrations (maximum increment 1385 +/- 122 vs. 940 +/- 72 pM, P less than 0.01) and reduced glucagon responses to hypoglycemia (maximum increment 43 +/- 6 vs. 66 +/- 12 ng/L). The epinephrine, norepinephrine, cortisol, and growth hormone responses were similar, although the epinephrine response was slightly delayed and the growth hormone response appeared smaller in the elderly.(ABSTRACT TRUNCATED AT 250 WORDS)

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Attenuated Glucose Recovery from Hypoglycemia in the Elderly

Marker

Cryer²,

Clutter³

1992

Diabetes

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The Prevention and Correction of Hypoglycemia

Cryer¹

2001

Comprehensive Physiology

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The sections in this article are: Systemic Glucose Balance Postabsorptive State Postprandial State Exercise Other Conditions Physiological Responses to Hypoglycemia Hormonal, Neural and Substrate Responses Symptoms, Cognitive Dysfunction and Signs Glycemic Thresholds Impact of Substrates other than Glucose Physiological Actions of Glucoregulatory Factors Regulatory Factor: Insulin Counterregulatory Factors Integrated Physiology of Glucose Counterregulation Correction of Hypoglycemia Prevention of Hypoglycemia Insight from Pathophysiology Hierarchy of the Redundant Glucose‐Counterregulatory Factors Summary

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Clinical Aspects of Steroid Conjugation

Bongiovanni¹,

Cohn²

1970

Chemical and Biological Aspects of Steroid Conjugation

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Adrenocortical Responsivity in Old Age

Cited by 11 publications

References 0 publications

Attenuated Glucose Recovery from Hypoglycemia in the Elderly

Attenuated Glucose Recovery from Hypoglycemia in the Elderly

The Prevention and Correction of Hypoglycemia

Clinical Aspects of Steroid Conjugation

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